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Periodontal bacteria impedance immunosensor based on conductive polymer

An immunosensor, conductive polymer technology, applied in the direction of material impedance, instruments, scientific instruments, etc., to achieve the effect of increasing fixed quantity and detection specific surface area, easy batch preparation, and improved sensitivity

Inactive Publication Date: 2014-07-02
THE 306TH HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports of biosensors for the direct quantification of periodontal bacteria based on conductive polymers based on the electrical properties of periodontal bacterial cells at home and abroad.

Method used

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  • Periodontal bacteria impedance immunosensor based on conductive polymer
  • Periodontal bacteria impedance immunosensor based on conductive polymer
  • Periodontal bacteria impedance immunosensor based on conductive polymer

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with the accompanying drawings, but the present invention is not limited to the following embodiments.

[0022] The periodontal bacteria impedance immunosensor provided by the present invention includes an interdigital electrode 2 arranged on a silicon oxide substrate 1 and a microfluidic chip channel 3 covalently bonded to the silicon oxide substrate 1, and the microfluidic chip The channel 3 is arranged on the interdigital electrode 2, which is an electrode deposited by a titanium metal layer with a thickness of 10nm and a gold layer with a thickness of 80nm (which can make the electrode more firmly fixed on the silicon oxide substrate 1), which includes 15 pairs of branch electrodes, the interval between the branch electrodes is 50 μm, and the width is 100 μm. The interdigital electrode 2 can be prepared by standard photolithography technology: first, by throwing Glue, pre-baking, exposure and devel...

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Abstract

The invention discloses a periodontal bacteria impedance immunosensor based on a conductive polymer modified electrode. The immunosensor comprises a working microelectrode which is arranged on a solid phase substrate and a microfluidic chip channel which is covalently bonded with the solid phase substrate together, wherein the microfluidic chip channel is formed on the working microelectrode; two ends of the microfluidic chip channel are respectively provided with a sample inlet and a sample outlet; the working microelectrode is connected with an electrochemical workstation through a wire; polypyrrole is deposited on the surface of the working microelectrode; and a specific antibody is modified on the polypyrrole. The periodontal bacteria impedance immunosensor has the advantages that the sample detection is performed in a micro-nano space, a small amount of agents and samples are consumed, and the cost is reduced; and moreover, a conductive polymer film or a nanowire array is modified on the surface of the working microelectrode, the fixed quantity of antibodies in a unit area and the detection specific surface area are increased, so that the sensitivity, interference resistance and response time of the sensor are greatly improved.

Description

technical field [0001] The invention relates to a quantitative detection device for periodontal bacteria, in particular to a periodontal device with conductive polymer modified electrodes, which has high sensitivity, wide detection range, short response time, strong anti-interference, simple process and low cost. Bacterial Impedance Immunosensor. Background technique [0002] Periodontitis is a frequently-occurring and common disease worldwide. It is listed by the World Health Organization as the third largest chronic non-communicable disease that endangers human health. It seriously endangers oral and general health. It is a systemic disease such as cardiovascular disease and diabetes. It is an important risk factor for diseases, and recent studies have found that periodontitis can significantly increase the incidence of certain cancers. At present, the incidence rate of periodontal disease in the adult group in my country is as high as over 80%, and the middle-aged and ol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/569G01N27/327G01N27/02
Inventor 裴振华全保刚牛忠英施生根汤楚华史亮
Owner THE 306TH HOSPITAL OF PLA
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