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Compositions comprising tramadol and celecoxib in the treatment of pain

A technology of celecoxib and its composition, which is applied in the field of treating severe to moderate pain, can solve problems such as the undetermined correlation of ulcer healing, and achieve good blood-brain barrier penetration and pain treatment effects

Inactive Publication Date: 2012-07-11
LAB DEL DR ESTEVE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

COX-2 has been identified in human gastric periulcer tissue, but its relevance to ulcer healing has not been established

Method used

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  • Compositions comprising tramadol and celecoxib in the treatment of pain
  • Compositions comprising tramadol and celecoxib in the treatment of pain
  • Compositions comprising tramadol and celecoxib in the treatment of pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Preparation of composition doses of tramadol hydrochloride and celecoxib

[0070] Preparation of racemic tramadol hydrochloride and celecoxib at different molar ratios (1:1, 1:3 and 3:1) of (racemic)-tramadol·HCl:celecoxib combination. All drugs and combinations were dissolved in distilled water containing 0.5% hydroxypropylmethylcellulose and administered at 10 ml / kg per rat via intraperitoneal (i.p.) route. Table 1 lists the different ratios prepared at various concentrations.

[0071] Table 1. Corresponding doses of each drug or combination administered intraperitoneally

[0072]

[0073] Effects of thermal hyperalgesia in a postoperative pain model in rats

[0074] The aim of this study was to evaluate the elimination of the combination comprising tramadol / celecoxib, in particular at different molar ratios (1:1, 1:3 and 3:1), in a model of postoperative pain following paw incision in rats. Analgesic efficacy and potency of a combination of tramadol hydrochlor...

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PUM

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Abstract

The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.

Description

technical field [0001] The present invention relates to a pharmaceutical composition comprising tramadol and celecoxib, and its use as a medicament or an analgesic, more particularly for the treatment of severe to moderate pain. Background technique [0002] Pain is a complex response that is functionally classified into sensory, autonomic, motor, and affective components. The sensory aspect includes information about the location and intensity of stimuli, while the adaptive component can be viewed as the activation of endogenous pain modulation and motor planning in response to escape. The affective component appears to include the assessment of pain as unpleasant and stimuli-threat as well as negative emotions triggered by memory and the painful stimulus environment. [0003] In general, pain conditions can be divided into chronic and acute. Chronic pain includes neuropathic pain as well as chronic inflammatory pain, such as arthritis, or unexplained pain, such as fibrom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/135A61K31/415A61K45/06A61P29/00
CPCA61K31/137A61K31/635A61K31/135A61K45/06A61K31/415A61K2300/00A61P19/02A61P19/08A61P21/00A61P25/00A61P25/02A61P25/04A61P29/00A61K31/05A61K31/015A61K31/085
Inventor 恩里克·波蒂略萨利多塞巴斯蒂亚·维德拉塞斯
Owner LAB DEL DR ESTEVE SA
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