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Preparation method and application of ginseng fruit medicinal dispersing tablets and buccal tablets

A technology of dispersible tablets and ginseng fruit, which is applied to diseases with deficiency of heart and spleen, and treats the field of deficiency of qi and yin, and achieves the effect of high bioavailability and fast absorption.

Inactive Publication Date: 2012-06-06
JILIN JICHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, ginseng fruit has not been widely developed and utilized as a medicinal material. It is very important to study efficient and economical extraction methods; it is very important to prepare new dosage forms of traditional Chinese medicine that are convenient to take orally and have high bioavailability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The extraction and preparation process of the medicine of the present invention is as follows: (1) Break 5 kg of dried ginseng fruit into tiny blocks, add 8 times the amount of water to decoct 3 times, each time for 1.5 hours, filter, and combine the filtrates. (2) Clear paste concentrated to a relative density of 1.05 (60°C). (3) Add 40% and 70% ethanol in sequence, let stand at 5°C for 12 hours, filter, and combine the filtrate; recover the alcohol from the filtrate and dilute it with water to a clear paste with a relative density of 1.35 (60°C), dry, and ultrafinely pulverize , to obtain about 650g of the main ingredient superfine powder. (4) Precisely weigh 100g of the main superfine powder, add appropriate amount of auxiliary materials, mix well, and make dispersible tablets / lozenges.

[0047] Wherein, the adjuvants adopted in the dispersible tablet are respectively calcium sulfate 30g, cross-linked polyvinylpyrrolidone 4g, 10% polyvinylpyrrolidone K30 aqueous sol...

Embodiment 2

[0049] The extraction and preparation process of the medicine of the present invention is as follows: (1) Break 5 kg of dried ginseng fruit into tiny blocks, add 8 times the amount of water to decoct 3 times, each time for 1.5 hours, filter, and combine the filtrates. (2) Clear paste concentrated to a relative density of 1.10 (60°C). (3) Add 50% and 70% ethanol in turn, let stand at 8°C for 24 hours, filter, and combine the filtrate; recover the alcohol from the filtrate and dilute with water to a clear paste with a relative density of 1.36 (60°C), dry, and ultrafinely pulverize , to obtain the main drug superfine powder. (4) Add appropriate amount of auxiliary materials, mix well, and make dispersible tablets / lozenges, that is, ready.

[0050] Wherein, the adjuvants adopted in the dispersible tablet are respectively calcium sulfate 40%, cross-linked polyvinylpyrrolidone 6%, 10% polyvinylpyrrolidone K30 aqueous solution 4%, Tween- 80 0.4%, micropowder silica gel 4%; the adju...

Embodiment 3

[0052] The extraction and preparation process of the medicine of the present invention is as follows: (1) Break 5 kg of dried ginseng fruit into tiny blocks, add 8 times the amount of water to decoct 3 times, each time for 1.5 hours, filter, and combine the filtrates. (2) Clear paste concentrated to a relative density of 1.15 (60°C). (3) Add 60% and 70% ethanol in sequence, let stand at 10°C for 48 hours, filter, and combine the filtrate; recover the alcohol from the filtrate and dilute it with water to a clear paste with a relative density of 1.37 (60°C), dry, and ultrafinely pulverize , to obtain the main drug superfine powder. (4) Add appropriate amount of auxiliary materials, mix well, and make dispersible tablets / lozenges, that is, ready.

[0053] Wherein, the adjuvants adopted in the dispersible tablet are respectively calcium sulfate 50%, cross-linked polyvinylpyrrolidone 8%, 10% polyvinylpyrrolidone K30 aqueous solution 6%, Tween- 80 0.6%, micronized silica gel 6%; t...

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Abstract

The invention relates to a method for extracting a ginseng fruit effective component for preparing dispersing tablets / buccal tablets. The invention also relates to an application method of the dispersing tablets and buccal tablets prepared from a ginseng fruit extract in treating a qi-yin asthenia disease and a heart-spleen deficiency disease. A preparation method of the tablets comprises steps of crushing, decocting, alcohol extracting, filtrate combing, clear past condensing, drying, and ultra-fine crushing. With the steps, main medicine ultra-fine powder is obtained; auxiliary materials are added to the powder, the mixture is well mixed, and is prepared into the dispersing tablets / buccal tablets. The preparation method is more efficient and saving. According to the invention, the ginseng fruit extract dispersing tablets / buccal tablets has functions of qi benefiting, body fluid generating, yin nourishing and dryness moisturizing. The tablets are used for treating the qi-yin asthenia disease and the heart-spleen deficiency disease.

Description

technical field [0001] The present invention relates to a method for preparing dispersible tablets / buccal tablets by extracting the active ingredients of ginseng fruit, and the invention also relates to a dispersible tablet / buccal tablet prepared by using ginseng fruit extracts in the treatment of diseases of deficiency of both qi and yin, and deficiency of both heart and spleen Applications. Background technique [0002] Ginseng fruit has the reputation of "the king of anti-cancer". It is also good for Qi and body fluid, nourishing yin and moistening dryness. It is rich in various trace elements, and these trace elements such as selenium, iron, calcium, zinc and other elements can activate human cells , enhance human immunity, maintain the normal function of immune cells, promote the absorption and utilization of various vitamins and nutrients, and inhibit the fission of malignant tumor cells, playing an important decisive role. [0003] At present, ginseng fruit has not b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/20A61P1/14A61P3/10A61P25/20A61K131/00
Inventor 曲风采
Owner JILIN JICHUN PHARMA
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