Medical slow release material and preparation method thereof
A slow-release material and technology of slow-release microspheres, applied in medical science, surgery, etc., can solve problems such as inability to provide efficient and safe slow-release systems, restrict product market expansion and application, and low bioavailability, and achieve good results. Biocompatibility, good plasticity, high safety effect
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preparation example Construction
[0030] The preparation method of the temperature-sensitive microsphere-loaded injectable medical slow-release material of the present invention mainly includes the following steps:
[0031] 1) Preparation of pulsed sustained-release microspheres: first prepare microspheres loaded with drugs or factors with different release periods, and then mix microspheres with different release periods in a certain proportion to form the same or different "Pulse sustained-release microspheres" for alternate release of drugs;
[0032] 2) Preparation of temperature-sensitive polymer solution: at room temperature, dissolve the temperature-sensitive polymer with physiological saline or phosphate buffer until completely dissolved;
[0033] 3) Mixing: Mix the "pulse slow-release microspheres" prepared in step 1 with the solution prepared in step 2, stir evenly, and prepare a mixed solution of microspheres and polymers.
[0034] The preparation method may further include step 4: curing, specifica...
Embodiment 1
[0043] The method for preparing and using the injectable slow-release material loaded with thermosensitive microspheres specifically comprises the following steps:
[0044] 1) Five types of microspheres with release periods of 1 week, 2 weeks, 4 weeks, 8 weeks and 12 weeks were prepared, and then mixed together in a ratio of 1:1:1:1:1 to form an alternate release " Pulse-type slow-release microspheres", the drug contained in the microspheres with a release period of 1 week and 2 weeks is gentamicin, accounting for 3% of the total mass of the microspheres, which can play an antibacterial and anti-inflammatory role at the wound site; release The drug factor rhBMP-2 contained in three kinds of microspheres with cycle of 4 weeks, 8 weeks and 12 weeks accounted for 0.005% of the total mass of microspheres.
[0045] 2) Dissolve PNIPAAm-g-Ch in phosphate buffer at room temperature until it is completely dissolved to prepare a 5% PNIPAAm-g-Ch solution;
[0046] 3) Mix the "pulse slow...
Embodiment 2
[0050] The method for preparing and using the injectable slow-release material loaded with thermosensitive microspheres specifically comprises the following steps:
[0051] 1) Five types of microspheres with release periods of 1 week, 2 weeks, 4 weeks, 8 weeks and 12 weeks were prepared, and then mixed together in a ratio of 2:1:1:1:1 to form alternate release " Pulse-type slow-release microspheres”, the drugs contained in the microspheres with a release period of 1 week and 2 weeks are vancomycin and gentamicin, respectively accounting for 3% of the total mass of the microspheres, which can treat severe infection in bone defects The site plays the role of antibacterial and anti-inflammatory; the drug factor rhBMP-2 contained in three kinds of microspheres with the release period of 4 weeks, 8 weeks and 12 weeks accounts for 0.008% of the total mass of the microspheres.
[0052] 2) Dissolve PNIPAAm-g-HA in phosphate buffer solution at room temperature until it is completely di...
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