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Compound, preparation method thereof and application thereof as feed additive

A compound, full-price feed technology, applied in the application field of feed additives, can solve the problems of unsuitable production and use, difficulty in extraction, excessive dosage of additives, etc., and achieve the effects of increasing nutrient absorption, slowing emptying speed, and reducing intestinal tension.

Active Publication Date: 2014-04-23
谢联金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these substances promote the proliferation of intestinal epithelial cells to a certain extent, they are not suitable for actual production and use due to excessive dosage or difficulty in extraction.

Method used

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  • Compound, preparation method thereof and application thereof as feed additive
  • Compound, preparation method thereof and application thereof as feed additive
  • Compound, preparation method thereof and application thereof as feed additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 compound of the present invention

[0031] according to figure 1 The synthetic route shown formulates the chemical synthesis process, and the steps are as follows:

[0032] (1) Add raw material Al: (S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-4-one 2.88kg (10mol) to 100L and heat for reaction In the kettle, add 60L of purified water and stir to dissolve. Circulating warm water to keep the internal temperature at 37°C, adding 0.01 mol of immobilized enzyme of flavanone-3-hydroxylase and incubating for 3 hours to obtain intermediate A2. After the reaction, the immobilized enzyme was recovered by filtration, and 20 L of dichloromethane was added to the aqueous solution of A2 for extraction. Add 0.5 kg of anhydrous sodium sulfate to the dichloromethane extract to dry, filter, and the filtrate is directly used in the next reaction.

[0033] (2) The intermediate A2 obtained in the previous step: taxifolin [(2R,3R)-2-(3,4-dihydroxyphenyl...

Embodiment 2

[0038] Embodiment 2 Molecular structure analysis of the compound of the present invention

[0039] (1) Infrared (IR): The instrument uses Nicolet IR200FT-IR infrared spectrometer;

[0040] IR(KBr)cm -1 : 3638, 3500-2600, 2958, 2871, 1768, 1498, 1434, 1361, 1230, 1189, 1145, 819.

[0041] (2) Mass spectrometry (MS): The instrument uses Finnigan MAT SSQ710 electrospray ionization mass spectrometer;

[0042] ESI / MS shows [M] + =479.25 and [M+Na] + =502.33.

[0043] (3) Nuclear Magnetic Resonance (NMR): The instrument adopts Bruker AV400MHz superconducting NMR instrument;

[0044] 1 H-NMR (DMSO-d 6 )δppm: 7.27, 7.29, 7.40 (5H, m, H-22, 23, 24, 25, 26), 6.93 (1H, s, H-11), 6.76 (1H, d, H-15), 6.71 ( 1H, d, H-14), 6.18 (1H, s, H-6), 5.83 (1H, s, H-2), 5.74 (1H, d, H-9), 5.35 (OH), 5.15 (2H , s, H-17), 5.01 (1H, d, H-8), 3.78 (1H, m, H-19), 2.26 (3H, s, H-16), 1.61 (3H, d, H-20 );

[0045] 13 C-NMR (DMSO-d 6 )δppm: 194.6, 173.7, 164.9, 163.8, 163.6, 146.2, 145.9, 135.4, ...

Embodiment 3

[0058] Select 72 healthy and disease-free Du×Chang×Da Sanyuan hybrid barrows with a body weight of about 35 kg [with Duroc boars as the male parents, crossing Landrace boars and Large White (Darkshire) sows] The second-generation hybrid pigs obtained by mating the remaining hybrid sows as female parents] were randomly divided into two treatment groups, the control group and the experimental group. There were 6 repetitions in each group, and each repetition was 6 heads. The control group was fed with full-price feed, and the experimental group was fed with the same full-price feed with 75 g / t of the compound of the present invention. The pre-test period is 7 days, and the trial period is 60 days. At the end of the growing period and the finishing period, the average daily feed intake, daily gain and feed-to-weight ratio in the growing period and the finishing period were counted respectively, and the results are shown in Table 3.

[0059] Table 3. Effects of compounds of the ...

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Abstract

The invention discloses a compound, namely (2R, 3R)-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxyl-4-oxo-2,3-dihydrobenzopyran-3-yl) methylamino) methyl-2-phenylpropionate. The invention also discloses a preparation method for the compound and the application of the compound as a feed additive. When serving as the feed additive, the compound can specifically promote the growth of intestinal mucosa villus of livestocks, promote the growth of intestinal linings, reduce the intestinal tension and inhibit abnormal peristalsis, can reduce the feed discharging speed of intestinal tracts of the livestocks so as to enhance the digestive absorption of the intestinal tracts to nutritional components, and can obviously increase the daily weight increasing of the livestocks. The reduction of the intestinal tension contributes to water absorption in the intestinal tracts, and plays an obvious role of convergence and reducing functional diarrhea. The compound provided by the invention also has an effect of repairing intestinal mucosa, and can also obviously improve the immunity function of intestinal mucosa and disease resistance of the livestocks.

Description

technical field [0001] The invention relates to a new compound and its application as a feed additive for nourishing and repairing intestinal mucosa of livestock and poultry, alleviating diarrhea and promoting growth. Background technique [0002] Healthy breeding is an objective requirement for the scientific and sustainable development of animal husbandry, and intestinal health is an important guarantee for healthy breeding. In the current intensive farming, due to factors such as improper management, stress, pathogen infection and feed, the mucosal barrier of the digestive tract of livestock and poultry is often damaged, resulting in immune function damage, bacterial displacement, and large-scale outbreaks of diseases. In order to prevent this kind of situation from happening, farmers are forced to add antibiotics in feed for a long time, which causes the problem of drug residues in animal products, affects the quality of animal products, and reduces the benefits of farme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/32C12P17/06A23K1/16A61P1/12A61P1/04
Inventor 谢联金
Owner 谢联金
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