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Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage

A compound antibacterial and chitosan technology, applied in the field of medical materials, can solve the problems of weak antibacterial ability, achieve good sterilization effect, increase strength, and improve physical and chemical properties

Active Publication Date: 2014-04-09
青岛高新区尚达医药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the carboxymethyl group with strong water absorption performance is introduced into the chitosan fiber, which increases its hygroscopicity and chelating ability to metal ions, but it has the problem of weak antibacterial ability.

Method used

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  • Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage
  • Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage
  • Nano silver chitosan composite antibacterial composition, adhesive bandage and preparation method of adhesive bandage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) 2.0g chitosan is dissolved in the 0.35mol / L acetic acid solution of 1000ml;

[0040] 2) Soak 0.02g of dry nano-silver powder in absolute ethanol solution for 10 minutes, ultrasonically oscillate for 30 minutes to obtain dispersed nano-silver sol, mix it with the chitosan acetic acid solution obtained in step 1), and ultrasonically disperse until the solution is clear and transparent After defoaming, adjust the acidity (pH=5.0), and evenly disperse the nano-silver in the chitosan glue;

[0041] 3) Add zinc acetate 0.5g, urea 0.5g and glycerol 2.5g to the nano-silver-chitosan glue obtained in step 2) under slow stirring to improve its physical and chemical properties; obtain nano-silver-chitosan composite antibacterial composition glue liquid;

[0042] 4) Extrude the nano-silver-chitosan composite antibacterial composition glue through the spinneret, and enter the prepared 0.5mol / L sodium hydroxide solution to solidify;

[0043] 5) The fiber tow formed after solidifi...

Embodiment 2

[0045] 1) 50g chitosan is dissolved in the 0.40mol / L acetic acid solution of 1000ml;

[0046] 2) Soak 1g of dried nano-silver powder in absolute ethanol solution for 10 minutes, and ultrasonically vibrate for 30 minutes to obtain dispersed nano-silver sol, mix it with the chitosan acetic acid solution in step 1), and ultrasonically disperse until the solution is clear and transparent. bubble, adjust the acidity (pH=5.0), and evenly disperse the nano-silver in the chitosan glue;

[0047] 3) Add zinc acetate 1g, urea 0.5g and glycerol 2.5g to the nano-silver-chitosan glue obtained in step 2) under slow stirring to improve its physical and chemical properties; obtain nano-silver-chitosan composite antibacterial composition glue ;

[0048] 4) Extrude the nano-silver-chitosan composite antibacterial composition glue through the spinneret, and enter the prepared 0.6mol / L sodium hydroxide solution to solidify;

[0049] 5) The fiber tow formed after solidification is stretched, woun...

Embodiment 3

[0051] 1) 50g chitosan is dissolved in the 0.50mol / L acetic acid solution of 1000ml;

[0052] 2) Soak 1.5g of dry nano-silver powder in absolute ethanol solution for 5min, and ultrasonically oscillate for 40min to obtain dispersed nano-silver sol, mix it with the chitosan acetic acid solution in step 1), and ultrasonically disperse until the solution is clear and transparent Degassing, adjusting the acidity (pH=5.0), uniformly dispersing the nano-silver in the chitosan glue;

[0053]3) Add zinc acetate 2g, urea 1g and glycerin 2.5g to the nano-silver-chitosan glue obtained in step 2) under slow stirring to improve its physical and chemical properties; obtain nano-silver-chitosan composite antibacterial composition glue;

[0054] 4) Extrude the nano-silver-chitosan composite antibacterial composition glue through the spinneret, and enter the prepared 0.65mol / L sodium hydroxide solution to solidify;

[0055] 5) The fiber tow formed after solidification is stretched, wound and s...

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Abstract

The invention relates to a nano silver chitosan composite antibacterial composition which comprises nano silver, chitosan and an additive, wherein the mass of the nano silver is 1 to 5 percent of that of the chitosan; and the mass of the additive is 7 to 20 percent of that of the chitosan. The invention further relates to an adhesive bandage comprising the nano silver chitosan composite antibacterial composition and a preparation method thereof. According to the composite antibacterial adhesive bandage prepared by the method, the chitosan and silver elementary substances are firmly combined and the elementary substances are uniformly distributed and are difficult to lose. The antibacterial composition and the adhesive bandage comprising the antibacterial composition can be antibacterial, antalgic and anthemorrhagic and can be used for preventing adhesion, repairing the wound surface of a wound and inhibiting scars from forming.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a nano-silver chitosan composite antibacterial composition, a wound plaster containing the composition and a preparation method of the wound plaster. Background technique [0002] Chinese invention patent application (publication number CN101721733A) discloses a kind of medical chitosan antibacterial dressing, and it is to take chitosan fiber as raw material, and the chitosan fiber is spray-coated with silver-loaded nano-titanium dioxide particles to make a dressing product. The spraying process is as follows: chitosan fiber spinning-cutting into short fibers-spraying silver-loaded nano-titanium dioxide on chitosan short fibers-making chitosan products. [0003] The chitosan antibacterial dressing prepared by this process only adheres nanomaterials on the surface of the dressing and the adhesion is uneven, easy to fall off, and its function is not easy to fully exert....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44
Inventor 李育强孙士学但丽霞
Owner 青岛高新区尚达医药研究所
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