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A formula and preparation method of Xiaoer Chaigui Tuire Granules

An antipyretic and pediatric technology, applied in the field of Xiaoer Chaigui Antipyretic Granules and its preparation, can solve the problems of easy to infect bacteria, poor taste, inconvenient taking, etc., achieve the effect of small dosage, sweet taste, and solve the difficulty of medication

Active Publication Date: 2011-11-30
葵花药业集团(襄阳)隆中有限公司
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AI Technical Summary

Problems solved by technology

[0004]The existing children's Chaigui antipyretic oral liquid has the disadvantages of poor taste, easy to infect bacteria, and inconvenient to take in low temperature seasons

Method used

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  • A formula and preparation method of Xiaoer Chaigui Tuire Granules
  • A formula and preparation method of Xiaoer Chaigui Tuire Granules
  • A formula and preparation method of Xiaoer Chaigui Tuire Granules

Examples

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Effect test

Embodiment 1

[0091] Take 260g of Bupleurum, 90g of Guizhi, 140g of Pueraria radix, 120g of Scutellaria baicalensis, 120g of honeysuckle, 180g of Radix Radix, 90g of cicada slough and seven flavors of traditional Chinese medicine, take Guizhi, Bupleurum, and gold and silver and grind them into 10-20 mesh coarse particles, add 12 times the amount of water, Heat to 80°C, soak for 1 hour, distill for 4 hours, add 10% sodium chloride to the distillate, refrigerate for 12 hours, separate the upper layer oil, add 4 times the amount of beta-cyclodextrin, 8 times the amount of water, Grind in a colloid mill for 20-30 minutes, take out the paste, dry it in an oven at 50°C, crush it and pass it through a 60-mesh sieve for later use; filter the distilled water, add 6 times the amount of water to decoct the dregs for 0.5 hours , filtered, and the filtrate was combined with the distilled water for later use. Get Radix Puerariae, be ground into the coarsest powder, according to the percolation method (an...

Embodiment 2

[0093] Take 200g of Bupleurum, 70g of Guizhi, 200g of Pueraria radix, 100g of Scutellaria baicalensis, 100g of honeysuckle, 100g of honeysuckle, and 70g of cicada slough. Take cinnamon, bupleurum, and honeysuckle and crush them into 10-20 mesh coarse particles, add 10 times the amount of water, and heat to 80°C, soak for 1.5 hours, then distill for 4.5 hours, add 10% sodium chloride to the distillate, refrigerate for 10 hours, separate the upper layer oil, add 4.5 times the amount of beta-cyclodextrin, 9 times the amount of water, put Grind in a colloid mill for 30 minutes, take out the paste, dry it in an oven at 50°C, crush it and pass it through a 60-mesh sieve for later use; filter the distilled water, add 5 times the amount of water to decoct the dregs for 0.5 hours, and filter , the filtrate was combined with the distilled water, and set aside. Get Radix Puerariae, be ground into the coarsest powder, according to the percolation method (an appendix 10 of Chinese Pharmaco...

Embodiment 3

[0095] Take 300g of bupleurum, 110g of cinnamon twigs, 300g of kudzu root, 150g of honeysuckle, 150g of baicalin, 300g of isatidis, and 110 cicadas. Crush cinnamon, bupleurum, and honeysuckle into 10-20 mesh coarse particles, add 14 times the amount of water, and heat to 80°C, soak for 1.5 hours, then distill for 5 hours, add 10% sodium chloride to the distillate, refrigerate for 10 hours, separate the upper layer oil, add 4.5 times the amount of beta-cyclodextrin, 10 times the amount of water, put Grind in a colloid mill for 30 minutes, take out the paste, dry it in an oven at 50°C, crush it and pass it through a 60-mesh sieve for later use; filter the distilled water, add 6 times the amount of water to decoct the dregs for 0.5 hours, and filter , the filtrate was combined with the distilled water, and set aside. Get Radix Puerariae, be ground into the coarsest powder, according to the percolation method (an appendix 10 of Chinese Pharmacopoeia version in 2005) under the extr...

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Abstract

The invention discloses a formula of children' s antipyretic granule by using radix bupleuri and cassia twig, and its preparation method, and belongs to the technical field of traditional Chinese medicine. The invention mainly solves the problems of bad mouth feel, easily bacterial infection and inconvenient taking in low temperature season of the present oral liquid. The children' s antipyretic granule comprises the following bulk drugs in the granular: 200-300 parts of radix bupleuri; 70-110 parts of cassia twig, 200-300 parts of kudzuvine root; 100-150 parts of radix scutellariae, 100-150 parts of honeysuckle flower, 100-300 parts of isatis root and 70-110 parts of periostracum cicadae. The method comprises the following steps: crushing cassia twig, radix bupleuri and honeysuckle flower, distilling, salting out, refrigerating and respectively taking essential oil, adding beta-cyclodextrins; extracting kudzuvine root by an ethanol percolation method to obtain a flavonoid component; performing processes of water extraction, acid precipitation and alcohol precipitation to radix scutellariae to obtain high content scutelloside; decocting the other medicinal materials and concentrating to produce a thin paste; mixing each extract and concentrating to a thick paste, adding a proper amount of cane sugar, beta- cyclodextrins clathrate and a proper amount of dextrin to obtain the granule. The invention has the functions of sweating and relieving exterior syndrome as well as clearing heat and detoxifying, and has the advantages of good mouth feel, less loss of effective ingredients, stable quality, safe auxiliary materials and convenient administration, the children' s antipyretic granule by using radix bupleuri and cassia twig is mainly used for treating children's exogenousfever illness.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine. The invention relates to an oral traditional Chinese medicine granule for exogenous fever and a production method thereof, in particular to a Xiaoer Chai Gui antipyretic granule and a preparation method thereof. Background technique [0002] Exogenous fever is mainly cold fever, that is, fever caused by acute upper respiratory tract infection in Western medicine. It can occur in children of any age, and the younger the age, the higher the incidence rate. For children under 5 years old, the incidence of colds accounts for half of the diseases in this age group, and for children aged 5 to 12, the incidence of colds accounts for 30% of the diseases in this age group. Fever is the most common clinical symptom in children. Because of its physiological and pathological characteristics, children with exogenous fevers are mostly high fevers, which can easily lead to convulsions, de...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K9/16A61P29/00A61P11/00A61P31/00A61K35/64
Inventor 黄正军肖作武何德苟
Owner 葵花药业集团(襄阳)隆中有限公司
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