Preparation method of Ainsliaea lactone substances
A technology of rabies and esters, which is applied in the field of preparation of rabies lactones, can solve the problems of long heating time of effective active ingredients, unstable ingredients, long time consumption, etc., and achieves easy control of operating parameters and extraction time Fast, low temperature effect
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Embodiment 1
[0013] Take the medicinal material of the genus Tuerfeng long handle Tuerfeng and crush it. Under the conditions of pressure 20MPa and temperature 45°C, 80% methanol is introduced as an entrainer to participate in the extraction for 180min. The temperature of the desorption kettle is set at 12°C and the pressure is 18MPa. , add an appropriate amount of ethanol to disperse, oscillate evenly, add 3% activated carbon to reflux for decolorization, extract the decolorization solution twice with 2 times the amount of ether, combine the ether extracts, dehydrate with anhydrous sodium sulfate, concentrate under reduced pressure, and dry to obtain argolide Substances, of which the total content of umbelliferone, terpene, ainsliadimer A, and gochnatiolide A reaches more than 60%.
Embodiment 2
[0015] Take the thin-leaved rabbit-leaf genus Tuerfeng and pulverize it. Under the conditions of pressure 40MPa and temperature 30°C, inject 80% ethanol as an entrainer to participate in the extraction for 90min. Set the temperature of the desorption kettle to 25°C and the pressure to 6MPa, and collect the analyte. , add an appropriate amount of ethanol to disperse, oscillate evenly, add 1% activated carbon to reflux for decolorization, extract the decolorization solution with an equal amount of ether for 4 times, combine the ether extracts, dehydrate with anhydrous sodium sulfate, concentrate under reduced pressure, and dry to obtain rabies. Substances, of which the total content of umbelliferone, terpene, ainsliadimer A, and gochnatiolide A reaches more than 60%.
Embodiment 3
[0017] Take Tuerfeng medicinal material Biandi Tuerfeng and grind it. Under the conditions of pressure 30MPa and temperature 40℃, 80% isopropanol was introduced as an entrainer to participate in the extraction for 100min. The analytical solution was dispersed by adding an appropriate amount of ethanol, oscillated evenly, and then refluxed with 2% activated carbon for decolorization. The decolorized solution was extracted three times with 1.5 times the amount of ether, and the ether extracts were combined, dehydrated with anhydrous sodium sulfate, concentrated under reduced pressure, and dried to obtain Tuerfeng Lactone substances, of which the total content of umbelliferone, terpene, ainsliadimer A, and gochnatiolide A reaches more than 60%.
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