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Stigmaster-8(14)22,-diene-7alpha-methoxy-3beta-ol in cucumber roots and use thereof

A methoxy, cucumber technology, applied in the field of stigma-8, can solve the problems that have not been reported in the literature, and achieve the effect of clear material basis, easy to accept, and conducive to exporting foreign exchange.

Inactive Publication Date: 2012-11-07
湖南本草制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching, there is no literature report on this aspect

Method used

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  • Stigmaster-8(14)22,-diene-7alpha-methoxy-3beta-ol in cucumber roots and use thereof
  • Stigmaster-8(14)22,-diene-7alpha-methoxy-3beta-ol in cucumber roots and use thereof
  • Stigmaster-8(14)22,-diene-7alpha-methoxy-3beta-ol in cucumber roots and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Get 200kg of cucumber roots, add 90% ethanol to reflux and extract twice, each time for 1 hour, add 1000kg90% ethanol for the first time, add 800kg90% ethanol for the second time, filter, combine the extracts, reclaim the ethanol from the extracts and Concentrate to the dilute extract with a relative density of 1.05, pass the dilute extract through HP-20 macroporous adsorption resin, first elute with 30% ethanol until it is colorless, discard the 30% ethanol eluate, and then use 90% ethanol The ethanol was eluted to colorless, and the 90% ethanol eluate was collected, and the ethanol was recovered to obtain an extract. The extract was mixed with silica gel and added to a silica gel column, chloroform-methanol gradient elution, the eluate was collected, detected by thin-layer chromatography, combined, passed through a SephadexLH-20 gel column, and eluted with methanol. Collect the eluate, identify it by thin-layer chromatography, combine it, recover methanol, pass it thr...

Embodiment 2

[0033] Take the stigmaster-8(14), 22-diene-7α-methoxy-3β-alcohol, add dextrin in a ratio of 1:2, mix well, and adopt the existing hard capsule preparation process, namely A drug in the form of a hard capsule containing stigmaster-8(14), 22-diene-7α-methoxy-3β-ol is prepared.

Embodiment 3

[0035] Take the stigmaster-8(14), 22-diene-7α-methoxy-3β-alcohol, add vegetable oil in a ratio of 1:3, mix evenly, use gelatin as capsule shell material, adopt existing soft The capsule preparation process is to prepare the medicine in the form of soft capsule containing stigmaster-8(14), 22-diene-7α-methoxy-3β-ol.

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Abstract

The invention discloses an stigmaster-8(14)22,-diene-7alpha-methoxy-3beta-ol which is extracted from traditional Chinese medicine cucumber roots. The invention also discloses a medical use of the stigmaster-8(14)22,-diene-7alpha-methoxy-3beta-ol on treating diarrhea. The test shows that the stigmaster-8(14)22,-diene-7alpha-methoxy-3beta-ol has a good anti-diarrhea effect on mice diarrhea caused by the senna leaf.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to stigmaster-8(14), 22-diene-7α-methoxy-3β-alcohol extracted from traditional Chinese medicine cucumber root and the medical application of the compound. Background technique [0002] Diarrhea is a group of intestinal infectious diseases mainly caused by pathogenic microorganisms and their products or parasites. It is an ancient and common disease. It is still prevalent all over the world and has become an important global public health today. One of the problems is that the World Health Organization (WHO) estimates that tens of millions of people are sick every day in the world, and diarrhea cases are as high as 3-5 billion cases every year. Adults in developed countries have diarrhea at least 1-2 times a year, and the incidence is higher in developing countries. The incidence of diarrhea in my country ranks first among all infectious diseases, and 836 million p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J9/00A61K31/575A61P1/12
Inventor 李雪松周小江
Owner 湖南本草制药有限责任公司
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