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Filtration apparatus for removing leucocytes from plasmodium-infected blood

A Plasmodium infection and filtration device technology, which is applied in the direction of filtration separation, gravity filter, fixed filter element filter, etc., can solve the problems of low content of Plasmodium malariadin, reduced activity of Plasmodium, cumbersome operation, etc., and achieve filter design Scientific and reasonable, novel filter material, and the effect of improving the recovery rate

Inactive Publication Date: 2012-02-22
陶志勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the filter column prepared by CF11 cellulose powder has a good function of removing white blood cells, the volume of the column bed is relatively large, and the loss of red blood cells after filtration is large, and the infected red blood cells containing mature stage malaria parasites are easily trapped, which intensifies the infection rate of parasites. The loss of experimental samples is cumbersome and time-consuming, which often leads to a decrease in the activity of malaria parasites, and the experimental results are unreliable
The magnetic separation technology is based on the fact that the iron contained in malaria pigment, a metabolite of Plasmodium, can be attracted by magnetic force to achieve the purpose of separation. Separation techniques are not reliable

Method used

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  • Filtration apparatus for removing leucocytes from plasmodium-infected blood
  • Filtration apparatus for removing leucocytes from plasmodium-infected blood
  • Filtration apparatus for removing leucocytes from plasmodium-infected blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Such as Figure 1-3 As shown, the filter device for removing leukocytes in Plasmodium-infected blood includes a filter assembly and a filter element, and the filter assembly includes an upper filter part 1 and a lower filter part 2 with the same shape; the shape of the upper and lower filter parts It is bell-shaped; a filter element 3 is arranged in the middle of the upper and lower filter parts.

[0020] When in use, place the filter element made of non-woven fabric that retains leukocytes in the filter, and screw the upper and lower filter parts to seal it, and the tips of the two filter parts are sleeved on the catheter 4 to prevent malaria parasite infection. The sample suspension prepared by human blood, animal blood or culture can be pushed into the filter by a syringe from the upper pipe of the filter, the cell sample passes through the filter core, the white blood cells are retained, and the infected red blood cells flow out with the liquid, and are collected th...

Embodiment 2

[0022] Such as Figure 1-3 As shown, the filter device for removing leukocytes in Plasmodium-infected blood includes a filter assembly and a filter element, and the filter assembly includes an upper filter part 1 and a lower filter part 2 with the same shape; the shape of the upper and lower filter parts It is bell-shaped; a filter element 3 is arranged in the middle of the upper and lower filter parts.

[0023] When in use, place the filter element made of non-woven fabric that traps white blood cells in the filter, and fix the upper and lower filter parts through locks to make them hermetically sealed. The sample suspension prepared from infected human blood, animal blood or culture can be pushed into the filter by a syringe from the upper conduit of the filter, the cell sample passes through the filter core, the white blood cells are retained, and the infected red blood cells flow out with the liquid, pass through the lower conduit of the filter, and are collected. Collect...

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Abstract

The present invention discloses a filtration apparatus for removing leucocytes from plasmodium-infected blood. The filtration apparatus comprises a filter assembly and a filter core. The filter assembly comprises two filter components of an upper filter component and a lower filter component, wherein the two filter components have the same shapes, which are bellmouth-shaped. The filter core is arranged between the upper filter component and the lower filter component. The filtration apparatus provided by the present invention has the following advantages that: the used filter material is novel; the effect is definite; the filter design is scientific and reasonable; the filter method is practical and convenient; with the apparatus, efficient removal of the leucocytes in the sample can be ensured, the most of the purified plasmodium-infected erythrocytes can be concurrently recovered.

Description

technical field [0001] The invention relates to a filtering device, in particular to a filtering device for removing leukocytes in blood infected by malaria parasites. Background technique [0002] Malaria is a parasitic disease that seriously threatens human health. There are about 250 million cases of the disease every year in the world, and the population threatened by malaria is about 3 billion. The death rate due to falciparum malaria infection is about 800,000 people, mostly children under 5 years old. Plasmodium vivax is more widely distributed around the world and is also the main species in China. [0003] A thorough study of the biology and other properties of Plasmodium is an important basis for the prevention and control of malaria. The establishment of in vitro subculture technology has enabled the research of Plasmodium falciparum to obtain a steady stream of research materials, which has played a major role in the breakthrough of the research on candidate mol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D29/085B01D29/05
CPCY02A50/30
Inventor 陶志勇高琪王辉
Owner 陶志勇
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