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An electrochemical method for the simultaneous determination of rutin and quercetin based on a graphene-modified electrode

A technology for modifying electrodes and graphene, applied in the field of electrochemical analysis, can solve problems such as overlapping, and achieve the effects of good selectivity, low overpotential, and simple preparation process

Active Publication Date: 2011-12-21
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the similar oxidation potentials of rutin and quercetin on conventional glassy carbon electrodes, the oxidation peaks of rutin and quercetin overlap, which limits its application in the simultaneous determination of rutin and quercetin

Method used

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  • An electrochemical method for the simultaneous determination of rutin and quercetin based on a graphene-modified electrode
  • An electrochemical method for the simultaneous determination of rutin and quercetin based on a graphene-modified electrode
  • An electrochemical method for the simultaneous determination of rutin and quercetin based on a graphene-modified electrode

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Experimental program
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Embodiment 1

[0027] Weigh 2.5g of natural flakes with a particle size of 200 mesh, slowly add it to a beaker containing 57.5mL of concentrated sulfuric acid, stir and continue to slowly add 1.25g of sodium nitrate and 7.5g of potassium permanganate to the beaker under ice bath conditions The formed mixture was then reacted in an ice bath for 2 hours, then placed in a water bath at 32°C to 38°C, and kept warm for 30 minutes. Maintain the temperature for 15 minutes, then add warm water at 40°C to the beaker to dilute until the volume of the solution in the beaker reaches 350mL, stop adding warm water, and then add 5% H2O to the beaker 2 o 2 , filtered while hot until there was no SO in the filtrate 4 2- (with BaCl 2 Solution detection), collect the filter residue, and put the filter residue at 50°C in P 2 o 5 Dry in the presence of 24h to obtain graphite oxide, which is sealed and stored for later use.

[0028] Weigh 100mg of the above-mentioned graphite oxide into a round bottom flask...

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Abstract

The invention discloses an electrochemical method based on a graphene-modified electrode for simultaneous determination of rutin and quercetin. The graphene-modified electrode is used as a working electrode, and cyclic voltammetry and differential pulse voltammetry are adopted for simultaneous determination of the rutin and the quercetin. Since grapheme is used as a modifying material for the electrode, electrochemical separation of two Chinese flavonoids, the rutin and the quercetin can be achieved on the modified electrode, and the contents of the rutin and the quercetin in sophora flower bud can be determined simultaneously through direct electrochemical determination.

Description

technical field [0001] The invention relates to the determination of traditional Chinese medicine flavonoids, in particular to an electrochemical method capable of simultaneously measuring rutin and quercetin, and to a preparation method of the graphene-modified glassy carbon electrode, which belongs to the technical field of electrochemical analysis. Background technique [0002] Flavonoids rutin and quercetin are widely found in the plant kingdom and the daily diet of humans. They participate in the construction of capillary walls and can reduce the permeability and fragility of blood vessels. They are becoming more and more widespread Ground is used as a multifunctional substance such as anti-cancer and anti-oxidation. At present, rutin has been used as a drug in clinical treatment. As the sugar base of rutin, quercetin often coexists with rutin. If certain rutin-containing tablets and softgels are not stored properly, quercetin may be present in the hydrolyzate of ruti...

Claims

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Application Information

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IPC IPC(8): G01N27/48G01N27/30C01B31/04
Inventor 王宗花赵凯迟德玲张菲菲夏建飞朱玲艳
Owner QINGDAO UNIV
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