Compound medicament for rehabilitation after myocardial infarction and preparation method thereof

A drug and compound technology, which is applied in the field of compound drugs for rehabilitation after myocardial infarction and its preparation, can solve problems such as unfavorable long-term prognosis, reduction of high-density lipoprotein cholesterol, slow heart rate, etc.

Inactive Publication Date: 2012-07-04
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these β-blockers slow down the heart rate and inhibit the conduction of the heart, so the clinical application is limited. Non-selective β-blockers can also increase serum triglycerides and reduce high-density lipoprotein cholesterol. unfavorable for long-term prognosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1, weight ratio of raw materials: 1 part of metoprolol, 200 parts of Erigeron breviscapine, 800 parts of Ophiopogon japonicus, 800 parts of Dawujincao, and 10 parts of peach gum. The preparation method is as follows:

[0017] (1) After soaking Erigeron breviscapitalis in water, extract the volatile oil by steam distillation for 4 hours to obtain the volatile oil, and collect the distilled aqueous solution and drug residue in a separate device for later use;

[0018] (2) Mix the distilled aqueous solution obtained in step 1, drug residues, Ophiopogon japonicus and Ophiopogon japonicus, decoct for 1 hour, filter, and concentrate the filtrate to a thick paste with a relative density of 1.25 at 60°C. At 60°C, add After the peach gum is stirred and mixed, it is dried under reduced pressure to form a dry extract, and then crushed into an extract powder;

[0019] (3) After mixing the extract powder obtained in step 2 and metoprolol powder evenly, spray the volatile oi...

Embodiment 2

[0020] Example 2, the weight ratio of raw materials: 2 parts of atenolol, 150 parts of escutellaria, 700 parts of Radix Ophiopogon japonicus, 700 parts of Dawujincao, and 8 parts of peach gum. The preparation method is as follows:

[0021] (1) After soaking Erigeron breviscapitalis in water, extract the volatile oil by steam distillation for 3 hours to obtain the volatile oil, and collect the distilled aqueous solution and drug residue in a separate device for later use;

[0022] (2) Mix the distilled aqueous solution obtained in step 1, drug residues, Ophiopogon japonicus and Ophiopogon japonicus, decoct for 1 hour, filter, and concentrate the filtrate to a thick paste with a relative density of 1.26 at 60°C. At 60°C, add After the peach gum is stirred and mixed, it is dried under reduced pressure to form a dry extract, and then crushed into an extract powder;

[0023] (3) After mixing the extract powder obtained in step 2 and atenolol powder evenly, spray the volatile oil o...

Embodiment 3

[0024] Example 3, the weight ratio of raw materials: 4 parts of bisoprolol, 100 parts of Erigeron breviscapine, 600 parts of Ophiopogon japonicus, 600 parts of Dawujincao, and 6 parts of peach gum. The preparation method is as follows:

[0025] (1) After soaking Erigeron breviscapitalis in water, extract the volatile oil by steam distillation for 2 to 4 hours to obtain the volatile oil, collect the distilled aqueous solution and drug residue in a separate device for later use;

[0026] (2) Mix the distilled aqueous solution obtained in step 1, drug residues, Ophiopogon japonicus and Ophiopogon japonicus, decoct for 1 hour, filter, and concentrate the filtrate to a thick paste with a relative density of 1.27 at 60°C. At 60°C, add After the peach gum is stirred and mixed, it is dried under reduced pressure to form a dry extract, and then crushed into an extract powder;

[0027] (3) After mixing the extract powder obtained in step 2 and bisoprolol powder evenly, spray the volati...

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PUM

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Abstract

The invention discloses a compound medicament for rehabilitation after myocardial infarction and a preparation method thereof, and the compound medicament can be used for solving the problem of rehabilitation treatment after myocardial infarction. The compound medicament is characterized by being prepared from the following raw materials in parts by weight: 1 to 5 parts of beta receptor blocker, 10 to 200 parts of erigeron breviscapus, 600 to 800 parts of liriope, 600 to 800 parts of asarum forbesii maxim, and 5 to 10 parts of peach gum, wherein the beta receptor blocker is one of metoprolol,atenolol, bisoprolol and carvedilol. The preparation method of the medicament comprises the following steps: extracting erigeron breviscapus volatile oil; performing aqueous extract on residues, liriope and asarum forbesii maxim, concentrating and drying; uniformly mixing the extract powder with the beta receptor blocker; and adding the volatile oil, and tabletting. Clinical application proves that the compound medicament has the characteristics of good curative effect and higher safety in rehabilitation after myocardial infarction, and is worth of clinical application and popularization.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a compound medicine for rehabilitation after myocardial infarction and a preparation method thereof. Background technique [0002] According to incomplete statistics in 2002, there are more than 700,000 cases of myocardial infarction (MI) in my country every year, and the incidence rate is still worthy of attention. During recovery hospitalization after acute ST-segment elevation MI, patients should be treated with risk factor reduction, lipid-lowering therapy, smoking cessation, and other interventions. Beta blockers are a class of drugs that selectively bind to beta adrenergic receptors, thereby antagonizing the agonistic effects of neurotransmitters and catecholamines on beta receptors. Metoprolol, atenolol, bisoprolol, and carvedilol have been widely accepted by evidence-based medicine to improve the prognosis of patients after myocardial infarction and reduce car...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P9/10A61K31/138A61K31/165A61K31/403
Inventor 罗群王功国
Owner 罗群
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