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Dropping pills for preventing and curing hypertension and hyperlipidemia and preparation method

A technology for hyperlipidemia and hypertension, which is applied in the field of dripping pills for preventing and treating hypertension and hyperlipidemia and its preparation field, can solve the problems of low dissolution rate and bioavailability, complicated production process, long dissolution time and the like, and achieves production conditions. Easy control, high bioavailability, simple equipment effect

Inactive Publication Date: 2013-09-11
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a drop pill for the prevention and treatment of hypertension and hyperlipidemia and its preparation method, which can effectively solve the problem of complex production process and inconvenient taking of drugs for hypertension and hyperlipidemia. , Long dissolution time after taking, low dissolution rate and low bioavailability

Method used

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  • Dropping pills for preventing and curing hypertension and hyperlipidemia and preparation method
  • Dropping pills for preventing and curing hypertension and hyperlipidemia and preparation method
  • Dropping pills for preventing and curing hypertension and hyperlipidemia and preparation method

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Effect test

Embodiment 1

[0024]The dropping pills of the present invention are made up of the following weight ratios: 8-25% of the extract of P. 10-20% of the extract and 8-15% of the lotus seed heart extract are made of 100% raw material medicine and mixed matrix. The weight ratio of raw medicine and mixed matrix is ​​1:3-5, and the mixed matrix is ​​heated Melt; add the raw drug into the melted mixed matrix, stir evenly at 80°C, keep warm at 75-80°C for 20-30 minutes to discharge the bubbles, and obtain a molten liquid; adjust the dripper temperature of the dropping pill machine to 75- 80°C, use one of liquid paraffin, soybean oil or simethicone as the condensate, keep the temperature of the condensate at 6-10°C, put the molten liquid in the liquid storage tank of the dropping pill machine at a drop distance of 5-10°C. Drop into the condensate under the conditions of 6cm and 20-60 drops / minute, and condense into pellets with a weight of 35-40mg; take out the formed dropping pills from the outlet of...

Embodiment 2

[0026] The dropping pills of the present invention are made up of the following weight ratios: 10-22% of the chrysanthemum extract, 15-20% of the Ainaxiang extract, 15-22% of the corn silk extract, 15-23% of the hawthorn extract, and 15-23% of the Sophora japonica extract 12-18% of the extract and 10-14% of the lotus seed extract are made of 100% raw material medicine and mixed matrix. The weight ratio of raw medicine and mixed matrix is ​​1:3-5, and the mixed matrix is ​​heated Melt; add the raw drug into the melted mixed matrix, stir evenly at 80°C, keep warm at 75-80°C for 20-30 minutes to discharge the bubbles, and obtain a molten liquid; adjust the dripper temperature of the dropping pill machine to 75- 80°C, use one of liquid paraffin, soybean oil or simethicone as the condensate, keep the temperature of the condensate at 6-10°C, put the molten liquid in the liquid storage tank of the dropping pill machine at a drop distance of 5-10°C. Drop into the condensate under the ...

Embodiment 3

[0028] The dropping pills of the present invention are made of the following weight ratios: 20% of Featherflower extract, 20% of Ainaxiang extract, 20% of corn silk extract, 20% of hawthorn extract, 10% of Huaihua flower extract, and 10% of lotus seed heart extract. The total amount of 10% of the substance is 100% as the raw drug and the mixed matrix, and the weight ratio of the raw drug to the mixed matrix is ​​1:3, wherein the mixed matrix is ​​heated and melted; the raw drug is added to the melted mixed matrix, Stir evenly at 80°C, keep warm at 75-80°C for 20-30 minutes to discharge air bubbles, and obtain a molten liquid; adjust the dripper temperature of the dropping pill machine to 75-80°C, use liquid paraffin as the condensate, and the temperature of the condensate Keep it at 6-10°C, put the molten liquid in the liquid storage tank of the dropping pill machine, drop it into the condensate under the conditions of a drop distance of 5-6 cm and a drop speed of 20-60 drops / m...

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Abstract

The invention relates to dropping pills for preventing and curing hypertension and hyperlipidemia and a preparation method. The dropping pill for preventing and curing hypertension and hyperlipidemia can effectively solves the problems including complicated production process of drug for curing hypertension and hyperlipidemia, inconvenient taking, long in dissolving time after taking and low dissolution rate and bioavailability. The technical scheme is that the dropping pills is prepared by mixing 100% of raw material drugs and mixed matrix, wherein the raw material drugs include, by weight, tridax procumbens extractive 5-25%, blumea balsamifera extractive 10-25%, corn stigma extractive 10-25%, hawthorn extractive 10-25%, sophora flower extractive 5-20% and lotus plumule extractive 5-15%. The weight ratio of the raw material drugs to the mixed matrix is 1:3-5, wherein the raw material drugs are added into molten mixed matrix to be stirred evenly, bubbles are discharged out, mixture is placed into condensate liquid in a droplet mode to be condensed into the pills, the pills are fetched out, and the condensate liquid on the surfaces of the pills is removed. The dropping pills for preventing and curing hypertension and hyperlipidemia is quickly absorbed in a sublingual-taking mode, high in bioavailability, convenient to use and carry, easy to produce and high in production efficiency and is an innovation of the drug for preventing and curing hypertension and hyperlipidemia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a dripping pill for preventing and treating hypertension and hyperlipidemia and a preparation method thereof. Background technique [0002] Hypertension and hyperlipidemia are serious diseases to human health. Hypertension is the most common cardiovascular disease, and it is also the most important public problem in the world. The symptoms of autonomic dysfunction in the early stage of hypertension often affect people's normal work and life, and the damage to important organs such as heart, brain, kidney, etc. Complications can often make the patient lose labor or even life-threatening. According to relevant survey results, the prevalence of hypertension over the age of 18 is 18.8%, and the number of patients in the country is about 160 million. Compared with 1991, there are 70 million new patients, an increase of 31%. According to WHO forecast, in 2020, non-communicable diseas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K9/20A61P9/12A61P3/06
Inventor 李玉贤程方荣褚意新
Owner HENAN UNIV OF CHINESE MEDICINE
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