Cyclic ketone derivatives and applications thereof as developers and aggregation inhibitors of amyloid protein sediments and neurofibrillary tangles
A technology of derivatives and cyclic ketones, which is applied in the field of preparation of labeled compounds, can solve the problems of large trauma, risk and slow clearance of biopsy
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Embodiment 1
[0321] Embodiment 1, the synthetic method of symmetrical cyclic ketone derivatives:
[0322]
[0323] Synthesis method of symmetrical cyclic ketone derivatives: Under the catalysis of sodium hydroxide solution, carry out Aldol condensation dehydration of cyclopentanone or cyclohexanone and corresponding benzaldehyde to obtain the target compound.
Embodiment 2
[0324] Embodiment 2, the synthetic method of asymmetric cyclic ketone derivatives:
[0325]
[0326] The synthesis method of asymmetric cyclic ketone derivatives: firstly, react with different substituted benzaldehydes and excess cyclopentanone or cyclohexanone to obtain a single chalcone-based reaction product, after separation and purification, react with the corresponding benzene Formaldehyde reacts to obtain the target substance.
Embodiment 3
[0327] Embodiment three, cyclic ketone derivatives 11 C radioactive isotope labeling method:
[0328]
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