Chromatographic analysis system and chromatographic analysis method

A chromatographic analysis and chromatographic column technology, applied in analytical materials, material separation, measurement devices, etc., can solve problems such as inability to separate substances, decrease in instrument sensitivity, and broadening of chromatographic peaks, so as to avoid sensitivity decline and improve sensitivity. , the effect of improving the signal-to-noise ratio

Active Publication Date: 2012-07-04
HANGZHOU PUYU TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional inlets have larger volumes, see figure 1
Therefore, the sample needs to be split in the inlet and then enter the chromatographic column for analysis; at the same time, for the inlet with a large internal volume, there is a large dead volume between the inlet of the inlet and the vaporization chamber, which will lead to broadening of the chromatographic peaks Seriously, the substances cannot be separated better; if you want to get a better separation effect, you must set the split ratio to a larger value, but a larger split ratio will lead to a decrease in the sensitivity of the instrument

Method used

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  • Chromatographic analysis system and chromatographic analysis method
  • Chromatographic analysis system and chromatographic analysis method
  • Chromatographic analysis system and chromatographic analysis method

Examples

Experimental program
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Effect test

Embodiment 1

[0056] A chromatographic analysis system, comprising a sampling unit, a sampling port, a control unit, a chromatographic column and a detector;

[0057] 1. The sampling unit includes an adsorption thermal desorption sampling module and / or a direct sampling module of an injection port; the adsorption thermal desorption sampling module includes an adsorption tube and its accessories and a flow path switching module; the injection port Direct injection modules are microsyringe and / or solid-phase microextraction injectors, each including a needle that can be inserted into an injection port.

[0058] The adsorption thermal desorption sampling module and the direct sampling module of the injection port are existing technologies in the field, and will not be repeated here.

[0059] 2. A sample channel is set in the sample inlet, and the mobile phase carries the sample injected into the sample port to flow along the sample channel; when the mobile phase passes through the sample chann...

Embodiment 2

[0081] A chromatographic analysis system, different from the chromatographic analysis system described in embodiment 1 is:

[0082] 1. The chromatographic analysis system of this embodiment also includes a flow path switching unit; the flow path switching unit is respectively connected to the sample inlet, the sample injection unit and the control unit;

[0083] 2. The sampling unit of this embodiment includes at least two sampling modules, which are at least two adsorption thermal desorption sampling modules, or at least two direct sampling modules with injection ports, or at least one adsorption thermal desorption sampling module and A combination of at least one inlet direct injection module;

[0084] The control unit controls the flow path switching unit to selectively connect any one of the at least two sampling modules with the sampling port.

[0085] The present embodiment also provides a chromatographic analysis method, which is different from the chromatographic anal...

Embodiment 3

[0089] see figure 1 , a chromatographic analysis system comprising a sampling unit, a sampling port 11, a control unit 3, a chromatographic column 4 and a detector 5.

[0090] 1. Sample injection unit

[0091] The sampling unit includes an adsorption thermolysis sampling module 101; the adsorption thermolysis sampling module 101 includes an adsorption tube 1011 and its accessories and a flow path switching module.

[0092] 1.1. Adsorption thermal desorption sampling module 101

[0093] The adsorption thermolysis sampling module 101 includes an adsorption tube 1011 and its accessories and a flow path switching module connected to the control unit 3;

[0094] The adsorption tube 1011 is used to adsorb substances in the sample; the accessories of the adsorption tube include a sampling pump 1013, a heating module and a temperature control module, etc.;

[0095] The flow switching module includes a solenoid valve 1012 and a multi-channel selector valve 1014;

[0096] One end of...

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PUM

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Abstract

The invention relates to a chromatographic analysis system which comprises a sample inlet, a sample introduction unit, a control unit, a chromatographic column and a detector and has the characteristic that the control unit is used for controlling the communication between the sample introduction unit and the sample inlet; a sample channel is arranged in the sample inlet; mobile phases carry a sample injected into the sample inlet to flow along the sample channel; and when the mobile phases pass through the sample channel at any moment, the mobile phases positioned on the cross section of the sample channel at the previous moment are all replaced. The invention also provides a chromatographic analysis method. The chromatographic analysis system and the chromatographic analysis method have the advantages of wide application scope, good separation, high sensitivity and the like.

Description

technical field [0001] The invention relates to a chromatographic analysis system and method, in particular to a chromatographic analysis system and method. Background technique [0002] Portable chromatographic analysis systems usually adopt two methods of adsorption thermal desorption sampling and direct injection from the injection port. The adsorption thermal desorption sampling method is suitable for the determination of trace substances in gases. The direct injection method of the injection port includes ordinary micro-syringe injection and solid-phase microextraction (SPME) injector injection. Among them, ordinary micro-syringe sampling is suitable for the analysis of thermally stable gases and liquid samples whose boiling point is generally below 500°C, and SPME sampling is suitable for the analysis of trace organic compounds in gases, liquids, and solids. [0003] At present, since different sampling methods require different sampling equipment and different confi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/24
Inventor 段炼刘立鹏李天麟李晓旭马乔邓嘉辉粱炎邱明俞建成
Owner HANGZHOU PUYU TECH DEV CO LTD
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