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Compositions and methods for functionalizing or crosslinking ligands on nanoparticle surfaces

A nanoparticle, surface ligand technology, applied in the field of ligand stabilization of nanoparticles, functionalization and/or crosslinking of ligands bound to nanocrystals, and ligands in crosslinking nanoparticle surface coatings, capable of Solve the problem of inappropriate use of hydrophobic nanoparticles

Inactive Publication Date: 2011-11-09
LIFE TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, conventional methods of preparing nanoparticles can produce hydrophobic nanoparticles that are unsuitable for use in aqueous media

Method used

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  • Compositions and methods for functionalizing or crosslinking ligands on nanoparticle surfaces
  • Compositions and methods for functionalizing or crosslinking ligands on nanoparticle surfaces
  • Compositions and methods for functionalizing or crosslinking ligands on nanoparticle surfaces

Examples

Experimental program
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Effect test

example 1

[0240] Functionalization and THPP crosslinking of octylphosphine oxide-coated nanoparticles with 4-aminobenzophenone

[0241] Surface-exchanged trioctylphosphine oxide-coated CdSe nanocrystals prepared according to Example 1 of U.S. Patent No. 6,322,901 were added to a solution of 4-aminobenzophenone in hexane or carbon tetrachloride, and Stir until dispersed. The solution was exposed to sufficient UV radiation at ambient temperature to generate 4-aminobenzophenone free radicals. The resulting solution was concentrated to a few milliliters by evaporation, then the nanocrystals were precipitated and isolated.

[0242] The nanocrystals were dispersed in chloroform and cross-linked using tris(hydroxymethyl)phosphonopropionic acid (THPP) under the conditions described in U.S. Patent No. 7,198,847, which consisted of treatment with 1.2 mL of THPP at room temperature in approximately 100 mL About 1-3 mg of nanocrystalline samples in chloroform were added for 1 hour, then 100 mL of...

example 2

[0244] Functionalization of TOPO / TOP coated nanoparticles with 4-aminobenzophenone:

[0245] AMP-coated TOPO / TOP-coated CdSe / ZnS core / shell nanocrystals prepared according to Examples 1-2 of U.S. Patent No. 6,649,138 were dispersed in 4-aminobenzophenone in chloroform or carbon tetrachloride in the solution. The solution was exposed to sufficient UV radiation at ambient temperature to generate 4-aminobenzophenone free radicals. The resulting solution was concentrated to a few milliliters by evaporation, then the nanocrystals were precipitated and isolated.

example 3

[0247] Functionalization of histidine ligand-coated nanoparticles with 4-aminobenzophenone:

[0248] Histidine-containing molecule-coated CdSe / ZnS core / shell nanocrystals prepared according to Example 1 of US Patent No. 6,955,855 were dispersed in a solution of 4-aminobenzophenone in chloroform. The solution was exposed to sufficient UV radiation at ambient temperature to generate 4-aminobenzophenone free radicals. The resulting solution was concentrated to a few milliliters by evaporation, then the nanocrystals were precipitated and isolated.

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Abstract

This disclosure provides novel ways to modify / functionalize, including crosslink, ligands in the surface coating or molecules in other coatings on a nanoparticle, by using radical addition reactions to add a reactant group onto a ligand / molecule of a nanoparticle. Examples include using a functionalized benzophenone that can be attached or crosslinked to a ligand in the surface coating of a nanocrystal by photochemically-initiated radical addition.

Description

[0001] cross reference [0002] This application claims priority to US Provisional Application Serial No. 61 / 102,666, filed October 3, 2008, which is hereby incorporated by reference in its entirety. technical field [0003] This application relates in part to nanoparticles and methods of manipulating nanoparticles. In some embodiments, the present application provides novel nanoparticles and compositions thereof. In some embodiments, the present application provides methods of modifying nanoparticles with surface ligands and optional additional coatings. In some embodiments, the present application provides methods of modifying nanoparticles with surface coatings and additional coatings. In some embodiments, the present application provides methods of crosslinking ligands in nanoparticle surface coatings. In some embodiments, the present application provides methods of preparing stabilized nanoparticles having cross-linked ligands, wherein the cross-linking is achieved by ...

Claims

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Application Information

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IPC IPC(8): B82B3/00
CPCG01N33/587B82Y15/00G01N33/54353G01N33/588
Inventor E.塔尔斯基W.黄J.古德温W.赵
Owner LIFE TECH CORP
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