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Pharmaceutical composition for treating children's long-term cough and preparation method thereof

A composition and drug technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of unfavorable quality control, excessive dosage, easy mildew and bacterial contamination, etc., and achieve significant economic and social benefits, reduced doses for patients, and improved bioavailability

Inactive Publication Date: 2012-06-06
津药达仁堂集团股份有限公司达仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The preparation method of the drug is simple, but the original formulation is a honeyed pill, which is prone to mildew and bacterial contamination, which is not conducive to quality control
It is inconvenient for patients to take and carry, the taste is not good, each pill weighs 3 grams, and the dosage of each dose is too large, children have difficulty swallowing, and the patient's acceptance is poor
And the absorption process from oral administration to the gastrointestinal tract is slow

Method used

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  • Pharmaceutical composition for treating children's long-term cough and preparation method thereof
  • Pharmaceutical composition for treating children's long-term cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: preparation of Chinese medicine extract

[0025] 1. Prescription: 400g of gypsum, 200g of loquat leaves, 200g of Zhuru, 200g of mulberry leaves, 100g of Pinellia fragrans, 100g of coltsfoot flowers, 100g of mulberry alba, 100g of Tinglizi, 20g of calamus, 100g of sea pumice (calcined), husk 50g incense, 100g perilla seeds (stir-fried), 50g honeysuckle, 100g bitter almonds (stir-fried), 20g agarwood, 100g silkworm (stir-fried), 6g ephedra.

[0026] Two. Preparation method:

[0027] Extract all the medicinal materials twice with 10 times and 8 times the amount of water respectively, for 2 hours each time, combine the extracts, concentrate to a relative density of 1.05 at 50-60°C, and obtain a concentrated solution; decompress the concentrated solution Dry to obtain a dried product, which is 950 grams of the active ingredient of the present invention.

Embodiment 2

[0028] Embodiment 2: preparation of Chinese medicine extract

[0029] 1. Prescription: 400g of gypsum, 200g of loquat leaves, 200g of Zhuru, 200g of mulberry leaves, 100g of Pinellia fragrans, 100g of coltsfoot flowers, 100g of mulberry alba, 100g of Tinglizi, 20g of calamus, 100g of sea pumice (calcined), husk 50g incense, 100g perilla seeds (stir-fried), 50g honeysuckle, 100g bitter almonds (stir-fried), 20g agarwood, 100g silkworm (stir-fried), 6g ephedra.

[0030] Two. Preparation method:

[0031] Extract all the medicinal materials twice with 10 times the amount of water, 1.5 hours each time, combine the extracts, concentrate to a relative density of 1.08 at 50-60°C to obtain a concentrated solution; dry the concentrated solution under reduced pressure to obtain a dry product , which is 400 grams of the active ingredient of the present invention.

Embodiment 3

[0032] Embodiment 3: preparation of Chinese medicine extract

[0033] 1. Prescription: 400g of gypsum, 200g of loquat leaves, 200g of Zhuru, 200g of mulberry leaves, 100g of Pinellia fragrans, 100g of coltsfoot flowers, 100g of mulberry alba, 100g of Tinglizi, 20g of calamus, 100g of sea pumice (calcined), husk 50g incense, 100g perilla seeds (stir-fried), 50g honeysuckle, 100g bitter almonds (stir-fried), 20g agarwood, 100g silkworm (stir-fried), 6g ephedra.

[0034] Two. Preparation method:

[0035] Extract all the medicinal materials with 8 times the amount of water for 3 times, each time for 1 hour, combine the extracts, concentrate to a relative density of 1.06 at 50-60°C to obtain a concentrated solution; spray dry the concentrated solution to obtain a dry product , which is 900 grams of the active ingredient of the present invention.

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Abstract

The invention discloses a pharmaceutical composition for treating a children's long-term cough and a preparation method thereof, and belongs to the field of modernization. The pharmaceutical composition for treating a children's long-term cough is prepared from 400 parts by weight of gypsum, 200 parts by weight of loguat leaf, 200 parts by weight of bamboo shavings, 200 parts by weight of mulberry leaf, 100 parts by weight of rhizoma pinellinae praeparata, 100 parts by weight of common coltsfoot flower, 100 parts by weight of white mulberry root-bark, 100 parts by weight of seed of pepperweed, 20 parts by weight of grassleaf sweelflag rhizome, 100 parts by weight of calcined bryozoatum, 50 parts by weight of wrinkled giant hyssop, 100 parts by weight of fried fructus perillae, 50 parts by weight of caulis lonicerae, 100 parts by weight of fried semen armeniacae amarae, 20 part by weight of agilawood, 100 parts by weight of fried muscardine silkworm and 6 parts by weight of herbal ephedrae. The pharmaceutical composition for treating a children's long-term cough has advantages that quality is stable and controllable; curative effects are obviously higher than curative effects of the same type of the existing pharmaceutical composition on the market; a taking dosage is reduced; bioavailability is improved; and economic and social benefits are remarkable.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating chronic cough in children and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] Chronic cough in children is a common clinical disease, characterized by recurrent cough and persistent cough. Seriously affect children's health and growth and development. Cough is mostly a disease based on the lung meridian, but it is closely related to the spleen, kidney and other viscera. In children, the viscera are delicate, the qi and blood are not filled, and the interstitial tissue is not dense. After exogenous pathogenic factors, it is easy to damage the lung qi. Prolonged cough will cause qi and yin Two injuries affect the transportation and transformation function of the spleen. When clearing and moistening the lungs, transporting the spleen and removing dampness. [0003] Traditional Chinese medicine believes tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P11/14A61K33/00A61K33/06A61K35/64
Inventor 潘勤李燕钰闫晓楠刘雅华刘稚菲
Owner 津药达仁堂集团股份有限公司达仁堂制药厂
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