Synthesis method of middle-molecular-weight hydroxyethyl starch

Abstract

The invention provides a synthesis method of middle-molecular-weight hydroxyethyl starch. The synthesis method comprises the following steps: carrying out hydroxyethyl substitution reaction on waxy corn starch hydrolyzate and a hydroxyethyl substituting agent under the conditions that water is used as a solvent and sodium hydroxide is taken as a catalyst; and carrying out ultrafiltration interception membrane separation and activated carbon decoloration, filtering, and carrying out spray drying on filtrate so as to obtain the white powdery middle-molecular-weight hydroxyethyl starch product. According to the invention, an adopted aqueous phase synthesis method has the advantages that an ideal molar degree of substitution (MS) of hydroxyethyl and an ideal substitution position ratio (C2:C6) are conveniently controlled in the reaction, and the byproducts of the reaction are easy to separate; and under the condition of the aqueous phase synthesis method, the reaction is a room temperature reaction, reactants and the catalyst are completely dissolved in the reaction system, the substitution positions are uniformly distributed in the product, the reaction byproducts such as sodium chloride, chlorohydrin, cyclochloroethane, glycol and the like can be easily removed once through a membrane separation technology, the obtained product has proper MS and a ratio of C2:C6, and the obtained product quality can reach or be superior to the existing national drug standard.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and relates to a production method of medium molecular weight hydroxyethyl starch, in particular to a synthesis method of hydroxyethyl starch 200 / 0.5 and hydroxyethyl starch 130 / 04. Background technique [0002] The main physiological functions of plasma volume expanders are to maintain normal plasma colloid osmotic pressure and expand plasma volume, improve hemodynamics, microcirculatory blood flow, hemorheology, oxygen supply and organ function. It is used for the treatment of shock caused by massive bleeding, burns or other trauma. An ideal plasma volume expander, which can quickly replenish lost blood volume, restore hemodynamic balance, restore normal microcirculatory blood flow, improve blood rheology, improve oxygen supply and organ function, and have a long enough residence time in blood vessels And good tolerance, and easy to be metabolized and excreted in the body. [000...

AI Technical Summary

Problems solved by technology

[0011] The hydroxyethyl reaction can usually be produced at the C2, C6, and C3 positions of the glucose unit in starch, and the reactivity decreases sequentially. The pharmacological properties of products substituted at different positions are not the same. Studies have shown that the relative increase in the substitution of the C2 position will lead to Prolonged catabolism of hydroxyethyl starch in vivo

Images