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Application of D-seromycin in preparing medicine for treating Morphine psychological dependence behavior caused by stress

A cycloserine, stress technology, applied in the field of medicine, to achieve the effect of less side effects on the human body

Inactive Publication Date: 2012-07-18
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies so far have shown that a variety of neural mechanisms mediate the relapse process, such as the theory of learning and memory disorders, the theory of excitatory nervous system hyperactivity, and the theory of Glu imbalance in the brain, etc., which can explain the principle of relapse to a certain extent. One of many factors that cannot be fully equated with relapse factors

Method used

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  • Application of D-seromycin in preparing medicine for treating Morphine psychological dependence behavior caused by stress
  • Application of D-seromycin in preparing medicine for treating Morphine psychological dependence behavior caused by stress
  • Application of D-seromycin in preparing medicine for treating Morphine psychological dependence behavior caused by stress

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Experimental program
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Embodiment Construction

[0014] Experimental data:

[0015] 1. DCS itself induces CPP behavior test

[0016] The results of CPP behavior induced by intraperitoneal injection of DCS (5, 10, 15mg / kg) in mice are shown in figure 1 . In this experiment, it was tested whether DCS was able to induce CPP or CPA. The specific operation is DCS and smooth surface or rough surface box matching training for 4 consecutive days, and the scores between each group are compared. The results show that DCS can not induce CPP behavior training on mice after CPP behavior training on smooth surface (smooth) or rough surface (rough). CPP behavior, there was no significant difference in scores between groups [smooth surface training (F(3,28)=0.230, p=0.875; rough surface training (F(3,28)=0.271, p=0.750). So these data were further It shows that the dose of DCS in this experiment can not induce CPP behavior or CPA behavior, and DCS has no reward or aversive effect. figure 1 Middle: preference scores means score, and Vihi...

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Abstract

The invention relates to an application of D-seromycin in preparing medicine for treating Morphine psychological dependence behavior caused by stress, which belongs to the medicine technical field. A glutamic acid system in brain plays an important role in drug addiction process, and N-methyl-D-aspartic acid (NMDA) receptor which can be combined with glutamic acid to play a physiological effect exists in central nervous system. The NMDA receptor can be functionally inhibited by acting on different recognition sites. At present more side effects are brought by completely inhibiting the NMDA receptor, so antagonist which not only can block the pathological activation of the NMDA receptor but also is free from influencing the physiological activity of the NMDA receptor is important to discover. DCS is a serine natural derivative and is combined with a glycine site in NMDA receptor NR1 subunit to play an effect of excitant, so that internal flow of calcium ions in cells can be increased, but no neurotoxicity is produced. Since the prepared medicine not only can partially excite the NMDA receptor, but also is free from influencing the physiological activity, the medicine has small side effect on the human body.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of D-cycloserine in the preparation of medicines for treating stress-induced morphine-dependent behaviors. Background technique: [0002] D-cycloserine (D-cycloserine), chemical formula C 3 h 6 N 2 o 2 , molecular weight 102.09, fast oral absorption, 3-4 hours blood concentration reaches widely distributed in body tissues and body fluids, drug concentration in cerebrospinal fluid is similar to that in blood; most of it is excreted from urine as prototype, about 35% is excreted metabolism. The minimum inhibitory concentration is 25mg / . [0003] Drug addiction is a long-term, relapsing disorder characterized by uncontrolled use of an addictive drug. The causes of addiction include positive reinforcers (euphoria, reward effects), negative reinforcers (escapism, relief of withdrawal symptoms) and conditioned reinforcers. Negative reinforcement facto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/42A61P25/36
Inventor 牛海晨马原野雷皓
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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