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Amoxicillin and potassium clavulanate tablet for dogs and cats, and its preparation method and application

A technology of potassium amoxicillin-clavulanate and potassium clavulanate, which is applied in the field of potassium amoxicillin-clavulanate tablets, can solve the problems that the content specifications are not suitable for dogs and cats, and can not effectively treat diseases of dogs and cats, and achieve good results. The effect of the therapeutic effect

Inactive Publication Date: 2011-11-16
NANJING SBEED BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the dosage for humans is very different from that for dogs and cats, its content specification is not suitable for dogs and cats, so it often cannot effectively treat the diseases of dogs and cats

Method used

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  • Amoxicillin and potassium clavulanate tablet for dogs and cats, and its preparation method and application
  • Amoxicillin and potassium clavulanate tablet for dogs and cats, and its preparation method and application
  • Amoxicillin and potassium clavulanate tablet for dogs and cats, and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0021] Take respectively 90g of amoxicillin, 40g of potassium clavulanate (carrier is microcrystalline cellulose), 410g of lactose, 350g of microcrystalline cellulose, 62g of cross-linked PVP, 38g of polyvinylpyrrolidone (dehydrated ethanol solution of polyvinylpyrrolidone), Aspartame 5g, beef essence 6g, magnesium stearate 9g, make tablet according to the method described later. The tablet may be a tablet each containing 50 mg of amoxicillin and 12.5 mg of potassium clavulanate.

preparation example 2

[0023] Take 180g of amoxicillin, 80g of potassium clavulanate (carrier is microcrystalline cellulose), 400g of lactose, 260g of microcrystalline cellulose, 40g of cross-linked PVP, 32g of polyvinylpyrrolidone (dehydrated ethanol solution of polyvinylpyrrolidone), Aspartame 5g, beef essence 5g, magnesium stearate 10g, make tablet according to the method described later. The tablet may be a tablet each containing 100 mg of amoxicillin and 25 mg of potassium clavulanate.

preparation example 3

[0025] Take respectively 360g of amoxicillin, 160g of potassium clavulanate (the carrier is microcrystalline cellulose), 280g of lactose, 120g of microcrystalline cellulose, 40g of cross-linked PVP, 28g of polyvinylpyrrolidone (dehydrated ethanol solution of polyvinylpyrrolidone), Aspartame 4g, beef essence 6g, magnesium stearate 12g, make tablet according to the method described later. The tablet may be a tablet each containing 200 mg of amoxicillin and 50 mg of potassium clavulanate.

[0026] Example of preparation method

[0027] Next, the preparation method of amoxicillin-clavulanate potassium (4:1) tablets for dogs and cats will be illustrated by taking the preparation process of the above preparation example 2 as an example.

[0028] First, 180 g of amoxicillin, 400 g of lactose, 260 g of microcrystalline cellulose, and 40 g of cross-linked PVP were mixed in a mixer to obtain mixed powder A. Add an absolute ethanol solution of polyvinylpyrrolidone to the mixed powder A...

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Abstract

The invention relates to an amoxicillin and potassium clavulanate tablet for dogs and cats, and its preparation method and application; the tablet is mainly used for treating and preventing infectious diseases of dogs and cats. According to the invention, the problem of control scope for environmental temperature and humidity in production of the tablet is solved, accessories that guarantee the stability of the tablet are obtained through screening, and a package form that ensures stabilization of the tablet is employed. The tablet is prepared by granulating amoxicillin in advance and then mixing amoxicillin granules with potassium clavulanate for tabletting, which guarantees the quality of tabletting on one hand and reduces the possibility of decomposition of potassium clavulanate on the other hand. The amoxicillin and potassium clavulanate tablet for dogs and cats comprises, by weight, 5 to 45% of amoxicillin, 1 to 20% of potassium clavulanate, 50 to 90% of a diluent, 1 to 10% of a disintegrating agent, 1 to 5% of an adhesive, 0.1 to 3% of a sweetener, 0.2 to 2% of an aromatic and 0.5 to 3% of a lubricant, wherein the carrier for potassium clavulanate is microcrystalline cellulose. The preparation method mainly comprises the steps of pulverizing, granulating, drying, size grading, granule mixing, tabletting and packaging.

Description

technical field [0001] The invention relates to amoxicillin-clavulanate potassium tablets, in particular to amoxicillin-clavulanate potassium tablets for dogs and cats suitable for veterinary clinics and a preparation method and application thereof. Background technique [0002] Amoxicillin and clavulanate potassium tablets are widely used in clinical medicine. They are compound preparations of amoxicillin and clavulanate potassium and belong to β-lactam antibiotics. β-lactam antibiotics are currently the most important veterinary clinical anti-infective drugs. Amoxicillin is a para-hydroxy homologue of ampicillin. Its antibacterial spectrum and antibacterial effect are basically the same as ampicillin. Play its antibacterial effect. With the continuous development of antibiotics and a large number of clinical applications, resulting in bacterial drug resistance, the main mechanism is due to the production of β-lactamase bacteria. Clavulanic acid is one of the most widely ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K31/424A61K9/20A61P11/00A61P13/02A61P1/00A61P17/00A61P31/00
Inventor 高国锋
Owner NANJING SBEED BIOTECH
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