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Andrographolidume sustained-release preparation as well as preparation method and use of same

A technology of total andrographolide and sustained-release preparations, which is applied in the field of sustained-release preparations of total andrographolide, which can solve the problems of inability to obtain mechanical parameters of sustained-release preparations of traditional Chinese medicine, increased formulation design of sustained-release excipients, and difficulty in guiding the design of sustained-release preparations of traditional Chinese medicine and other issues, to achieve the effect of improving bioavailability, reducing medical burden, and uniform drug release speed

Inactive Publication Date: 2012-02-08
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the research process of Chinese medicine sustained-release preparations, there are the following obstacles: (1) The active ingredients of traditional Chinese medicine are complex, even if the effective parts are extracted and purified, the components are quite complicated, and the mechanical parameters required for the design of traditional Chinese medicine sustained-release preparations cannot be obtained , it is difficult to guide the design of traditional Chinese medicine sustained-release preparations theoretically; (2) most traditional Chinese medicines or effective parts have relatively complex physical and chemical properties, which also increases difficulties in the screening of sustained-release excipients and the design of preparation prescriptions. Difficulties in molding process (Huang Yuan, et al., Research Progress and Existing Problems of Traditional Chinese Medicine Sustained-release Preparations, Chinese Journal of Pharmaceutical Sciences, Vol. 25, No. 4, 2009.)

Method used

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  • Andrographolidume sustained-release preparation as well as preparation method and use of same
  • Andrographolidume sustained-release preparation as well as preparation method and use of same
  • Andrographolidume sustained-release preparation as well as preparation method and use of same

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Effect test

Embodiment 1

[0032] The preparation of embodiment 1 total andrographolide sustained-release preparation of the present invention

[0033] Weigh andrographolide 80g, HPMC K15M 60g, lactose 111g, starch 37g, PVP9g, andrographolide, HPMC K15M, lactose, starch, PVP were passed through 80 mesh sieve respectively, and andrographolide and auxiliary materials were pressed Mix evenly by incremental method, add appropriate amount of binder to make soft material, make granules, dry at 60°C for 1 hour, sieve No. 2 sieve, add 1% lubricant magnesium stearate based on the weight of the granules, and control the pressure at 7-9kg .cm -1 Instantly. Each tablet of this product contains about 80mg of total andrographolide, and the weight of the tablet is about 300mg.

[0034] Wherein, the total andrographolide used is the extract of the dry aerial part of Andrographis paniculata (Burm.f.) Nees, a plant of the genus Andrographis of the family Acanthaceae, and the total andrographolide contained in the extra...

Embodiment 2

[0035] The preparation of embodiment 2 total andrographolide slow-release preparations of the present invention

[0036] Get total andrographolide 78g, HPMC K15M 60g, lactose 112.5g, starch 37.5g, PVP9g, after total andrographolide, HPMC K15M, lactose, starch, PVP are passed through 80 mesh sieves respectively, total andrographolide and auxiliary material are pressed Mix evenly by equal amount incremental method, add an appropriate amount of binder to make soft material, make granules, dry at 60°C for 1 hour, sieve No. 2 sieve, add 1% lubricant magnesium stearate based on the weight of the granules, and control the pressure at 7- 9kg.cm -1 Instantly. Each tablet of this product contains about 80mg of total andrographolide, and the weight of the tablet is about 300mg.

[0037] Wherein, the total andrographolide refers to the total lactone extract prepared from the Andrographis paniculata (Burm.f.) Nees, a plant of the genus Andrographis paniculata (Burm. Andrographolin, not ...

Embodiment 3

[0038] The preparation of embodiment 3 total andrographolide sustained-release preparations of the present invention

[0039] Get total andrographolide 81g, HPMC K15M 60g, lactose 110.25g, starch 36.75g, PVP9g, after total andrographolide, HPMC K15M, lactose, starch, PVP are passed through 80 mesh sieves respectively, total andrographolide and auxiliary material are pressed Mix evenly by equal amount incremental method, add an appropriate amount of binder to make soft material, make granules, dry at 60°C for 1 hour, sieve No. 2 sieve, add 1% lubricant magnesium stearate based on the weight of the granules, and control the pressure at 7- 9kg.cm-1 Instantly. Each tablet of this product contains about 80mg of total andrographolide, and the weight of the tablet is about 300mg.

[0040] Wherein, the total andrographolide used is extracted according to the method described in CN200910115426.0.

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Abstract

The invention discloses an adrographolidume sustained-release preparation as well as preparation method and use of the same. Categories and dosages of auxiliary materials are screened to prepare the adrographolidume sustained-release preparation; and the preparation can be released at a uniform releasing velocity by about 30%, 60%, 80% and above 90% in 3h, 6h, 10h and 12h respectively, and can becompletely released within predetermined 12 hours. When the adrographolidume sustained-release preparation is adopted, bioavailability of medicine is improved, toxic side effects of adrographolidume on human body is effectively reduced, and the utilization rate of the medicine is ensured as the medicine of the sustained-release preparation is completely released.

Description

technical field [0001] The invention relates to a sustained-release preparation of total andrographis paniculata lactone, a preparation method and application of the preparation, and belongs to the field of medicines. Background technique [0002] Andrographis paniculata (Burm.f.) Nees is the dry aboveground part of Andrographis paniculata (Burm.f.) Nees. Andrographis paniculata has various pharmacological activities such as antibacterial, anti-inflammatory, anticancer, and treatment of cardiovascular diseases. Andrographis paniculata is widely used, has fast absorption in animals, long drug effect, high bioavailability, and has great clinical application value. [0003] The main active ingredients of andrographolide are flavonoids and andrographolide (Andrographolide), neoandrographolide (Neoandrographolide), dehydroandrographolide (dehydroandrographolid), 14-deoxyandrographolide (DA) and 14-deoxy-11,12 -Didehydroandrographolide (DDA), etc., lactones are collectively refer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K9/22A61K47/38A61P9/00
Inventor 李小芳尹帮龙舒予刘玲
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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