Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof

A nanofiber, nanofiber membrane technology, applied in spinning solution preparation, medical science, heating/cooling fabric, etc., can solve the problems of single chemical composition of nanofibers, limitation of mechanical properties, less than 20% of artificial bone market, etc. Achieve good biological activity, biocompatibility, and high mechanical strength

Inactive Publication Date: 2012-06-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far bone repair still mainly uses autologous bone and allogeneic bone, and artificial bone accounts for less than 20% of the bone repair material market
However, the mechanical properties of these nanofibers are limited due to their single chemical composition, which is either composed of inorganic calcium phosphate or organic collagen.

Method used

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  • Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof
  • Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof
  • Calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and preparation method thereof

Examples

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Effect test

Embodiment 1

[0060] The preparation of embodiment 1 disordered calcium phosphate nanofiber film

[0061] 5 g Ca(NO 3 ) 2 4H 2 O and 2 g (NH 4 ) 2 HPO 4 Add 100 ml of ethanol and water in a mixed solvent with a ratio of 4:1 to form a solution, add hydrochloric acid to adjust the pH to 3, and stir for 24 hours; add 3 grams of polyvinylpyrrolidone with a weight average molecular weight of 1,300,000 to the above solution Continue stirring for 1 hour to obtain a hydroxyapatite precursor electrospinning solution; transfer the electrospinning solution to the electrospinning container 1 carrying the spinning solution in the special equipment for electrospinning with a piston type input pump 2 , the electrospinning solution at the spinning port 3 is subjected to the action of a high-voltage electric field to form a liquid electrospinning jet 7, which is continuously refined in the electric field, and at the same time, the solvent in the jet volatilizes rapidly, and finally on the flat receivin...

Embodiment 2

[0062] Example 2 Preparation of Axial Array Calcium Phosphate Nanofiber Membrane

[0063] This example adopts the axial receiving drum 6 in the special equipment to receive the electrospinning nanofiber (at this moment, the flat receiving electrode plate 5 is changed into the axial receiving drum 6 and gets final product), and the rotating drum speed is 2000 rev / min. The collected axial array electrospun fibers were put into a box-type resistance furnace and roasted at a high temperature of 1000°C for 6 hours to remove organic components. The other preparation conditions were the same as in Example 1, and an axial array of hydroxyapatite nanofiber membranes was obtained as a result. , with an average diameter of 260 nm, such as image 3 shown.

Embodiment 3

[0064] Preparation of Example 3 Disordered Calcium Phosphate Nanofiber Membrane

[0065] Using Ca(NO 3 ) 2 4H 2 O:(NH 4 ) 2 HPO 4 ) molar ratio was 1.5, and other preparation conditions were the same as in Example 1 to obtain a tricalcium phosphate nanofibrous membrane with an average diameter of 350 nanometers.

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Abstract

The invention discloses a calcium phosphate-collagen nanometer fiber compound nanometer artificial bone and a preparation method thereof. A calcium phosphate nanometer fiber film serves as a nanometer structural unit and combines with collagen to form the compound nanometer artificial bone; or a collagen nanometer fiber film serves the nanometer structural unit and combines with the calcium phosphate to form the compound nanometer artificial bone. The preparation method comprises the steps of preparing the calcium phosphate nanometer fiber film and collagen nanometer fiber film by using a static spinning device; and alternatively combining with collagen or calcium phosphate after taking the calcium phosphate nanometer fiber film or collagen nanometer fiber film as the nanometer structural unit to form the calcium phosphate-collagen nanometer fiber compound nanometer artificial bone. The compound nanometer artificial bone disclosed by the invention at least comprises one nanometer fiber in calcium phosphate or collagen, has biologic activity, biological compatibility and biomechanic intensity and can be used for repairing defects parts of weight bearing bones, including skulls, limb-stem bones, orofacial bones, vertebral columns and the like and serving as gradient materials to repair the connection parts of cartilages and bones.

Description

technical field [0001] The invention relates to a biomedical material and its preparation technology, in particular to a nanoartificial bone composed of calcium phosphate nanofibers and collagen nanofibers, and a method for preparing the composite nanoartificial bone, belonging to the field of biomedical materials. Background technique [0002] Bone-joint system injury is a major disease that threatens human health. 80% of its patients need to use biomedical materials, and orthopedic biomedical materials and implant devices have accounted for 37% of the high-tech biomaterials market. But so far bone repair still mainly uses autologous bone and allogeneic bone, and artificial bone accounts for less than 20% of the bone repair material market. However, the sources of autologous bone and allogeneic bone are limited, and there may be risks of immune rejection and disease infection. Therefore, the development of artificial bone has always been the main direction for the developme...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/24A61L27/12D04H1/42D04H1/4209D04H1/728D06C7/00D01D1/02
Inventor 洪友良王哲张兴栋
Owner SICHUAN UNIV
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