Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of carmustine to prepare drugs for preventing and/or treating psychoactive drug substance dependency and relapse

An active substance, a technology of carmustine, applied in the field of new medical uses of carmustine

Active Publication Date: 2013-10-30
于龙川
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term withdrawal of psychoactive substances can eliminate physical dependence on psychoactive substances to a certain extent, but patients after withdrawal still have a high risk of relapse

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of carmustine to prepare drugs for preventing and/or treating psychoactive drug substance dependency and relapse
  • Application of carmustine to prepare drugs for preventing and/or treating psychoactive drug substance dependency and relapse
  • Application of carmustine to prepare drugs for preventing and/or treating psychoactive drug substance dependency and relapse

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, intravenous injection of carmustine 30mg / kg inhibits the relapse induced by low-dose morphine in rats dependent on morphine

[0022] 1. Materials

[0023] Male SD rats (about 65 days old, Experimental Animal Center, Chinese Academy of Military Medical Sciences) weighing about 270-300 grams.

[0024] Drugs: Morphine Hydrochloride Injection (produced by Shenyang No. 1 Pharmaceutical Factory, stock solution concentration is 10 mg / ml, diluted to 1 mg / ml with sterile normal saline when used), carmustine injection (produced by Tianjin Jinyao Amino Acid Co., Ltd., Dilute to 12.5mg / ml with sterile saline when used).

[0025] The self-medication experimental device used in this experiment was purchased from Anlai Software Technology Co., Ltd., with a size of 29cm×29cm×26cm. It is composed of two parts: the box and the control software. The side wall is made of stainless steel plate, and the bottom plate is made of stainless steel fence. The entire box is placed ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a medicinal application of carmustine, namely application of carmustine in preparation of products for preventing and / or treating psychoactive substance dependence and relapse. A pharmacodynamic test result indicates that after 30mg / kg carmustine is injected through vein, the self-administration relapse of a morphine-induced rat can be effectively inhibited, and the spontaneous activity level of the rat is not influenced, so as to prove that the carmustin has application value in clinical prevention and treatment of psychoactive substance dependence.

Description

technical field [0001] The invention relates to a new medical application of carmustine. Background technique [0002] Dependence on various psychoactive substances is a kind of widespread mental illness. Symptoms of substance dependence are the inability to restrain and excessively seek to take psychoactive substances (including opioids, cocaine, amphetamines, and marijuana). Long-term withdrawal of psychoactive substances can eliminate physical dependence on psychoactive substances to a certain extent, but patients after withdrawal still have a high risk of relapse. At present, there are naltrexone subcutaneous implants, tetrahydroxypalmatine products and compound Chinese herbal medicine preparations that have been patented in China to suppress relapse after drug dependence. [0003] The drug carmustine, also known as Carmusitne, chloroethylnitrosourea, carmustine, BCNU, the English name of the commodity is Carmusitne, and the active ingredient is a small molecule compo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/17A61P25/30A61P25/36
Inventor 于龙川孔庆瑶
Owner 于龙川
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com