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Preparation method of three-dimensional porous support frame material containing carbon nanometer tubes

A technology of carbon nanotubes and scaffold materials, applied in medical science, prostheses, etc., can solve the problems of local tissue pH drop, aseptic inflammation, etc., and achieve good biocompatibility and osteoinductive effects

Inactive Publication Date: 2012-05-02
BEIHANG UNIV
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Problems solved by technology

However, the implantation of PLA, especially when the amount of implantation is large, is very likely to cause a significant drop in the pH value of the local tissue and cause adverse reactions such as aseptic inflammation.

Method used

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  • Preparation method of three-dimensional porous support frame material containing carbon nanometer tubes
  • Preparation method of three-dimensional porous support frame material containing carbon nanometer tubes
  • Preparation method of three-dimensional porous support frame material containing carbon nanometer tubes

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Embodiment Construction

[0027] The invention provides a class of three-dimensional porous scaffold materials containing carbon nanotubes CNTs in order to meet the demand for bone tissue defect repair caused by trauma, tumor, infection and the like. In addition to carbon nanotubes CNTs, the scaffold material also contains polylactic acid PLA and chitin fiber CHI, and the three components are compounded by combining physical mixing and ultrasonic dispersion.

[0028] After repeated experiments, it is determined that the optimal length of the chitin fiber CHI is 1.0-1.2 mm, and the optimal volume content of the chitin fiber CHI in the PLA mixture is 25-30%.

[0029] The carbon nanotubes CNTs need to be purified to remove impurities and cut to avoid agglomeration during mixing with PLA and CHI.

[0030] The chitin fiber CHI is cross-linked with polylactic acid PLA by a protein cross-linking agent N, N'-dicyclohexylcarboimide DCC so as to increase the reinforcing effect during the preparation of scaffold ...

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Abstract

The invention discloses a three-dimensional porous support frame material containing carbon nanometer tubes and a preparation method thereof, which belong to the technical field of biomedical materials. The support frame material consists of high-molecular-material polylactic acid (PLA), high-intensity fiber (CHI) and carbon nanometer tubes (CNTs), wherein the high-molecular-material PLA has good biocompatibility, the CHI is woven by natural polysaccharide chitin, and the CNTs have higher protein absorption capability, can promote cells to be differentiated in the sclerotin direction and is generated from bone tissues. A preparation process mainly comprises a method of combining physical mixing and ultrasound dispersion technology. In order to realize a better enhancing effect of the CHI, a protein cross linking reagent of N, N'-dicyclohexylcarbodiimide (DCC) is adopted for cross linking of the CHI and the PLA. The three-dimensional porous support frame material belongs to a novel support frame material used for bone restoring, has a three-dimensional porous structure, has good biocompatibility and bone inductivity, and is very hopeful to be widely used as bone tissue coloboma restoring materials clinically.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials. More precisely, the present invention relates to a three-dimensional porous scaffold material containing carbon nanotubes and a preparation method for bone tissue defect repair. Background technique [0002] Tissue engineering can achieve tissue regeneration. Scaffold materials for tissue engineering usually need to be prepared as three-dimensional porous materials to facilitate the growth of cells, blood vessels and tissues. Scaffold materials for bone tissue engineering also need to have certain mechanical properties. [0003] At present, more and more nanomaterials are used in biomedicine and even tissue engineering. One of the representative carbon nanotubes (CNTs) is receiving more and more attention due to its unique properties. So far, a large number of studies have shown that it can be used in biomedicine, especially with good compatibility with bone-related cells. Osteo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/44A61L27/08A61L27/18A61L27/20
Inventor 李晓明黄瑾牛旭峰樊瑜波
Owner BEIHANG UNIV
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