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Medicinal composite preparation containing quinolones, preparation method thereof and application thereof

A technology of quinolones and compound preparations, which is applied in the field of quinolone-containing drug compound preparations and its preparation, which can solve the problems of animal refusal to eat, and achieve the effects of easy absorption, good dispersibility, and stable finished products

Active Publication Date: 2012-04-04
GENIFARM LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of medicine that can make animals normally use drugs according to the unpleasant feeling that the smell or taste of the drug itself brings to animals when using the existing quinolones, which will cause the animals to refuse to eat. Compound preparations containing quinolones that produce antifeedant due to odor or taste

Method used

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  • Medicinal composite preparation containing quinolones, preparation method thereof and application thereof
  • Medicinal composite preparation containing quinolones, preparation method thereof and application thereof
  • Medicinal composite preparation containing quinolones, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 359 g of enrofloxacin in a 5 L three-necked flask, add it into 1000 ml of anhydrous methanol, and start stirring. In addition, 118g of succinic acid was dissolved in 600ml of anhydrous methanol, which was added dropwise to the above-mentioned flask, heated to reflux for 4 hours, sampled for inspection, and after judging the end point of the reaction, the reaction was stopped, filtered, washed with anhydrous methanol, and dried to obtain 470g enrofloxacin succinate.

Embodiment 2

[0028] Put 361g of levofloxacin in a 5L three-neck flask, add in 1200ml of absolute ethanol, and start stirring. In addition, 192g of citric acid was dissolved in 750ml of absolute ethanol, which was added dropwise to the above-mentioned flask, heated to reflux for 5 hours, and sampled for inspection. After judging the end point of the reaction, stop the reaction, filter, wash with absolute ethanol, and dry to obtain 543g Levofloxacin citrate.

Embodiment 3

[0030] The enrofloxacin succinate prepared in Example 1 and other components were mixed, pulverized and sieved according to the following formula, and the enrofloxacin powder was prepared by the usual method.

[0031] Enrofloxacin Succinate 13.3%

[0032] Sucralose 5%

[0033] Ethyl vanillin 0.5%

[0034] Sodium Chloride 30%

[0035] Anhydrous glucose was added to 100% of the total amount.

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PUM

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Abstract

The invention discloses a medicinal composite preparation containing quinolones, a preparation method thereof and an application thereof. The medicinal composite preparation containing quinolones comprises the following components, by mass, 0.5-95% of a quinolone medicine or a salt compound thereof, 1-97% of an organic acid or a salt compound thereof, 1-98.5% of a sweetener, 0-45% of a flavor enhancer, 0-10% of a flavoring agent, and the balance excipient. Finished products prepared from the medicinal composite preparation containing quinolones, which have the characteristics of stability, excellent dispersibility, good palatability and easy absorption, can be used as a broad-spectrum antiseptic, have the advantages of strong bactericidal activity, wide in vivo distribution and no cross drug resistance with other antibiotic medicines, and are effective to bacteria and mycoplasmas, can be used to treat various infectious diseases of the alimentary system, the respiratory system, the urinary system or the skin soft tissue of animals, wherein the diseases are caused by the sensitive bacterial or the mycoplasmas.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a drug compound preparation containing quinolones and its preparation method and application. Background technique [0002] Quinolones (4-quinolones), also known as pyroxic acids or pyridone acids, are a relatively new class of synthetic antibacterial drugs, usually targeting bacterial DNA, hindering DNA gyrase, and further causing bacterial DNA Irreversible damage, so as to achieve antibacterial effect. There is almost no cross-resistance between these drugs, and they are ideal antibacterial drugs. [0003] There are many deficiencies in traditional quinolone drug preparations and administration methods, such as: inconvenient use, low drug bioavailability and unwillingness of users to accept, etc., which greatly limit the scope of use of quinolone drugs. have brought inconvenience. The Chinese patent application number 92110768.4 discloses a transdermal preparation ...

Claims

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Application Information

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IPC IPC(8): A61K45/08A61K31/496A61K31/5383A61K31/5395A61P31/04
Inventor 王永东操基元
Owner GENIFARM LAB INC
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