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Composite cyclodextrin clathrate of licorice flavones and ferulic acid and preparation method and applications thereof

A technology of licorice flavonoids and cyclodextrin, applied in the field of beauty, can solve problems such as poor solubility, and achieve the effects of increasing stability, removing stains, and repairing damaged skin

Active Publication Date: 2013-04-24
GUANGDONG SOUTHERN JIELING TECH IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the above problems, the object of the present invention is to provide a cyclodextrin complex inclusion compound of licorice flavonoids and ferulic acid, which can solve the problem of poor solubility of the two, increase the stability of ferulic acid, and make the active ingredients It can be released for a long time, and at the same time, the appearance of the finished product is more comfortable, and the skin whitening effect is more balanced after use

Method used

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  • Composite cyclodextrin clathrate of licorice flavones and ferulic acid and preparation method and applications thereof
  • Composite cyclodextrin clathrate of licorice flavones and ferulic acid and preparation method and applications thereof
  • Composite cyclodextrin clathrate of licorice flavones and ferulic acid and preparation method and applications thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0025] The preparation method of the above-mentioned complex clathrate comprises the following steps: add an appropriate amount of water to the cyclodextrin, preferably cyclodextrin: water = 1.2 ~ 1.4g: 1; then put it in a colloid mill and grind it evenly; add licorice flavone and The ethanol solution of ferulic acid, the preferred solution concentration is 1.0~1.25g / mL), continue to grind to paste; dry, preferably blow dry, the temperature is between 40~60 ℃, 3~5 hours to meet the product requirements, Smash it at the end.

[0026] The above-mentioned complex clathrate is applied to the preparation of cosmetics, and the cosmetic formulations include, for example, creams, gels and the like.

Embodiment 1

[0027] Example 1: Licorice flavonoids and ferulic acid complex HP-β-CD inclusion compound 1

[0028] Formula: Licorice flavonoids 20g, ferulic acid 10g, HP-β-CD 80g, distilled water 60mL, ethanol 25mL.

[0029] Preparation method: Add HP-β-CD to distilled water, mix evenly, put it in a colloid mill, grind it evenly, add the ethanol solution of licorice flavonoids and ferulic acid under the grinding state, continue grinding for 4 hours, until it becomes a paste, at 50 ° C, blast Dry for 3 hours and crush to obtain the clathrate.

Embodiment 2

[0030] Example 2: Licorice flavonoids and ferulic acid complex HP-β-CD inclusion compound 2

[0031] Formula: licorice flavonoids 30g, ferulic acid 20g, HP-β-CD 100g, distilled water 80mL, ethanol 40mL.

[0032] Preparation method: with embodiment 1.

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Abstract

The invention discloses a composite cyclodextrin clathrate of licorice flavonoids and ferulic acid and a preparation method and applications thereof. The composite cyclodextrin clathrate comprises the following components in parts by weight: licorice flavonoids 10-30 parts, ferulic acid 5-20 parts, and cyclodextrin 60-100 parts. The preparation method comprises the following steps: adding water to cyclodextrin, grinding, adding ethanol solution of licorice flavonoids and ferulic acid, grinding to paste, drying, and pulverizing. The composite cyclodextrin clathrate can be used in preparing cosmetics. The composite cyclodextrin clathrate has the synergetic pharmacological action of both licorice flavonoids and ferulic acid; the addition cyclodextrin to prepare the clathrate can solve the poor dissolution problem of licorice flavonoids and ferulic acid; the stability of ferulic acid is improved, and the effective ingredients can be released in a sustained manner; and the appearance of finished products is more comfort. After use, the skin whitening effect is more uniform. The composite cyclodextrin clathrate can be used in cosmetics for whitening skin, preventing and treating skin inflammations and repairing damaged skin, and the whitening effect is more sustained.

Description

technical field [0001] The invention relates to the cosmetic field, in particular to a cyclodextrin complex inclusion compound of licorice flavonoids and ferulic acid, a preparation method and application thereof. Background technique [0002] There are many kinds of skin problems. Among them, skin pigmentation is a common multiple skin disease that causes skin spots to appear due to the deposition of melanin in the skin. The external causes of skin pigmentation are mostly dry skin, aging, acne scars, sun exposure, caused by ultraviolet radiation. Skin aging is a phenomenon of skin aging, which is mainly manifested in the deterioration of skin elasticity, thinning, wrinkles and pigment spots. [0003] Licorice flavonoids are a class of flavonoids extracted from licorice, including flavonoids, isoflavones, chalcones, dihydroflavonoids, etc., which have liver protection, anti-free radical, anti-tumor, anti-inflammatory and anti-allergic reactions , anti-pathogenic microorgan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61Q19/00A61K8/365
Inventor 刘莉张璐刘强魏鉴宜
Owner GUANGDONG SOUTHERN JIELING TECH IND
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