Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A cardiovascular and cerebrovascular disease, compound technology, applied in the field of medicine, can solve the problems that patients cannot bear and limit clinical application

Inactive Publication Date: 2014-08-13
XIAN LIBANG ZHAOXIN BIOTECH CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the side effects produced, especially vascular pain and other adverse reactions, make patients unbearable, thereby limiting the clinical application of alprostadil

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Compound injection preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 compound water injection

[0043] formula:

[0044]

[0045]

[0046] Preparation:

[0047] Take a certain amount of polyethylene glycol and dissolve it in water for injection, the final concentration is 400mg / ml (w / v). Add the prescribed amount of dextran and mix well. Get the alprostadil and edaravone of prescription quantity, be dissolved in above-mentioned solution, until completely dissolving; Add the sodium bisulfite of prescription quantity and stir to dissolve. The obtained solution was filtered with a 0.22 μm microporous membrane, and the filtrate was filled and sealed in ampoules.

Embodiment 2

[0048] The preparation of embodiment 2 compound fat emulsion (high content)

[0049] formula:

[0050]

[0051] Preparation:

[0052] Under the protection of nitrogen, take the prescribed amount of alprostadil and edaravone and put them into the prescribed amount of soybean oil, and stir at 70° C. to fully dissolve into a solution. Then add the prescribed amount of emulsifier and mix. After the dissolution is complete, add the prescribed amount of oleic acid and vitamin E. After mixing evenly, a mixed oil phase A is formed; 60ml of water for injection and the prescribed amount of glycerin are mixed at 70°C to form a water phase B. ;Under the protection of nitrogen, slowly add the water phase B to the oil phase A at 70°C for mixing, disperse at a high speed of 3000r / min, and stir mechanically for 60 minutes to make colostrum. Homogenize for 7 to 8 times under high temperature to obtain a uniform milky solution; filter the above milky solution, seal it with nitrogen gas, st...

Embodiment 3

[0053] The preparation of embodiment 3 compound fat emulsion (in content)

[0054] formula:

[0055]

[0056] Preparation method: with the preparation method of Example 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a compound injection preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The preparation method comprises the following steps of: taking alprostadil and edaravone as active pharmaceutical ingredients, and compounding the alprostadil and the edaravone according to a certain ratio to form a certain injection preparation. With the adoption of the compound injection preparation, heart vessels or brain vessels can be effectively dilated, the chronic arterial occlusive diseases, caused by thromboangiitis obliterans, diabetes and the like, can be effectively treated, and meanwhile, the pain generated in the conventional injection of an alprostadil preparation can be remarkably abated due to the adoption of the compound preparation of the alprostadil and the edaravone.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a compound injection preparation with edaravone and alprostadil as main active pharmaceutical ingredients and a preparation method thereof. The compound preparation can effectively treat cardiovascular and cerebrovascular diseases. Background technique [0002] Alprostadil has another name called prostaglandin E1 (prostaglandin E1, PGE1), and its chemical name is: 11a, 15 (S)-bishydroxyl-9-keto-13-antiprostenic acid, and its chemical structural formula is as follows: [0003] [0004] Alprostadil is an endogenous physiologically active substance with various physiological and pharmacological effects. It can expand blood vessels, inhibit platelet aggregation, thromboxane A2 generation, atherosclerotic lipid plaque formation and immune complexes, and can expand peripheral and coronary vessels, reduce gastric juice secretion, and stimulate small intestine and uterine peristalsis. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5575A61K31/4152A61P9/00A61K9/107A61K9/10A61K9/08A61K9/19
Inventor 王汝涛陈涛胡惠静王惟娇张阳
Owner XIAN LIBANG ZHAOXIN BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com