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Ophthalmic composition and method for prevention of cloudiness/precipitation

A composition, an ophthalmological technology, applied in the field of precipitation, dry eye treatment agent, cloudiness caused by freezing and thawing

Active Publication Date: 2012-05-30
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, vitamin A, which is a fat-soluble vitamin, is very sensitive to air, light, heat, acid, metal ions, etc., and is extremely unstable especially in an aqueous solution, so it is difficult to stably mix it into ophthalmic compositions such as eye drops.

Method used

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  • Ophthalmic composition and method for prevention of cloudiness/precipitation
  • Ophthalmic composition and method for prevention of cloudiness/precipitation
  • Ophthalmic composition and method for prevention of cloudiness/precipitation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～48、 comparative example 1～3

[0105] Ophthalmic compositions (eye drops) having the compositions shown in Tables 1 to 11 were prepared, and the following evaluations were performed. The results are recorded together in the table.

[0106]

[0107] The ophthalmic composition (eye drops) was filled into ophthalmic containers made of polyethylene terephthalate (N=3), and the operation of freezing (-20°C) and thawing (25°C) was repeated 5 times , and evaluated according to the following criteria.

[0108] Evaluation benchmark

[0109] 5: At the 5th time, the liquid was clear and transparent without any turbidity or precipitation

[0110] 4: At the 4th time, the liquid was clear and transparent without any turbidity or precipitation.

[0111] But the 5th time produced cloudiness or precipitation

[0112] 3: At the third time, the liquid was clear and transparent without any turbidity or precipitation.

[0113] But the 4th time produced white turbidity or precipitation

[0114] 2: At the second time, the...

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Abstract

An ophthalmic composition characterized by comprising (A) vitamin A, (B) a polyoxyethylene polyoxypropylene glycol, and at least one component selected from (C) trometamol, (D) polyhydric alcohols, (E) saccharides, (F) phosphoric acid and salt thereof and (G) monovalent neutral salts.

Description

technical field [0001] The present invention relates to an ophthalmic composition containing vitamin A. In more detail, it relates to an ophthalmic composition that does not cause cloudiness or precipitation after freezing and thawing, and relates to an ophthalmic composition that is stable in appearance and prevents freezing of the composition. Method of cloudiness and precipitation caused by melting. It further relates to a therapeutic agent for dry eye syndrome containing vitamin A, which has a therapeutic effect on corneal and conjunctival damage. Background technique [0002] Vitamin A is attracting attention as an ingredient effective in the prevention or treatment of keratosis of the cornea, conjunctiva, or mucous membrane. In addition, in recent years, the effect of vitamin A on dry eye symptoms such as cornea and conjunctival xerosis has been reported. However, vitamin A, which is a fat-soluble vitamin, is very sensitive to air, light, heat, acid, metal ions, etc....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/07A61K47/02A61K47/10A61K47/18A61K47/26A61K47/34A61P27/02
CPCA61K9/0048A61K31/07A61P27/02A61K45/06A61K47/02A61K47/18A61K47/34
Inventor 筒井叶月三宅深雪小高明人井上智惠子田渊照人服部学
Owner LION CORP
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