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System and method for carrying out CARS (Coherent anti-Stokes Raman Scattering) imaging by using four-wave mixing signals generated by optical fiber

A four-wave mixing, optical fiber technology, applied in Raman scattering, material excitation analysis, etc., to save costs and simplify the system

Inactive Publication Date: 2012-07-25
INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to overcome the deficiencies of the background technology, the purpose of the present invention is to provide a method and system for eliminating the adverse effects of the FWM signal generated by the optical fiber on the imaging results, which is an inherent problem in the fiber-optic CARS imaging system

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  • System and method for carrying out CARS (Coherent anti-Stokes Raman Scattering) imaging by using four-wave mixing signals generated by optical fiber
  • System and method for carrying out CARS (Coherent anti-Stokes Raman Scattering) imaging by using four-wave mixing signals generated by optical fiber
  • System and method for carrying out CARS (Coherent anti-Stokes Raman Scattering) imaging by using four-wave mixing signals generated by optical fiber

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Embodiment Construction

[0046] Below in conjunction with accompanying drawing and embodiment the present invention will be further described:

[0047] Such as figure 1 As shown, the CARS imaging system proposed by the present invention using the four-wave mixing signal generated by the optical fiber includes: a laser light source 1, a first reflector 2, a second reflector 3, an optical parametric oscillator 4, and a third reflector 5 , the fourth mirror 6, the fifth mirror 7, the sixth mirror 8, the seventh mirror 9, the eighth mirror 10, the precision displacement stage 11, the ninth mirror 12, the first long-wave pass dichroic mirror 13. Tenth mirror 14, coupling objective lens 15, optical fiber 16, two-dimensional scanner 17, focusing lens 18, support sleeve 19, sample 20, second long-wave pass dichroic mirror 21, band-pass filter 22, imaging lens 23. Detector 24 and computer 25.

[0048] Laser light source 1 is with 2~7ps or 10 2 A high-frequency pulse near-infrared laser light source with fs-...

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Abstract

The invention relates to a system and method for carrying out CARS (Coherent anti-Stokes Raman Scattering) imaging by using four-wave mixing signals generated by optical fiber. The system comprises a laser source, multiple reflecting mirrors, an optical parametric oscillator, a precise displacement platform, two long-wave-pass dichroscopes, a coupling objective lens, optical fiber, a two-dimensional scanner, a focusing lens, a supporting sleeve, a sample, a band-pass filter, an imaging lens, a detector and a computer. A light beam which is output after the laser source sends a frequency-doubling light beam for pumping the optical parametric oscillator, and a base-frequency light beam sent by the laser source are respectively pumping light and Stokes light for CARS imaging, and the four-wave mixing signals which are excited after the pumping light and the Stokes light are overlapped on time and space and then transmitted in the optical fiber are probe light for CARS imaging. CARS signal light which is generated after the pumping light and the Stokes light are focused on a sample are not overlapped with the frequency of the pumping light and the frequency of the Stokes light and can be separated by the long-wave-pass dichroscopes. Relative to the standard CARS system, the system disclosed by the invention is not newly provided with any device, has no special requirement on the used devices and is simplified in system and saved in cost.

Description

technical field [0001] The invention relates to medical imaging technology and coherent anti-Stokes Raman scattering imaging technology, in particular to a method and system for coherent anti-Stokes Raman scattering imaging using four-wave mixing signals generated in optical fibers. Background technique [0002] Coherent anti-Stokes Raman scattering (CARS) technology is a new type of non-labeled molecular resonance imaging technology that has been developed rapidly since 1999. It is based on the Raman scattering resonance enhancement mechanism of chemical bonds. Imaging can be performed on specific chemical components in samples without any treatment, including chemical bonds such as C-H, O-P-O, Amide I, H-O (used for detection of liposomes, DNA, proteins, and hydrates respectively), enabling It has chemoselectivity, that is, specificity of imaging. Due to the coherent nature of CARS, its signal intensity is several orders of magnitude higher than that of the usual Raman sc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 杨亚良张雨东李喜琪
Owner INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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