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Traditional Chinese medicine composition for treating functional dyspepsia

An indigestion and functional technology, applied in the field of medicine, can solve problems such as side effects, and achieve the effects of small side effects, convenient use and portability, and rapid onset of effects.

Active Publication Date: 2012-01-25
SHENZHEN HUIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above deficiencies in the prior art, the purpose of the present invention is to provide a Chinese medicine for the treatment of functional dyspepsia, aiming to solve the problem of side effects of existing drugs for the treatment of functional dyspepsia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] The Chinese medicine composition for treating functional dyspepsia is made into granules, and the specific steps of its preparation method are as follows:

[0033] S100, preparation of medicinal material extract:

[0034] S101. Place the medicinal materials of the prescribed amount in the extraction tank, add 8 times the amount of normal water (w / v), heat and reflux for 3 hours, filter, collect the filtrate, keep the medicinal residues, and then add 6 times the amount of water to the extraction tank ( w / v), heating to reflux for 2h, filtering, collecting the filtrate, and combining two batches of filtrate.

[0035] S102. Put the filtrate into a concentration tank, keep the temperature at 70-80°C, and concentrate under reduced pressure (vacuum degree 0.096MPa) until the relative density reaches 1.03-1.05 (75°C).

[0036] S103. With stirring, add 95% ethanol to the concentrated medicinal solution until the ethanol content is 65%, put it into a cold storage, keep it at 4°...

Embodiment 1

[0048] The consumption of each taste medicine raw material is as follows:

[0049] Scutellaria baicalensis 17kg Coptidis 17kg Phellodendron 17kg

[0050] Gardenia 17kg Radix Paeoniae Rubra 17kg Angelica 5kg

[0051] Chuanxiong 5kg Rehmannia glutinosa 5kg

[0052] A. The preparation method of medicinal material extract is as follows:

[0053] A1. Place the medicinal materials of the prescribed amount in a 1000L extraction tank, add 8 times the amount of normal water (w / v) (800L), heat and reflux for 3h, filter, collect the filtrate, keep the medicinal residues, and then add 6 Double the amount of water (w / v) (600L), heat to reflux for 2h, filter, collect the filtrate, and combine the two batches of filtrate;

[0054] A2. Put the filtrate into a 2000L concentration tank, keep the temperature at 70-80°C, and concentrate under reduced pressure (vacuum degree 0.096MPa) until the relative density reaches 1.25 (75°C);

[0055]A3. Under stirring, add 95% ethanol to the concentrate...

Embodiment 2

[0074] Experiments on Promoting Gastric Motility

[0075] experimental animals

[0076] Male Wistar rats, weighing 200±10 g, were purchased from the Experimental Animal Center of Sun Yat-sen University School of Medicine. Animal room temperature: 24±2°C; humidity 60±5%, light time 12 hours, fasting without food and water for 12 hours before the experiment.

[0077] experimental drug

[0078] Test drug: the granules in Example 1 are dissolved with deionized water, filtered, and the filtrate is prepared with deionized water into a 20mg crude drug / ml solution of the test product, stored at 4°C for subsequent use;

[0079] Positive control drug: cisapride suspension (Xi’an Janssen Pharmaceutical Co., Ltd., batch number AC1012002), made into a 5 × 10-2mg / ml solution with deionized water, stored at 4°C for future use;

[0080] Blank control: deionized water

[0081] Gastrointestinal markers: Dextran Blue-2000 (produced by Pharmacia), made into a 2% solution with deionized water....

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating functional dyspepsia, which is prepared from the following components in parts by weight: 15-19 parts of Baikal skullcap root, 15-19 parts of coptis, 15-19 parts of phellodendron bark, 15-19 parts of gardenia, 15-19 parts of red paeonia, 4-6 parts of angelica, 4-6 parts of hemlock parsley and 4-6 parts of radix rehmanniae. The traditional Chinese medicine composition is made into granules according to conventional pharmaceutical product technology. The granules have the function of relieving or eliminating the symptoms of functional dyspepsia, have the advantages of small side effect and quick effect taking, and are convenient to use and carry.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating functional dyspepsia. Background technique [0002] Fullness syndrome (functional dyspepsia) is a common disease and frequently-occurring disease in the internal medicine digestive system. In traditional Chinese medicine, it often manifests as stagnation of liver and stomach heat, stagnation of liver and stomach qi, and stomach loss and crimson, often caused by dysmotility of the digestive tract. The scope of the disease involves a large base of patients, and there is no obvious regional or temporal difference in the incidence rate in various places. Simultaneously in people's life, most people have experienced symptoms such as stomach and wrist fullness and pain similar to this disease. In recent years, due to various reasons such as the accelerated pace of life, the influence of mental and emotional factors, and changes in eating...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P1/14
Inventor 孔翔欧荔枝孔徐生刘洋李冬丁国华雷江凌
Owner SHENZHEN HUIMIN PHARMA
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