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Chinese medicinal composition for nourishing yin, clearing heat, and moistening lung for arresting cough, and its preparation method

A technology for nourishing yin and clearing heat, and a composition, which is applied in the directions of drug combination, drug delivery, and pharmaceutical formulation, can solve problems such as unfavorable quality control, excessive dosage, and poor patient acceptance, and achieve significant economic and social benefits. Reduced dosage, excellent expectorant and antitussive effect

Active Publication Date: 2013-06-26
津药达仁堂集团股份有限公司达仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the original formulation is honeyed pills, which are prone to mildew and bacterial contamination, which is not conducive to quality control
It is inconvenient for patients to take and carry, the taste is not good, each pill weighs 9 grams, and the dosage of each dose is too large, children, the elderly and patients with pharyngitis have difficulty swallowing, and the patient's acceptance is poor
And the absorption process from oral administration to the gastrointestinal tract is slow
These factors directly affect the clinical application of Yulu Baofei Pills, and these factors have affected the clinical application of the drug

Method used

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  • Chinese medicinal composition for nourishing yin, clearing heat, and moistening lung for arresting cough, and its preparation method
  • Chinese medicinal composition for nourishing yin, clearing heat, and moistening lung for arresting cough, and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: preparation of Chinese medicine extract

[0025] 1. Prescription: Asparagus 120g, Ophiopogon japonicus 120g, Dendrobium 80g, Rehmannia glutinosa 80g, Rehmannia glutinosa 80g, Anemarrhena 40g, Phellodendron 40g

[0026] Two. Preparation method:

[0027] Weigh each raw material according to the ratio of raw materials, and set aside; all the medicinal materials are extracted with 10 times and 8 times of water respectively, each time for 2 hours, and the extracts are combined, concentrated to a relative density of 1.03 at 50-60°C, and concentrated solution A is obtained. ; Add ethanol with a volume percentage concentration of 95% to the concentrated solution A, precipitate and stand still, so that the volume percentage concentration of ethanol in the supernatant B is 40%. Concentrate the supernatant B to a relative density of 1.05 at 50-60°C to obtain a concentrate C; dry the concentrate C under reduced pressure or spray to obtain a dry product, which is 127 ...

Embodiment 2

[0028] Embodiment 2: preparation of Chinese medicine extract

[0029] 1. Prescription: Asparagus 1200g, Ophiopogon japonicus 1200g, Dendrobium 800g, Rehmannia glutinosa 800g, Rehmannia glutinosa 800g, Anemarrhena 400g, Phellodendron 400g

[0030] Two. Preparation method:

[0031]Weigh each raw material according to the raw material ratio, and set aside; extract all the medicinal materials with 10 times and 12 times the amount of water, each time for 2 hours, combine the extracts, concentrate until the relative density is 1.05 under the condition of 50-60°C, and obtain the concentrated solution A; Add ethanol with a volume percentage concentration of 95% to the concentrated solution A, precipitate and stand still, so that the volume percentage concentration of the supernatant B is 50%. Concentrate the supernatant B to a relative density of 1.05 at 50-60°C to obtain a concentrate C; dry the concentrate C under reduced pressure or spray to obtain a dry product, which is 1765 gra...

Embodiment 3

[0032] Embodiment 3: preparation of Chinese medicine extract

[0033] 1. Prescription: Asparagus 120g, Ophiopogon japonicus 120g, Dendrobium 80g, Rehmannia glutinosa 80g, Rehmannia glutinosa 80g, Anemarrhena 40g, Phellodendron 40g

[0034] Two. Preparation method:

[0035] Weigh each raw material according to the raw material ratio, and set aside; all the medicinal materials are extracted with 12 times and 10 times of water, each time for 1.5 hours, and the extracts are combined, concentrated to a relative density of 1.08 under the condition of 50-60 ° C, and the concentrated solution A is obtained. ; Add ethanol with a concentration of 95% by volume to the concentrated solution A, precipitate and let it stand, so that the concentration of ethanol by volume in the supernatant B is 60%. Concentrate the supernatant liquid B to a relative density of 1.08 at 50-60°C to obtain a concentrated liquid C; dry the concentrated liquid C under reduced pressure or by spray drying to obtai...

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Abstract

Belonging to the field of modernization of traditional Chinese medicine, the invention discloses a Chinese medicinal composition for nourishing yin, clearing heat, and moistening lung for arresting cough, and its preparation method. The active components of the Chinese medicinal composition for nourishing yin, clearing heat, and moistening lung for arresting cough are prepared by the following raw materials by weight: 120 parts of Radix Asparagi, 120 parts of Ophiopogon japonicus, 80 parts of dendrobium, 80 parts of rehmanniae, 80 parts of prepared rehmanniae, 40 parts of rhizoma anemarrhenae, and 40 parts of phellodendron. The Chinese medicinal composition provided in the invention has the advantages of stable and controllable quality, substantially improved curative effects compared to present market dosage forms, reduced oral administration dosage for patients, and enhanced bioavailability, thus boasting remarkable economic and social benefits.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for nourishing yin, clearing heat, moistening lung and relieving cough and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] Cough is a common and frequent symptom of respiratory diseases. Cough is caused by external stimulation acting on the vagus nerve and stimulating AP in cough. There are many reasons for stimulating the vagus nerve, including ①respiratory tract infection: inflammation caused by viruses, bacteria, mycoplasma, fungi, and parasites; Heart disease, pericarditis and pericardial effusion, irritating dry cough due to stimulation of the cardiac branch of the vagus nerve; ④ Tumor; ⑤ Allergic factors; ;⑦After the infection is controlled, if the respiratory tissue damage and blood circulation disorder do not improve, the damaged part will stimulate the PG in the cough to cause cough through the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/48A61K9/00A61K36/8984A61P11/14A61P11/04A61P11/10A61P11/00A61P31/06
Inventor 张平潘勤金兆祥刘雅华江永萍项芳
Owner 津药达仁堂集团股份有限公司达仁堂制药厂
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