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Method for extracting sinigrin of Thlaspi arvense and medical application of sinigrin of Thlaspi arvense

A technology of glucosinolates and hibiscus, which is applied in the directions of medical preparations, pharmaceutical formulations, and drug combinations containing active ingredients, and achieves the effects of clear medicinal ingredients, simple preparation process and wide sources.

Inactive Publication Date: 2012-07-11
SICHUAN DIHON MEDICAL DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is used for conjunctival congestion and swelling pain, wrist and abdominal distension pain, hypochondriac pain, intestinal abscess, edema, leukorrhea, sore furuncle and carbuncle. There is no report on the treatment of gout at present

Method used

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  • Method for extracting sinigrin of Thlaspi arvense and medical application of sinigrin of Thlaspi arvense
  • Method for extracting sinigrin of Thlaspi arvense and medical application of sinigrin of Thlaspi arvense
  • Method for extracting sinigrin of Thlaspi arvense and medical application of sinigrin of Thlaspi arvense

Examples

Experimental program
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Effect test

Embodiment 1

[0010] Example 1 Traditional extraction method

[0011] Take 10kg of Thlaspi and crush it to 10-100 mesh, add 50L of water, and extract three times at 60-75℃ for 5-8 hours each time. Combine the three water extracts, concentrate them into an extract, and dry to obtain 0.8 kg extract is sample A.

Embodiment 2

[0012] Example 2 Water extraction and alcohol precipitation method

[0013] Take 0.5 kg of sample A, add 2.5 L of 85% ethanol to it, after filtering by alcohol precipitation, the ethanol filtrate recovery solvent is concentrated to 1.5 L, the resulting concentrated solution is kept at 4°C for 10 hours, filtered, the precipitate is collected, and dried. Sample B was obtained, total glucosinolates 0.15 kg.

Embodiment 3

[0014] Example 3 Alcohol extraction and alcohol precipitation method

[0015] Take 10 kg of Thlaspi and crush it to 10-100 mesh, add 50L of 75% ethanol, extract three times at 40-55℃, 4-6 hours each time, concentrate the alcohol extract into an extract, add 4L times the amount 85% ethanol, placed in 4°C refrigeration for 15 hours, filtered, collected the precipitate, and dried to obtain sample C with 0.18 kg of glucosinolates.

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Abstract

The invention discloses a Thlaspi arvense extract, in particular to a method for preparing sinigrin of Thlaspi arvense. The method comprises the following steps: using a water-extracting and ethanol or methanol (70-90 percent) precipitating method to extract and obtain Thlaspi arvense extractum; or using a ethanol or methanol (50-90 percent) extracting ethanol or methanol (70-90 percent) precipitating method to extract and obtain the Thlaspi arvense extractum; refrigerating the extract at a temperature ranging from 4 to 10 DEG C for 8-24 hours, and forming precipitations; and filtering and drying the precipitations to obtain the sinigrin of Thlaspi arvense. The invention also discloses application of the Thlaspi arvense extract in preparing a medicine for treating or preventing hyperuricemia. The effect of treating or preventing gout can be generated through the method.

Description

Technical field [0001] The invention relates to the field of medicine. More specifically, it relates to a preparation method and application of Thlaspi extract, especially a preparation method of total glucosinolate of Thlaspi and its application in the preparation of drugs for preventing hyperuricemia and gout. Background technique [0002] Gout is a group of metabolic diseases caused by excessive uric acid and / or decreased excretion of uric acid due to disorder of purine metabolism, and accumulation and precipitation in the body. The clinical manifestations are hyperuricemia, gouty arthritis, joint deformities, kidney disease, uric acid stones, and gout stones. Uric acid is a product of human purine metabolism, and hyperuricemia is the main biochemical basis of gout. Gouty arthritis is when serum uric acid levels increase, urate deposits in joint tissues, irritating joints and triggering a series of inflammatory reactions. The symptoms of gout are mainly redness, swelling, he...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P19/06A61P19/02
Inventor 余红伟马燕如
Owner SICHUAN DIHON MEDICAL DEV
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