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Calcium-binding agents induce hair growth and/or nail growth

A technology of calcium binding and compounding, applied in hair care, calcium organic compounds, manicure, etc., can solve problems such as large differences in results

Inactive Publication Date: 2012-05-02
RGT UNIV OF CALIFORNIA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Finasteride has also been utilized, but results vary widely

Method used

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  • Calcium-binding agents induce hair growth and/or nail growth
  • Calcium-binding agents induce hair growth and/or nail growth
  • Calcium-binding agents induce hair growth and/or nail growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0274] Calcium-binding peptides induce hair growth

[0275] figure 1 DSS-treated (right) and mock-treated (left) mice are shown showing hair regrowth 13 days after scalp shaving. figure 2 The effect of calcium-binding compounds on hair growth in mice is shown. Leftmost panels in each group show day 0 mice after preparation and before treatment. The panel on the right shows mice on day 23 (endpoint date). The upper panel shows a negative control that received daily topical saline treatment. The lower panel shows daily treated mice with a topical formulation of DSS compound applied to the indicated area, showing significant hair growth compared to controls.

Embodiment 2

[0277] Nucleation of hydroxyapatite on enamel and dentin via DSS peptide

[0278] To determine whether application of DSS to various tissue preparations promotes HA nucleation that can ultimately lead to tissue remineralization, sagittal sections of adult teeth (obtained after extraction from normal clinical practice) were ground using a Streurs wheel, Preparations for nuclear experiments. Half of the sections were demineralized with 35% phosphoric acid for 15 min and then rinsed thoroughly with deionized water. The other half is left alone. All samples were then sonicated to remove excess debris left over from cutting and grinding and / or demineralization. Samples were treated with 12.5 [mu]M 8DSS dissolved in 50 mM HEPES buffer solution (pH 7.0), buffer solution alone, or left untreated. The samples were then immersed in stimulating body fluid (SBFn) for 4 hours, ie, to accelerate the nucleation of hydroxyapatite (HA) crystals. After the nucleation step, the samples wer...

Embodiment 3

[0285] Tissue-specific binding of DSS peptides in human teeth

[0286] To investigate the tissue specificity of DSS peptide binding to tooth tissue, human tooth sections were exposed to DSS peptides and variants and then imaged by CLSM. The peptides used in these experiments were 8DSS, 8ASS, 8DAA, 8NAA, 4DSS, 4ESS, 4NSS, 4DTT, 4ETT, 4NTT and 6DSS. Sagittal sections of human teeth extracted during normal clinical practice were ground and then incubated for 10 minutes in a solution of the appropriate 5(6) carboxyfluorescein-labeled peptide (12.5 pM) containing 10 mM NaCl and 50 mM HEPES at pH 7.0. A control sample without peptide was prepared. Samples were thoroughly washed after treatment and imaged by CLSM using blue laser irradiation (A=488 nm) and FITC emission filters, using the same camera and microscope settings for each sample. For each slide, multiple scans were collected and combined in automatic mode to generate an image representing a 13x13 mm area, which in most...

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Abstract

This invention provides novel methods for inducing hair growth and / or inhibiting hair loss and / or inducing nail growth in a mammal. In various embodiments the methods involve administering, e.g., to a mammal in need thereof, a calcium-binding peptide and / or peptide-like moiety in an amount sufficient to induce hair growth and / or to inhibit hair loss. In certain embodiments the agent is topically and / or transdermally administered.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of and priority to USSN 61 / 150,623, filed February 6, 2009, which is hereby incorporated by reference in its entirety for all purposes. [0003] Statement of Rights to Inventions Made with Federal Sponsorship [0004] not applicable. [0005] REFERENCE TO SEQUENCE LISTINGS, TABLES OR COMPUTER PROGRAM LISTING ACCESSES FILLED ON DISK [0006] not applicable. field of invention [0007] The present invention generally relates to methods of promoting hair and / or nail growth in mammals, and more particularly to novel uses of calcium-binding peptides for promoting hair growth and / or reducing hair loss and / or inducing or increasing nail growth rate. Background of the invention [0008] Currently, effective treatments for androgenetic alopecia include finasteride (PROPECIA ) or minoxidil (6-(1-piperidinyl)-2,4-pyrimidinediamine, oral and topical formulations of 3-oxide (see, e.g., U.S. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/64C07F3/04A61Q7/00A61Q3/00A61K38/08
CPCA61Q3/00A61K8/64A61Q7/00A61Q11/00A61K38/08A61K38/10A61K38/16A61P1/02A61P17/00A61P17/14A61P19/08A61P19/10A61K49/0002
Inventor D·K·亚伯勒X·吴W·史M·安德森
Owner RGT UNIV OF CALIFORNIA
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