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Nanometer composite porous gel microsphere and preparation method thereof

A nanocomposite and microsphere technology, which is applied in the preparation of microspheres, microcapsule preparations, pharmaceutical formulations, etc., can solve the problems of difficult removal and cumbersome process.

Inactive Publication Date: 2012-08-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, like other methods mentioned above, it needs to add a large amount of surfactant or porogen when preparing porous microspheres, which is difficult to completely remove during post-preparation treatment, and the process is cumbersome, which brings many problems to the application.
[0004] The Pickering emulsion polymerization technique without the use of surfactants has been widely used to prepare hybrid core / shell polymer microspheres, while the multiple emulsion polymerization technique based on Pickering emulsions has not been reported.

Method used

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  • Nanometer composite porous gel microsphere and preparation method thereof
  • Nanometer composite porous gel microsphere and preparation method thereof
  • Nanometer composite porous gel microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dissolve 200mg of monomer Am, 20mg of cross-linking agent BIS, and 10mg of initiator V-50 in 2mL of water, and ultrasonically disperse 20mg of clay particles in this solution, add 11mg of sodium chloride to form an aqueous phase solution. Mix 1 mL of toluene and aqueous phase solution to prepare O / W colostrum by ultrasonic emulsification. 2mL colostrum was added to 8mL containing 40mg SiO 2 In the toluene of the particles, the colostrum was re-emulsified by hand shaking to prepare an O / W / O emulsion. Next, the multiple Pickering emulsion prepared by the two-step method was deaerated by Ar gas for 5 minutes, and placed in an ice-water bath with a light intensity of 30mW / cm 2 UV light-induced polymerization. After irradiating for 5 minutes, the distance between the emulsion and the UV lamp is 47cm. The reaction finishes and obtains porous polyacrylamide (PAm) gel microspheres (see figure 1 ).

Embodiment 2

[0026] Dissolve 200mg of monomer NIPAm, 20mg of cross-linking agent BIS, and 10mg of initiator V-50 in 2mL of water, and ultrasonically disperse 20mg of clay particles in this solution, add 11mg of NaCl to form an aqueous phase solution. O / W colostrum was prepared by ultrasonic emulsification by mixing 0.5 mL of toluene and aqueous phase solution. 2mL colostrum was added to 8mL containing 40mg SiO 2 In the toluene of the particles, the colostrum was re-emulsified by hand shaking to prepare an O / W / O emulsion. Next, the multiple Pickering emulsion prepared by the two-step method was passed through Ar gas for 5 minutes to remove oxygen, and then placed in an ice-water bath to initiate polymerization with ultraviolet light with a light intensity of 30 mW / cm2. After irradiating for 5 minutes, the distance between the emulsion and the UV lamp is 47cm. The end of the reaction obtains the multicavity PNIPAm gel microspheres (see Figure 2a ).

Embodiment 3

[0028] Dissolve 200mg of monomer NIPAm, 20mg of cross-linking agent BIS, and 10mg of initiator KPS in 2mL of water, and ultrasonically disperse 20mg of clay particles in the solution, add 11mg of sodium chloride to form an aqueous solution. Mix 0.5 mL of xylene and aqueous phase solution to prepare O / W colostrum by ultrasonic emulsification. 2mL colostrum was added to 8mL containing 40mg SiO 2 In the toluene of the particles, the colostrum was re-emulsified by hand shaking to prepare an O / W / O emulsion. Next, the multiple Pickering emulsion prepared by the two-step method was passed through Ar gas for 5 minutes to remove oxygen, and placed in an oven at 70° C. for 12 hours. The end of the reaction obtains the multicavity PNIPAm gel microspheres (see Figure 2b ).

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Abstract

The invention relates to a nanometer composite porous gel microsphere and a preparation method thereof, which are characterized in that the nanometer composite porous gel microsphere is prepared by the steps of using double Pickering emulsion (O / W / O) as a template, using a water-soluble polymerizable monomer and an initiator as aqueous phase, and adding hydrophilic moderate nanometer particles in the aqueous phase to form oil-in-water type emulsion through emulsification; adding hydrophobic nanometer particles in outer oil phase, adding colostrums into a dispersing agent of the outer oil phase to perform emulsification once again to obtain water-in-oil and oil-in-water type double Pickering emulsion. An aqueous monomer of intermediate phase of the obtained double Pickering emulsion is polymerized to obtain the nanometer composite porous gel microsphere. By means of the preparation method, a large amount of independent gel microspheres with holes insides can be simply prepared. Due to the fact that the functionalization of the nanometer particles can further endow special responsiveness of the microsphere, the nanometer composite porous gel microsphere has wide application prospect in drug encapsulation, targeted slow release, cell culture and other fields.

Description

technical field [0001] The invention relates to the field of functional polymer materials, in particular to a nanocomposite porous gel microsphere and a preparation method thereof. Background technique [0002] Porous polymer microspheres are widely used in chromatographic column fillers, ion exchange resins, bioseparation and catalyst supports and other fields. The preparation methods of porous microspheres are mainly double emulsion method, seed swelling polymerization and SPG membrane emulsification method. Nelissen et al. (Polymer, 1999, 40(13): 3685-3689) prepared porous polystyrene microspheres by suspension polymerization in the presence of a porogen in the monomer phase. Krajnc et al. (React.Funct.Polym., 2005, 65 (1-2): 37-45) on the basis of high internal phase emulsion (that is, the internal water phase volume accounts for more than 74% of the emulsion volume) polymerization technology, using Poly(p-chloromethylstyrene) porous microspheres were prepared by W / O / W...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/56C08F120/54C08F120/06C08F2/24C08J9/00A61K47/32B01J13/14
Inventor 王朝阳邹声文高权星童真
Owner SOUTH CHINA UNIV OF TECH
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