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Medicinal composition for treating chronic cough of children and its preparation method

A composition and drug technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of unfavorable quality control, excessive dosage, easy mildew and bacterial contamination, etc., and achieve significant economic and social benefits, reduced doses for patients, and improved bioavailability

Active Publication Date: 2012-06-06
津药达仁堂集团股份有限公司达仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The preparation method of the drug is simple, but the original formulation is a honeyed pill, which is prone to mildew and bacterial contamination, which is not conducive to quality control
It is inconvenient for patients to take and carry, the taste is not good, each pill weighs 3 grams, and the dosage of each dose is too large, children have difficulty swallowing, and the patient's acceptance is poor
And the absorption process from oral administration to the gastrointestinal tract is slow

Method used

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  • Medicinal composition for treating chronic cough of children and its preparation method
  • Medicinal composition for treating chronic cough of children and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: preparation of Chinese medicine extract

[0025] 1. Prescription: 400g of gypsum, 200g of loquat leaves, 200g of Zhuru, 200g of mulberry leaves, 100g of Pinellia fragrans, 100g of coltsfoot flowers, 100g of mulberry alba, 100g of Tinglizi, 20g of calamus, 100g of sea pumice (calcined), husk 50g incense, 100g perilla seeds (stir-fried), 50g honeysuckle, 100g bitter almonds (stir-fried), 20g agarwood, 100g silkworm (stir-fried), 6g ephedra.

[0026] Two. Preparation method:

[0027] Take each raw material according to the ratio of raw materials; Tinglizi, Huoxiang, perilla (stir-fry), honeysuckle, bitter almond (fry), agarwood with 10 times the volume, 8 times the volume percentage concentration of 60% ethanol Alcohol extraction 2 times, 2 hours each time, combined alcohol extracts, concentrated to a relative density of 1.05 at 50-60°C, to obtain concentrated solution A; the rest of the medicinal flavors were extracted 2 times with 10 times the amount of wa...

Embodiment 2

[0028] Embodiment 2: preparation of Chinese medicine extract

[0029]1. Prescription: 400g of gypsum, 200g of loquat leaves, 200g of Zhuru, 200g of mulberry leaves, 100g of Pinellia fragrans, 100g of coltsfoot flowers, 100g of mulberry alba, 100g of Tinglizi, 20g of calamus, 100g of sea pumice (calcined), husk 50g incense, 100g perilla seeds (stir-fried), 50g honeysuckle, 100g bitter almonds (stir-fried), 20g agarwood, 100g silkworm (stir-fried), 6g ephedra.

[0030] Two. Preparation method:

[0031] Take each raw material according to the ratio of raw materials; Tinglizi, Huoxiang, perilla (stir-fry), honeysuckle, bitter almond (stir-fry), agarwood with 8 times the volume, 6 times the volume percentage concentration of 70% ethanol Alcohol extraction 2 times, 1.5 hours each time, combined alcohol extracts, concentrated to a relative density of 1.05 under the condition of 50-60°C, to obtain concentrated solution A; the remaining medicinal flavors were extracted 2 times with wa...

Embodiment 3

[0032] Embodiment 3: preparation of Chinese medicine extract

[0033] 1. Prescription: 400g of gypsum, 200g of loquat leaves, 200g of Zhuru, 200g of mulberry leaves, 100g of Pinellia fragrans, 100g of coltsfoot flowers, 100g of mulberry alba, 100g of Tinglizi, 20g of calamus, 100g of sea pumice (calcined), husk 50g incense, 100g perilla seeds (stir-fried), 50g honeysuckle, 100g bitter almonds (stir-fried), 20g agarwood, 100g silkworm (stir-fried), 6g ephedra.

[0034] Two. Preparation method:

[0035] Take each raw material according to the ratio of raw materials; Tinglizi, Huoxiang, perilla (stir-fried), honeysuckle, bitter almond (stir-fried), agarwood with 10 times the volume percentage concentration of 60% ethanol alcohol extraction 2 times , 1.5 hours each time, combine the alcohol extracts, concentrate to a relative density of 1.06 under the condition of 50-60°C, and obtain the concentrated solution A; the remaining medicinal flavors are extracted 2-3 times with 10 time...

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Abstract

Belonging to the field of modernization of traditional Chinese medicines, the invention discloses a medicinal composition for treating chronic cough of children and its preparation method. The active components of the medicinal composition for treating chronic cough of children are prepared by the following raw materials by weight: 400 parts of gypsum, 200 parts of loquat leaves, 200 parts of bamboo shavings, 200 parts of mulberry leaves, 100 parts of rhizoma pinellinae praeparata, 100 parts of tussilago farfara, 100 parts of mulberry bark, 100 parts of semen lepidii, 20 parts of acorus gramineus, 100 parts of pumice (calcined), 50 parts of wrinkled gianthyssop herbs, 100 parts of perilla seeds (stir-fried), 50 parts of honeysuckle stems, 100 parts of bitter apricot kernels (stir-fried), 20 parts of agilawood, 100 parts of stiff silkworms (stir-fried), and 6 parts of ephedra. The medicinal composition of the invention has the advantages of: stable and controllable quality, substantially improved curative effect compared with existing sold preparation forms, reduced taking dosage by patients, enhanced bioavailability, as well as obvious economic and social benefits.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating chronic cough in children and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] Chronic cough in children is a common clinical disease, characterized by recurrent cough and persistent cough. Seriously affect children's health and growth and development. Cough is mostly a disease based on the lung meridian, but it is closely related to the spleen, kidney and other viscera. In children, the viscera are delicate, the qi and blood are not filled, and the interstitial tissue is not dense. After exogenous pathogenic factors, it is easy to damage the lung qi. Prolonged cough will cause qi and yin Two injuries affect the transportation and transformation function of the spleen. When clearing and moistening the lungs, transporting the spleen and removing dampness. [0003] Traditional Chinese medicine believes tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P11/14A61P11/10A61K33/00A61K33/06A61K35/64
Inventor 潘勤闫晓楠江永萍宋立平李妍
Owner 津药达仁堂集团股份有限公司达仁堂制药厂
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