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Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof

A technology for gastric mucosal injury and composition, which is applied in the field of traditional Chinese medicine composition for preventing and treating gastric mucosal injury and its preparation field, can solve the problems of easy generation of drug resistance, large side effects, easy recurrence and the like, achieves prevention and treatment of gastric mucosal diseases, protection The effect of gastric mucosa

Active Publication Date: 2011-11-02
SHIJIAZHUANG ZANGNUO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Drugs currently on the market for treating gastric mucosal injury include antacids (sodium bicarbonate, etc.), gastric mucosal protective agents (Livzon Dele, etc.), anti-helicobacter pylori drugs, etc., but these drugs have large side effects and are prone to recurrence , prone to drug resistance

Method used

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  • Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof
  • Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof
  • Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Composition (weight):

[0034] Astragalus 50g, Poria 22g, Dandelion 17g, Evodia 10g, Angelica dahurica 10g, calcined oyster 5g.

[0035] 2. Preparation method:

[0036] 1) Screening, picking, arranging, and processing the various medicines in the above weight ratio;

[0037] 2) Astragalus, Poria cocos, dandelion, and Evodia rutaecarpa were decocted twice, adding 10 times the amount of water each time, and decocted for 2 hours. Concentrate under reduced pressure to (-0.065Mpa, 75°C) to a clear paste with a relative density of 1.30-1.35 (measured at 60°C);

[0038] 3) The concentrated solution is vacuum-dried (-0.085Mpa, 65°C) to obtain a dry extract, which is crushed through a 100-mesh sieve to obtain a fine powder A;

[0039] 4) Angelica dahurica is crushed into fine powder, passed through a 100-mesh sieve; oyster (calcined) is crushed, passed through a 80-mesh sieve, and mixed to obtain fine powder B;

[0040] 5) Mix A and B powders, add 9.1 g of dextrin and 0.44 ...

Embodiment 2

[0041] Embodiment 2: Determination of extraction process parameters

[0042] According to the summary and induction of the literature and materials, combined with the actual production experience, the preparation is formulated to operate as follows:

[0043] 1) Angelica dahurica and oyster (calcined) are powdered and used as medicine;

[0044] 2) Astragalus, Poria, Dandelion, and Evodia are decocted with water, filtered, and the filtrate is concentrated into a clear ointment;

[0045] 3) The above-mentioned Qinggao is dried under reduced pressure, pulverized, mixed, granulated, sized, filled, and packaged.

[0046] In order to make some technical parameters of crushing process and extraction process more specific, the process parameters such as powder yield, solvent addition, extraction time, and extraction times were investigated respectively.

[0047] 1. Inspection of crushing process

[0048] 1.1 Investigation on the crushing process of Angelica dahurica medicinal materi...

Embodiment 3

[0098] Embodiment 3: Safety investigation

[0099] 1. Materials

[0100] 1.1 Experimental drug: The drug prepared according to Example 1, named Huangpu Fuling Capsule or the test substance, was provided by Shijiazhuang Zangnuo Biotechnology Co., Ltd., and the contents were brown granules and powder. The recommended daily dose for adults is 2100mg / 60kg.BW.

[0101] 1.2 Experimental animals: Kunming mice and SD rats were provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences, production license number: SCXK (Sichuan) 2004-16.SPF grade.

[0102] 2. Test method

[0103] 2.1 Rat and mouse acute toxicology test:

[0104] 20 Kunming mice and 20 SD rats were used, half male and half female, the weight of the mice was 18-22g, and the weight of the rats was 180-220g. The large and small mice were randomly divided into two groups, 10 in each group, half male and half male . The test set up a dose group of 15000mg / kg·BW according to the maximum tolerat...

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Abstract

The invention discloses a Chinese medicinal composition for preventing and treating injury of gastric mucosa and a preparation method thereof. The Chinese medicinal composition comprises the active ingredients prepared from the following Chinese medicines in part by weight: 24 to 65 parts of astragalus, 18 to 40 parts of Indian buead, 5 to 26 parts of Mongolian dandelion herb, 3 to 15 parts of medicinal evodia fruit, 3 to 21 parts of angelica dahurica and 0.5 to 9 parts of calcined oyster shell. The invention also provides a preparation containing the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition for preventing and treating the injury of gastric mucosa has the effects of supplementing qi and tonifying spleen, clearing away heat and eliminating dampness and lowering adverse flow of qi and harmonizing stomach under the action of the medicines to achieve the effect of protecting the gastric mucosa. Experiments prove that the Chinese medicinal composition can be used for preventing and treating gastric mucosa diseases.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing and treating gastric mucosal damage and a preparation method thereof. Background technique [0002] Gastric mucosal disease is the most common disease among many stomach diseases. The clinical manifestations are pantothenic acid, belching, nausea, vomiting or chronic mid-upper abdominal pain after meals. In severe cases, there may be melena and hematemesis. With the accelerated pace of social life and huge work pressure, it often leads to irregular eating, non-drinking or overeating. At the same time, people's eating habits, eating preferences, overeating, spicy and alcoholism are all important causes of gastric mucosal damage. According to statistics, the incidence of gastrointestinal diseases in the United States is 10% for men and 5% for women: 5-10% for Japan; 12.3% for Germany. The average incidence of gast...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P1/04A61K35/56A61K35/618
Inventor 王智森高飞
Owner SHIJIAZHUANG ZANGNUO BIOTECH
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