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Medicament for treating myocardial ischemia and preparation method thereof

A technology of myocardial ischemia and medicine, which is applied in the direction of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., can solve difficult problems such as cure, achieve simple manufacturing process, reduce production cost, and improve the effect of activity

Inactive Publication Date: 2011-11-09
DEZHI XIAMEN BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Western medicines currently used for the treatment of myocardial ischemia are mainly nitrate compounds, beta receptor blockers and calcium antagonists, etc., but these drugs can only be used to relieve symptoms and are difficult to cure thoroughly; for the treatment of myocardial ischemia Chinese patent medicines mainly include Danshen Tablets, Suxiao Jiuxin Pills, Guanmaining Tablets, Xueshuan Xinmaining Tablets, Guanxin Capsules, Compound Danshen Tablets, Compound Danshen Dripping Pills, Shexiang Baoxin Pills, Di'ao Xinxuekang, Guanmaining, Tongxinluo , Nuodikang (Rhodiola rosea) and Ginkgo biloba preparations, etc.
However, due to the large number of patients with ischemic cardiovascular and cerebrovascular diseases and the various pathogenesis, the existing drugs still cannot meet the clinical needs. Therefore, it is necessary to invent a high-efficiency and low-toxicity drug to meet the needs of clinicians and patients.

Method used

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  • Medicament for treating myocardial ischemia and preparation method thereof
  • Medicament for treating myocardial ischemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] White flower front beard 29kg

[0038] Licorice 1kg

[0039] Add 70% ethanol to Peucedanum radix for reflux extraction (10 times the amount of ethanol, 3 times, 2 hours each time), combine the extracts, recover ethanol under reduced pressure, and dry in vacuum to obtain dry extract 1; moisten the licorice thoroughly, slice , add 10 times the amount of water and decoct 3 times, each time for 2 hours, combine the decoction, let it stand overnight for precipitation, take the supernatant and concentrate it to a thick paste, and dry it in vacuum to obtain dry extract 2; combine dry extract 1 And dry extract 2, it is pulverized into powder and obtains the active ingredient of 3kg medicine of the present invention.

Embodiment 2

[0041] Peucedan beard with white flowers 5kg

[0042] Licorice 25kg

[0043] Add 80% ethanol to Peucedanum radix for reflux extraction (8 times the amount of ethanol, 2 times, 2 hours each time), combine the extracts, recover ethanol under reduced pressure, and dry in vacuum to obtain dry extract 1; moisten the licorice thoroughly, slice , add 8 times the amount of water and decoct 3 times, each time for 2 hours, combine the decoction, let it stand overnight to precipitate, take the supernatant and concentrate it to a thick paste, and dry it in vacuum to obtain dry extract 2; combine dry extract 1 And dry extract 2, it is pulverized into powder and obtains the active ingredient of 3kg medicine of the present invention.

Embodiment 3

[0045] White Flower Peucedanum 25kg

[0046] Licorice 5kg

[0047] Add 95% ethanol to Peucedanum radix for reflux extraction (10 times the amount of ethanol, 3 times, 2 hours each time), combine the extracts, recover the ethanol under reduced pressure, and dry in vacuum to obtain dry extract 1; moisten the licorice thoroughly, slice , add 8 times the amount of water and decoct 3 times, each time for 2 hours, combine the decoction, let it stand overnight to precipitate, take the supernatant and concentrate it to a thick paste, and dry it in vacuum to obtain dry extract 2; combine dry extract 1 , and dry extract 2, it is pulverized into powder, has just prepared the active component of 3kg medicine of the present invention.

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Abstract

The invention discloses a medicament for treating myocardial ischemia and a preparation method thereof, and the medicament comprises an active component with an effective amount for treating myocardial ischemia, and a pharmaceutically-acceptable carrier, wherein the active component is prepared by the following raw materials by weight: 1-30 parts of peucedanum praeruptorum dunn and 1-5 parts of licorice. It is also proved by pharmacological tests that the combination of peucedanum praeruptorum dunn and licorice with the above ratios has comparable effect on treating myocardial ischemia caused by pituitrin and myocardial ischemia due to rat coronary artery ligation with composite salvia dropping pills.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Myocardial ischemia refers to a clinical state in which coronary blood flow decreases, myocardial oxygen supply decreases, and myocardial energy metabolism is abnormal due to various reasons, resulting in the heart not working normally. The Western medicines currently used for the treatment of myocardial ischemia are mainly nitrate compounds, beta receptor blockers and calcium antagonists, etc., but these drugs can only be used to relieve symptoms and are difficult to cure thoroughly; for the treatment of myocardial ischemia Chinese patent medicines mainly include Danshen Tablets, Suxiao Jiuxin Pills, Guanmaining Tablets, Xueshuan Xinmaining Tablets, Guanxin Capsules, Compound Danshen Tablets, Compound Danshen Dripping Pills, S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P9/10
Inventor 冷雪峰邹军
Owner DEZHI XIAMEN BIOLOGICAL TECH
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