Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A drug carrier for slow-release medicine

A drug, carrier technology

Inactive Publication Date: 2011-11-30
钟术光
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the amount of the above-mentioned water-soluble surfactant is slightly higher, it is more likely to cause sudden drug release or dose-dumping (dose-dumping). Incomplete medicine, especially in the middle and late stages

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A drug carrier for slow-release medicine
  • A drug carrier for slow-release medicine
  • A drug carrier for slow-release medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] The following is a detailed description of the above-mentioned drug carrier.

[0031] The matrix of the drug carrier and the material for controlling the release of the drug involved in the present invention are pharmaceutically acceptable aliphatic additives with a melting point higher than 37°C and a melting point higher than 37°C when in contact with body fluids in the body cavity, preferably Aliphatic additives with a melting point of 40°C to 90°C, more preferably 40°C to 70°C, more preferably 40°C to 50°C, the aliphatic additives include but are not limited to melting point Animal and vegetable oils, semi-synthetic oils, fatty acid glycerides, waxes, higher fatty acids, higher fatty alcohols, higher fatty acid esters, higher Aliphatic hydrocarbons and their mixtures.

[0032]Among them, fatty acid glycerides whose melting point is higher than the temperature of 37°C and whose melting point is also higher than the temperature of 37°C when in contact with body fluid...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Viscosityaaaaaaaaaa
Temperatureaaaaaaaaaa
Login to View More

Abstract

The invention discloses a slow-release drug carrier with improved performance. The drug carrier contains (a) an aliphatic additive in vivo-in vitro fusing points of which is higher than 37 DEG C, (b) low-viscosity water-soluble nonirritant additive particles, (c) a water-swelling and water-insoluble acidic (or alkaline) polymer, (d) an alkaline (or acidic) surfactant, and (e) a medicament. The drug carrier has the advantages of better drug release character, higher 'salt poisoning' resistance effect, lower mucosal irritation, better biocompatibility and better drug release uniformity, thus better relieving or solving 'terminal release' problem and avoiding medication safety problems such as burst drug release or dose dumping and the like.

Description

technical field [0001] The invention relates to a medicine carrier for sustained release of medicine. More specifically, the present invention relates to a drug carrier for sustained-release drug with improved properties, the drug carrier includes aliphatic additives with in vivo and in vitro melting points greater than 37°C, water-soluble low-viscosity additive particles, water Swellable water-insoluble acidic (or basic) polymers, basic (or acidic) surfactants and drugs. technical background [0002] Sustained-release preparations such as sustained-release suppositories, especially those with oily materials as the main sustained-release material, often exhibit the so-called "terminal release" problem, that is, the release of the drug is fast in the early stage, gradually slows down in the middle stage, and slows down in the later stage. Often, a part of the drug remains in the matrix within the specified (or expected) action time, and cannot play the expected role, or it i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K47/32A61K47/34A61K47/36A61K47/38A61K9/02
Inventor 钟术光
Owner 钟术光
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com