Bisphenol A dummy template molecularly imprinted stir bar and preparation method thereof

Abstract

The invention relates to a bisphenol A dummy template molecularly imprinted stir bar and a preparation method thereof. The stir bar is a glass bar containing an iron core, wherein the glass bar is coated by a polymer coating; the polymer coating is a bisphenol A dummy template molecularly imprinted polymer; modified silica microspheres with grain size being 400nm are taken as the carriers for synthesizing the imprinted polymer; and biphenyl diphenol is taken as a dummy template molecule. The bisphenol A dummy template molecularly imprinted polymer is prepared by carrying out surface grafting on the surfaces of silica microspheres with grain size being 400nm with vinyltrimethoxysilane to obtain the modified silica microspheres, then subjecting the modified silica microspheres to react withbiphenyl diphenol, 4-vinyl pyridine, ethylene glycol dimethacrylate and azodiisobutyronitrile and using a methanol-glacial acetic acid mixed solution to wash off the template molecule. The stir bar and the preparation method have the following beneficial effect that: SiO2 is taken as the carrier for synthesizing the imprinted polymer, thus greatly adding the number of the effective binding sites and improving the sensitivity.

Description

[0001] technical field [0002] The invention relates to a method for preparing a bisphenol A pseudo-template molecularly imprinted stirring rod. Background technique [0003] Stir bar sportive extraction (SBSE) is a new sample processing technology developed on the basis of solid-phase microextraction. It has attracted widespread attention due to its advantages of high sensitivity, easy operation and low solvent consumption. The enrichment process of the analyte in SBSE is based on the balanced distribution of the analyte between the sample and the coating. However, since the volume of the SBSE extraction phase is much larger than that of solid-phase microextraction, usually 50 to 250 times that of solid-phase microextraction, the enrichment factor is greatly improved. In addition, the stirring rod completes the adsorption of the analyte while stirring by itself, the operation is very simple, and it avoids the competitive adsorption of the stirring rod in solid phase micro...

AI Technical Summary

Problems solved by technology

[0004]However, since the only commercial stir bar coating is non-polar polydimethylsiloxane (Polydimethylsiloxane, PDMS) as the coating material , the adsorption of weakly polar or polar substances such as bisphenol A is very poor, so a derivatization step is often required before enriching such substances

This greatly increases the difficulty and uncertainty of the experimental operation, thus limiting the application of SBSE

Although many new materials and new methods have been introduced into the preparation of SBSE coatings, the effect of enriching polar substances such as estrogen and phenols in SBSE has been improved, but these coatings are all enriched for a certain type of substances, and still Does not have the ability to recognize specific molecular structures

Low specific selectivity is still the biggest defect of SBSE

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