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Pharmaceutical composition of alanyl glutamine injection and compound amino acid injection

A technology of alanyl glutamine and compound amino acids, which is applied in the field of medicine to achieve the effects of improving clinical application quality and bioavailability, saving costs, and reducing liver damage

Inactive Publication Date: 2013-09-25
灵康药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to overcome the insoluble technical problems existing in the combination of alanyl glutamine and compound amino acids in the prior art, the inventor proposes a new pharmaceutical composition of alanyl glutamine and compound amino acids and its application packaging , and its formula has been improved to achieve the effect of greatly reducing liver damage

Method used

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  • Pharmaceutical composition of alanyl glutamine injection and compound amino acid injection
  • Pharmaceutical composition of alanyl glutamine injection and compound amino acid injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Preparation of Combination Packaged Drugs

[0039] Combination: Alanyl Glutamine Injection 50ml: 10g and Compound Amino Acid Injection 250ml

[0040] making process:

[0041] 1. Preparation of Alanyl Glutamine Injection

[0042] (1) Concentrated formulation: add 15L of water for injection to the concentrated formulation tank, add 10000g of alanyl glutamine, stir to dissolve, add 500g of wet medicinal charcoal, stir for 30 minutes, filter for decarbonization, filter into dilute For the preparation tank, rinse the concentrated preparation tank with water for injection several times, and filter into the thin preparation tank;

[0043] (2) Dilute preparation: Add water for injection to 45L in the dilute preparation tank, adjust the pH value to 5.7 with 0.1mol / L sodium hydroxide solution, add 500g of wet medicinal charcoal, add water for injection to the full amount, and stir 30 minutes;

[0044] (3) intermediate product detection: detect the pH value of filtr...

Embodiment 2

[0054] Example 2 Preparation of Combination Packaged Drugs

[0055] Combination: Alanyl Glutamine Injection 100ml: 20g and Compound Amino Acid Injection 500ml

[0056] making process:

[0057] 1. Preparation of Alanyl Glutamine Injection

[0058] (1) Concentrated formulation: add 30L water for injection to the concentrated formulation tank, add 20000g of alanylglutamine, stir to dissolve, add 1000g of wet medicinal charcoal, stir for 30 minutes, filter for decarbonization, filter into dilute For the preparation tank, rinse the concentrated preparation tank with water for injection several times, and filter into the thin preparation tank;

[0059] (2) Dilute preparation: Add water for injection to 90L in the dilute preparation tank, adjust the pH value to 5.8 with 0.1mol / L sodium hydroxide solution, add 1000g of wet medicinal charcoal, add water for injection to the full amount, and stir 30 minutes;

[0060] (3) intermediate product detection: detect the pH value of filtr...

Embodiment 3

[0070] Example 3 Preparation of Combination Packaged Drugs

[0071] Combination: Alanyl Glutamine Injection 100ml: 20g and Compound Amino Acid Injection 500ml

[0072] making process:

[0073] 1. Preparation of Alanyl Glutamine Injection

[0074] (1) Concentrated formulation: add 30L water for injection to the concentrated formulation tank, add 20000g of alanylglutamine, stir to dissolve, add 1000g of wet medicinal charcoal, stir for 30 minutes, filter for decarbonization, filter into dilute For the preparation tank, rinse the concentrated preparation tank with water for injection several times, and filter into the thin preparation tank;

[0075] (2) Dilute preparation: add water for injection to 90L in the dilute preparation tank, adjust the pH value to 5.9 with 0.1mol / L sodium hydroxide solution, add 1000g of wet medicinal charcoal, add water for injection to the full amount, and stir 30 minutes;

[0076] (3) intermediate product detection: detect the pH value of filtr...

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Abstract

The invention relates to a pharmaceutical composition of an alanyl glutamine injection and a compound amino acid injection, in particular to combination application package. The pharmaceutical composition comprises the alanyl glutamine injection and the compound amino acid injection. When the pharmaceutical composition is in use, the alanyl glutamine injection and the compound amino acid injection are jointly utilized and are intravenously dripped. The combination application package greatly facilitates the requirement of clinical application.

Description

technical field [0001] The invention relates to a pharmaceutical composition of alanyl glutamine injection and compound amino acid injection, in particular to a combination of alanyl glutamine injection and compound amino acid injection which can reduce the side effects of liver function damage The application packaging belongs to the technical field of medicine. Background technique [0002] L-glutamine (L-Glutamine, Gln) is an essential amino acid in the body, and it is also the most abundant amino acid in the human body, and it plays an important role in the synthesis of proteins and nucleic acids. The content of Gln in plasma is as high as 0.8-0.9 mmol / L, accounting for about 20% of the total free amino acids. Gln is the energy source of metabolically active cells such as intestinal mucosal epithelial cells, renal tubular epithelial cells, and immunocompetent cells; it is considered to be the body's nitrogen source carrier, transporting nitrogen sources between tissues ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/05A61K9/08A61K31/4172A61P3/02A61K31/405A61K31/401A61K31/198A61K31/197
Inventor 陈彦陶灵刚
Owner 灵康药业集团股份有限公司
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