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Eye ointment for treating fungal keratitis

A technology for fungal keratitis and ophthalmic ointment, which is applied in the direction of antifungal agent, ointment delivery, drug combination, etc., can solve the problems of fast metabolism, limited antibacterial effect of eye fungi, and long-lasting drug effect, and achieves simple preparation method, Relieves eye pain symptoms and has a long-lasting effect

Inactive Publication Date: 2012-07-04
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Study shows drug has limited antimicrobial effect on eye fungus, less effective treatment
[0004] According to clinical observations, eye drops stay in the eyes for a short time, metabolize quickly, and cannot maintain the local drug treatment concentration in the eyes well, while eye ointments stay in the eyes for a long time, and the drug effect is long-lasting
In addition, existing antifungal eye drops have no therapeutic effect on iridociliary body inflammation secondary to fungal keratitis

Method used

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  • Eye ointment for treating fungal keratitis
  • Eye ointment for treating fungal keratitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, the preparation of treating fungal keratitis eye ointment

[0033] In a 100,000-level purification workshop, medical yellow vaseline, liquid paraffin, and lanolin are mixed in a ratio of 8:1:1 to make an eye ointment base. Take 3 kg of matrix and add atropine sulfate ((C 17 h 23 NO 3 )·H 2 SO 4 ·H 2 (2) 30 grams, then add terbinafine hydrochloride (by C 21 h 25 N meter) 125 grams. Fully mix to obtain terbinafine hydrochloride atropine ophthalmic ointment, which is aseptically divided into about 3 grams per box.

Embodiment 2

[0034] Embodiment 2, the preparation of treating fungal keratitis eye ointment

[0035] In a 100,000-level purification workshop, medical yellow vaseline, liquid paraffin, and lanolin are mixed in a ratio of 8:1:1 to make an eye ointment base. Get 3.2 kg of matrix and add atropine sulfate ((C 17 h 23 NO 3 )·H 2 SO 4 ·H 2 (2) 20 grams, then add terbinafine hydrochloride (by C 21 h 25 N meter) 100 grams. Fully mix to obtain terbinafine hydrochloride atropine ophthalmic ointment, which is aseptically divided into about 3 grams per box.

Embodiment 3

[0036] Embodiment 3, the preparation of treating fungal keratitis eye ointment

[0037] In a 100,000-level purification workshop, medical yellow vaseline, liquid paraffin, and lanolin are mixed in a ratio of 8:1:1 to make an eye ointment base. Get 2.8 kg of matrix and add atropine sulfate ((C 17 h 23 NO 3 )·H 2 SO 4 ·H 2 (2) 40 grams, then add terbinafine hydrochloride (by C 21 h 25 N meter) 150 grams. Fully mix to obtain terbinafine hydrochloride atropine ophthalmic ointment, which is aseptically divided into about 3 grams per box.

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Abstract

The invention discloses eye ointment for treating fungal keratitis. The eye ointment is a mixture containing terbinafine hydrochloride and atropine. The eye ointment solves the problems that the anti-fungal eye medicine lacks and the conventional anti-fungal eye drop is expensive and short in persistence time in eyes, has a poor anti-fungal curative effect and cannot relieve secondary iridocyclitis of the fungal keratitis and the like. The invention has the advantages that: the eye ointment has long persistence time in the eyes and an obvious anti-fungal curative effect, the effective rate reaches 98 percent, and the eye ointment has a treatment effect on the secondary iridocyclitis, obviously relieves the eye pain symptom of a patient and does not have obvious toxic or side effect; the preparation method is simple, and has the feasibility of industrialized production; and the eye ointment is expected to play an important role in treating the clinical fungal keratitis.

Description

technical field [0001] The invention relates to an ophthalmic ointment, in particular to an ophthalmic ointment for treating fungal keratitis. Background technique [0002] Fungal keratitis is an infectious corneal disease caused by pathogenic fungi with a high rate of blindness. Fungal keratitis is difficult to diagnose clinically, is easy to be misdiagnosed, and often causes blindness due to improper treatment. Under normal circumstances, fungi will not invade the normal cornea, but when there are ocular trauma, long-term topical antibiotics, corneal inflammation, and dry eye syndrome, non-pathogenic fungi may become pathogenic bacteria, causing secondary corneal fungal infection. The common pathogens are Aspergillus, followed by Fusarium, Candida albicans, Cephalosporium and Streptomyces. Due to different pathogenic bacteria, corneal ulcers have different shapes. Fungal keratitis is not uncommon. The incidence rate is high in the busy season of summer and autumn. In...

Claims

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Application Information

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IPC IPC(8): A61K31/46A61K9/06A61P27/02A61P31/10A61K31/137
Inventor 张璐
Owner HARBIN MEDICAL UNIVERSITY
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