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Use of ag490 in prevention and treatment of abdominal aortic aneurysm

An abdominal aortic aneurysm, cyano-based technology, applied in the field of medicine, can solve problems such as failure to prevent and contain abdominal aortic aneurysm

Inactive Publication Date: 2011-11-30
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-benzyl-2-acrylamide (AG490 for short) is a synthetic ester of benzylidene malononitrile There is no record in the prior art that AG490 can prevent and curb abdominal aortic aneurysm

Method used

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  • Use of ag490 in prevention and treatment of abdominal aortic aneurysm
  • Use of ag490 in prevention and treatment of abdominal aortic aneurysm
  • Use of ag490 in prevention and treatment of abdominal aortic aneurysm

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Experimental program
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Effect test

Embodiment Construction

[0050] 1. Experimental animals and main reagents

[0051] Experimental animals:

[0052] SPF grade C57BL / 6 mice (male, 6-8 weeks old, 16-18 g) were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal certificate number SCXK (Beijing) 2008-0003. C57BL / 6 mice were bred in the Experimental Animal Center of the Institute of Materia Medica, Chinese Academy of Medical Sciences, with constant temperature and humidity, and free access to food and drink. All animal experiments were approved by the Animal Management Association of the Institute of Materia Medica, Chinese Academy of Medical Sciences.

[0053] Main reagents:

[0054] CaCl 2 was purchased from J.T. Baker Inc. (Phillipsburg, NJ, USA), and AG490 was purchased from Sigma-Aldrich (St. Louis, Missouri, USA). Anti-mouse MMP-2 / 9 was purchased from Santa Cruz Biotechnology (CA, USA). ECL and ECL plus western blotting detection reagents were purchased from Amersham Biosciences Inc. (Piscataway...

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Abstract

The invention discloses (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-benzyl-2-acrylamide (AG490 for short) of the following formula in the prevention and treatment of abdominal aortic aneurysm the use of. In the CaCl2-induced abdominal aortic aneurysm model, AG490 can not only prevent the occurrence of abdominal aortic aneurysm, but also prevent the progressive development of abdominal aortic aneurysm; AG490 can significantly inhibit the expression and activity of matrix metalloproteinases, and alleviate the effect of this proteolytic enzyme on the abdominal aortic aneurysm model. The destruction and degradation of vascular tissue maintains the relative integrity of vascular structure; AG490 can reduce the expression of vascular α-smooth muscle actin (α-SMA) and reduce the deposition of vascular adventitial collagen.

Description

technical field [0001] The purpose of the present invention is to provide a new application of AG490 in the prevention and treatment of abdominal aortic aneurysm, which belongs to the technical field of medicine. Background technique [0002] AAA (Abdominal Aortic Aneurysm, AAA) is a chronic inflammatory disease of the aorta caused by various factors. Abdominal aortic aneurysm occurs mostly in men over the age of 65 and is a common, serious and life-threatening vascular disease. Due to the degradation of elastic fibers in the aortic media and the increased pressure load on the arterial wall, local or general continuous dilation of the aorta may be caused, which may eventually lead to fatal aortic rupture. Therefore, abdominal aortic aneurysm has a high mortality rate and residual rate. [0003] The incidence of abdominal aortic aneurysm is high in western countries. According to statistics, in the United States, 40,000 patients with abdominal aortic aneurysm need surgical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/277A61P35/00
Inventor 胡卓伟闫慧敏崔冰马永刚
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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