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Preparation method of squalene synthetase inhibitor CJ-13982

A technology of CJ-13982 and compound, applied in the field of medicine and biology, can solve the problems of obtaining the compound CJ-13982 reported or not, and achieve the effects of simple and easy medium preparation, mild culture conditions and large yield

Inactive Publication Date: 2012-06-27
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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Problems solved by technology

[0009] But so far, in the literature reports at home and abroad, there is no report of obtaining compound CJ-13982 from other ways

Method used

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  • Preparation method of squalene synthetase inhibitor CJ-13982
  • Preparation method of squalene synthetase inhibitor CJ-13982
  • Preparation method of squalene synthetase inhibitor CJ-13982

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Embodiment 1

[0022] 1. Isolation, purification and identification of plant endophytic fungus Nigrospora oryzae A8.

[0023] The rice black spore (Nigrospora oryzae) A8 of the present invention is an endophytic fungus isolated from the 5-year-old root and 30-year-old fragrant part of the medicinal plant Acacia sinensis collected from Guangdong Xinyi. It is identified by ITS sequence analysis, and its ITS region The base sequence of the fragment is shown as SEQ ID NO.1, and the GenBank gene accession number is: EU781665 [Isolation and Molecular Identification of Endophytic Fungus A. chinensis, Fungal Research, 2009, 7(1), 37-42]. According to blast comparison and homologous analysis, the bacterial strain of the present invention belongs to Nigrospora oryzae species, and is named as Nigrospora oryzae A8. The bacterium was preserved in China Center for Type Culture Collection (CCTCC) on November 24, 2011, address: China. Wuhan. Wuhan University, and its preservation number is CCTCC NO: M 20114...

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Abstract

The invention discloses a preparation method of a squalene synthetase inhibitor CJ-13982. The compound CJ-13982 is separated and prepared from a fermentation culture of nigrospora oryzae A8 which has a collection number of CCTCC NO. M 2011412. The invention provides a method for preparing the compound CJ-13982 with the squalene synthetase inhibiting effect from the fermentation culture of a plant endophytic fungi nigrospora oryzae A8. The method is advantaged in mild culturing condition, simple and feasible culturing medium preparation, simple separation and purification steps, and high yield. With the method, large-scale production can be realized in a manual controlling condition. With the method, a problem of raw material required by compound CJ-13982 researches or applications can easily be solved, and a novel approach is provided for the preparation of the compound CJ-13982.

Description

technical field [0001] The invention belongs to the technical field of medicine and biology, and specifically relates to a method for preparing compound CJ-13982, which has the function of inhibiting squalene synthase, by using plant endophytic fungus Nigrospora oryzae A8 to ferment. Background technique: [0002] With the aging of my country's population, the morbidity and mortality of cardiovascular diseases are increasing year by year, and coronary heart disease is the main killer among them. We often say that coronary heart disease is mostly caused by organic stenosis or blockage of arteries, also known as coronary atherosclerotic heart disease. The stenosis of coronary arteries is mostly caused by the accumulation of fatty substances along the inner wall of blood vessels. hardening. When arteriosclerosis develops to a certain extent, coronary artery stenosis gradually increases, restricting blood flow into the myocardium. When the heart doesn't get enough oxygen, ches...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/64C07C59/245C07C51/42C12R1/645
Inventor 李冬利王磊章卫民
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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