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Chinese and western anti-fungal liposome and preparation method thereof

A combination of Chinese and Western, liposome technology, applied in the direction of antifungal agent, liposome delivery, plant/algae/fungus/moss components, etc., can solve the problems of unstable chemical properties, low solubility of voriconazole, etc., to increase the solubility , Improve the stability, the effect of slow release effect is obvious

Active Publication Date: 2012-08-15
ZHUHAI COLLEGE OF JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Voriconazole has extremely low solubility in water, and its chemical properties are unstable in solution state

Method used

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  • Chinese and western anti-fungal liposome and preparation method thereof
  • Chinese and western anti-fungal liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 200g of dried Sophora flavescens and 600g of Rhizoma Polygonatum, add 8000mL of water, extract twice, each time for 2h, and combine the water extracts. Concentrate to 10%~20%, spray dry. Take 10g of spray-dried powder and dissolve it in 100mL of water as a hydration solution for later use. Dissolve 1 g of voriconazole in 50 mL of chloroform. Cholesterol and phospholipids were mixed at a ratio of 1:4 and dissolved in 300 mL of chloroform. Then add the chloroform solution containing voriconazole to the mixture of cholesterol and phospholipids, and mix well. Evaporate the chloroform to dryness with a rotary evaporator to form a thin film, and add hydration solution to hydrate. High-pressure homogenization and freeze-drying to obtain liposome freeze-dried powder.

Embodiment 2

[0021] Take 300g of dried Sophora flavescens and 700g of Rhizoma Polygonatum, add 8000mL of water, extract twice, each time for 2h, and combine the water extracts. Concentrate to 10%~20%, spray dry. Take 10g of spray-dried powder and dissolve it in 200mL of water as a hydration solution for later use. Dissolve 1.5 g of voriconazole in 50 mL of chloroform. Cholesterol and phospholipids were mixed at a ratio of 1:4 and dissolved in 300 mL of chloroform. Then add the chloroform solution containing voriconazole to the mixture of cholesterol and phospholipids, and mix well. Evaporate the chloroform to dryness with a rotary evaporator to form a thin film, and add hydration solution to hydrate. High-pressure homogenization and freeze-drying to obtain liposome freeze-dried powder.

Embodiment 3

[0023] Take 400g of dried Sophora flavescens and 800g of Rhizoma Polygonatum, add 2400mL of water, extract twice, each time for 2h, and combine the water extracts. Concentrate to 10%~20%, spray dry. Take 20g of spray-dried powder and dissolve it in 200mL of water as a hydration solution for later use. Dissolve 2 g of voriconazole in 50 mL of chloroform. Cholesterol and phospholipids were mixed at a ratio of 1:4 and dissolved in 300 mL of chloroform. Then add the chloroform solution containing voriconazole to the mixture of cholesterol and phospholipids, and mix well. Evaporate the chloroform to dryness with a rotary evaporator to form a thin film, and add hydration solution to hydrate. High-pressure homogenization and freeze-drying to obtain liposome freeze-dried powder.

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Abstract

The invention discloses a Chinese and western anti-fungal liposome and a preparation method of the Chinese and western anti-fungal liposome. The Chinese and western anti-fungal liposome mainly consists of radix sophorae flavescentis and rhizoma polygonati extractive, voriconazole powder, hydrogenated soya bean lecithin, cholesterol and the like. The preparation method of the Chinese and western anti-fungal liposome comprises the following steps of: coating the radix sophorae flavescentis and rhizoma polygonati extractive in water phase of liposome, leading the voriconazole to be positioned on a phospholipid film, and combining the Chinese medicinal herb with the western medicine due to the preparation of the liposome. The Chinese and western anti-fungal liposome can play a part in slow release, wherein the Chinese medicinal herb immediately-dissolved medicine voriconazole is exposed after effecting to continuously play the medicine effect, and the slow-release effect is more obvious, and the Chinese medicine rhizoma polygonati has a certain repair function in vivo, so that the effects of treating and repairing can be achieved. The voriconazole is prepared into the liposome, and can be embedded with the phospholipid, so that the dissolubility of the voriconazole can be increased, and the Chinese and western anti-fungal liposome has a certain protection function, therefore, the stability of the voriconazole can be greatly improved, and the Chinese and western anti-fungal liposome plays a certain part in slow release.

Description

technical field [0001] The invention discloses an antifungal Chinese-Western medicine liposome and a preparation method thereof, and relates to the technical field of Chinese-Western medicine. Background technique [0002] Fungi are a type of eukaryotic organisms. The most common fungi are various types of mushrooms, but fungi also include molds and yeasts. Fungal infectious diseases are divided into four categories according to the parts of the fungus that invade the human body: superficial mycosis, skin mycosis, subcutaneous tissue mycosis and systemic mycosis; the former two are collectively called superficial mycosis, and the latter two are also called For deep mycoses. [0003] Voriconazole was approved for marketing by the US FDA in May 2002. It is a second-generation synthetic triazole antifungal drug. It has the advantages of broad antibacterial spectrum and strong antibacterial efficacy. It can treat invasive aspergillus infection and treat fluconazole-resistant d...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/127A61P31/10A61K31/506
Inventor 滕利荣杨东生赵明智吴丽艳金元宝王艳珍王立英张瑶刘明石孟凡欣江连海赵敏
Owner ZHUHAI COLLEGE OF JILIN UNIV
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