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Anticoccidiosis compound and preparation method as well as application thereof

A compound, anti-coccidial technology, applied in the application, animal feed, organic chemistry and other directions, can solve the problem of parasite drug resistance, and achieve the effects of low cost, simple process operation and high yield

Inactive Publication Date: 2012-01-11
CHINA ANIMAL HUSBANDRY IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-term use of these drugs will easily lead to drug resistance of parasites, so there is an urgent need for new drugs to appear. With the development of animal husbandry, aquaculture and public health security, the market demand for new anti-parasitic drugs will increase , while infectious diseases caused by some viruses and bacteria are occurring around the world, parasitic diseases will be the next problem that must be paid attention to and solved

Method used

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  • Anticoccidiosis compound and preparation method as well as application thereof
  • Anticoccidiosis compound and preparation method as well as application thereof
  • Anticoccidiosis compound and preparation method as well as application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The first step: Synthesis of N-benzyloxycarbonyl-4-piperidinecarboxylic acid

[0026]

[0027] In the 1L three-necked flask of the 1000mL three-necked flask device thermometer and the addition funnel, add 200mL water, then add 4-piperidinecarboxylic acid (30g, 0.232mol), then slowly add NaOH (27.9g, 0.697mol), after reacting for 30 minutes, Then CbzCl (79.1 g, 0.464 mol) was added dropwise to react overnight at room temperature.

[0028] Post-processing:

[0029] Add 300mL saturated ammonium chloride aqueous solution to the reaction solution, extract twice with ethyl acetate (300mL×2), adjust the aqueous phase to acidity with HCL, then extract twice with ethyl acetate (300mL×2), and dry the organic phase , and evaporated to dryness to obtain 53 g of the product with a yield of 86.8%.

[0030] 1 HNMR (CDCl 3 ): 10.2 (br, 1H), 7.4 (m, 5H), 5.17 (s, 2H), 4.1 (m, 2H), 2.85 (m, 2H), 1.6-1.7 (m, 4H).

[0031] The second step: synthesis of N-benzyloxycarbonyl-4-(N-meth...

experiment example 1

[0097] Experimental Example 1 The drug efficacy test of compound of the present invention preventing coccidiosis of artificially infected broilers

[0098] 1. Test materials

[0099] 1. Test drug and dose: Compound A obtained in Example 1, 50 ppm.

[0100] 2. Animals: 10 freshly hatched AA broilers, free to drink water and eat food, the test period is 1-10 days old.

[0101] 3. Feed: full price feed for broilers. The feed did not contain any other anticoccidial drugs or antibacterial drugs except for the drugs to be added in the test.

[0102] 4. Coccidia strain: Eimeria tenella Beijing strain, purchased from the Parasitology Teaching and Research Group of the School of Veterinary Medicine, China Agricultural University.

[0103] 5. Reagents and equipment: conventional reagents and equipment used for cultivating and counting coccidia.

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Abstract

The invention relates to an anticoccidiosis compound, which is shown as the following structural formula (I), and also relates to a preparation method of the anticoccidiosis compound. Through the anticoccidiosis compound, the problem of drug resistance of the conventional anticoccidiosis medicine can be effectively solved, and an important role is played in treatment of domestic animals, particularly chicken coccidiosis infection. A main raw material used in the invention is extremely readily available on market and is cheap; and the compound has the characteristics of simple process operation, no danger, low cost, high yield and the like, is suitable for amplification and industrial production and has industrial value.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to the prevention and treatment of livestock and poultry parasites, and more specifically relates to an anticoccidial compound and its preparation method and application. Background technique [0002] Coccidiosis is one of the main causes of disease and death in poultry and poultry. Failure to effectively control coccidiosis will bring huge losses to the livestock and poultry breeding industry. Since the 1980s, livestock and poultry have gradually developed great resistance to the existing anticoccidial drugs, and the demand for new low-priced broad-spectrum drugs has become very urgent. [0003] Coccidiosis is a parasitic disease that can cause severe losses in poultry meat and egg production. Multiplication of parasites in the small intestine results in hampered damage, reduced feed intake and absorption of nutrients from feed, dehydration and blood loss. After chickens ingest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/14A61K31/4545A61P33/02A23K1/16A23K20/121A23K50/50A23K50/75
Inventor 刘金华潘强李新乐郭以猛马佳颖王峥
Owner CHINA ANIMAL HUSBANDRY IND
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