Pharmaceutical composition and compound preparation thereof

A compound preparation and composition technology, applied in the field of medicine, can solve problems such as narrow action range, increase heart block, and insignificant effect, and achieve the effects of high compliance, lowering intraocular pressure, and moderate price

Inactive Publication Date: 2012-03-28
ZHAOKE PHARMA HONG KONG COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above five classes of drugs, receptor blockers have ocular and systemic side effects such as bronchospasm, bradycardia, increased heart block, and lower blood pressure; carbonic anhydrase inhibitors also have strong toxic and side effects ; while miotics and adrenaline agonists have a narrow range of action, the effect is not very obvious

Method used

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  • Pharmaceutical composition and compound preparation thereof
  • Pharmaceutical composition and compound preparation thereof
  • Pharmaceutical composition and compound preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of latanoprost and timolol maleate compound preparation

[0029] The medicinal ingredient combination of compound preparation is as shown in table 1, and the pH of this preparation is 6.0, is the content in every liter of solvent:

[0030] Table 1 Prescription of compound preparation

[0031]

Embodiment 2

[0032] Embodiment 2: Preparation of latanoprost and timolol maleate compound preparation

[0033] The composition of the medicinal ingredients of the compound preparation is as shown in Table 2. The pH of the preparation is 5.8, which is the content in every liter of solvent:

[0034] Table 2 Prescription of compound preparation

[0035]

Embodiment 3

[0036] Embodiment 3: Preparation of latanoprost and timolol maleate compound preparation

[0037] The composition of the medicinal ingredients of the compound preparation is as shown in Table 3. The pH of the preparation is 6.2, which is the content in every liter of solvent:

[0038] Table 3 Prescription of compound preparation

[0039]

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PUM

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Abstract

The invention discloses a pharmaceutical composition consisting of latanoprost and timolol maleate, with weight percentages of 0.004-0.007% and 0.6-0.8% respectively. The invention also provides a compound preparation of the pharmaceutical composition, wherein the mass content of the timolol maleate is 0.6-0.8%, and the mass content of the latanoprost is 0.004-0.007%; and auxiliary materials include benzalkonium chloride or RH40 hydrogenated castor oil, sodium chloride, sodium dihydrogen phosphate, disodium hydrogen phosphate and purified water, with the pH of 5.0-6.5. The compound preparation can be used for treating glaucoma with small side effect, so that patient compliance is higher.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition composed of latanoprost and timolol maleate and a compound preparation thereof. Background technique [0002] Glaucoma is a common and difficult eye disease with rapid onset, great harm, and blindness at any time. It ranks second in my country's ophthalmic diseases, accounting for about 14% of ophthalmic diseases, and it is increasing year by year. It is characterized by the intermittent or persistent increase in intraocular pressure that exceeds the tolerance of the eyeball and damages the tissues and visual functions of the eyeball, resulting in atrophy of the optic nerve, narrowing of the field of vision, loss of vision, and even blindness. Complete blindness can occur within 24-48 hours of the acute attack. [0003] At present, the drugs used to treat glaucoma on the market are mainly divided into five categories: prostaglandin drugs, such as latanoprost,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5575A61K31/5377A61P27/06A61P9/12
Inventor 李小羿戴向荣张国辉杨中强
Owner ZHAOKE PHARMA HONG KONG COMPANY
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