Low-molecular-weight polysaccharide sulfate and preparation method and application thereof
A technology of diester sodium alginate and low molecular weight, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve problems such as adverse reactions and weakness, and achieve improved solubility, reduced bleeding side effects, and prolonged Effects of clotting time and bleeding time
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Embodiment 1
[0020] Embodiment 1: the preparation of low molecular weight sodium alginate diester
[0021] Weigh 9 g of sodium alginate diester (weight average molecular weight is about 14 kDa) and dissolve it in 120 mL of distilled water to prepare a 7.5% sodium alginate diester solution. Add 0.1mol·L -1 FeSO 4 solution and 30% H 2 o 2 aqueous solution, so that Fe in the reaction system 2+ and H 2 o 2 concentrations to achieve the specified final concentrations shown in Table 1. The closed shaking reaction was carried out at 60°C for 0.5h. After the reaction, according to 3mg·mL -1 The amount of reaction system Add ascorbic acid to consume H 2 o 2 The reaction was terminated and rapidly cooled, and 3 times the volume of 95% ethanol was added, and left standing overnight at 4°C. Centrifuge at 3000r·min-1 for 20min to separate the precipitate and supernatant. Dissolve the precipitate in a small amount of water, desalt and purify the sample with 732 cation exchange resin, and co...
Embodiment 2
[0029] Embodiment 2: The main pharmacological activity experiment of low molecular weight sodium alginate diester
[0030] The main pharmacological activity experimental results of the low molecular weight sodium alginate diester obtained by applying the method of the present invention are as follows, and the following results are all obtained through systematic experimental research according to the method stipulated by the state.
[0031] A: Anticoagulant activity test of low molecular weight sodium alginate diester
[0032] Insert the capillary tube into the venous plexus behind the inner canthus of the mouse to take blood, and record the time from blood collection to the appearance of coagulation filaments as the index for testing the coagulation time; after the tail of the mouse is docked, record the time from the natural outflow of blood to the natural cessation of blood To test the index of bleeding time. The above two indicators were used to detect and compare the ant...
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