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Blood processing filter and blood filtering method adopting same

A blood treatment and filter technology, applied in blood circulation treatment, blood transfusion equipment, etc., can solve the problems of long sterilization time, deterioration of blood preservation solution, poor vapor permeability, etc.

Active Publication Date: 2011-10-05
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in consideration of the need to sterilize the entire device in order to process blood preparations, when the filter element is filled in the above-mentioned hard container, the vapor permeability is poor and a long sterilization time is required.
In addition, when the autoclave sterilization is performed for a long time, since the deterioration of the blood storage solution is caused, it is necessary to perform complicated procedures such as sterilization after connecting the blood bag, the circuit, etc., after sterilization with the filter. homework

Method used

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  • Blood processing filter and blood filtering method adopting same
  • Blood processing filter and blood filtering method adopting same
  • Blood processing filter and blood filtering method adopting same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] use has figure 2 The FlexRC filter (manufactured by Asahi Kasei Medical Co., Ltd., with an effective filtration membrane area of ​​42.2 cm) at the inlet side port and the outlet side port shown 2 ) to filter the red blood cell preparation (the number of white blood cells: 9.6×10 9 each) 320ml. The height difference between the blood bag and the FlexRC filter (hereinafter referred to as the filter of the first embodiment) was set to 75 cm.

[0073] to be able to obtain image 3 The conduit connected to the filter of the first embodiment is stretched and fixed in the space Sb. figure 2 The values ​​of θa and θb in are 45° respectively.

[0074] The initial line speed is 0.21ml / min / cm 2 , the average linear velocity is 0.18ml / min / cm 2 , the final line speed is 0.15ml / min / cm 2 . The filtration time was 42.1 minutes, and the number of remaining white blood cells in the red blood cell preparation filtered by the filter of the first embodiment was 5.0 (log WBC). Thu...

Embodiment 2

[0076] In addition to will figure 2 The values ​​of θa and θb in are respectively set to 78°, and the same operation as that of Example 1 is carried out. Hereinafter, this FlexRC filter is referred to as the filter of the second embodiment.

[0077] The initial line speed is 0.24ml / min / cm 2 , the average linear velocity is 0.20ml / min / cm 2 , the final line speed is 0.17ml / min / cm 2 . The filtration time was 37.9 minutes, and the number of remaining white blood cells in the red blood cell preparation filtered by the filter of the second embodiment was 4.8 (log WBC). From this, it can be seen that by adopting the inclined port portion of the second embodiment of the present invention, it is possible to easily construct an environment (space) where close contact between the flexible container and the blood processing filter is difficult. A uniform flow can be ensured without obstructing the flow of blood, and effective blood treatment can be performed. As a result, compared w...

Embodiment 3

[0079] use has Figure 5 Inlet side port section shown and Figure 6The FlexRC filter (manufactured by Asahi Kasei Medical Co., Ltd.) at the port on the outlet side shown has an effective membrane area of ​​42.2 cm 2 ) to filter the red blood cell preparation (the number of white blood cells: 9.6×10 9 each) 320ml. The height difference between the blood bag and the FlexRC filter (hereinafter referred to as the third embodiment filter) was set to 75 cm.

[0080] to be able to obtain Figure 6 The conduit connected to the filter of the third embodiment is stretched and fixed in the space Sb. Use braces set to Figure 5 θc in Figure 6 The values ​​of θd in are 30°, respectively.

[0081] The initial line speed is 0.19ml / min / cm 2 , the average linear velocity is 0.17ml / min / cm 2 , the final line speed is 0.14ml / min / cm 2 . The filtration time was 44.6 minutes, and the number of remaining white blood cells in the red blood cell preparation filtered by the filter of the th...

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Abstract

The invention provides a blood processing filter and a blood filtering method adopting the same. The blood processing filter includes the flexible container having an inlet and an outlet for blood and the sheet-like blood processing filter material which is arranged to separate the inside of the container into the inlet side and the outlet side, wherein the flexible container includes a container body for accommodating the blood processing filter material and an inlet side port which is fixed to the container body to form the inlet or outlet, the inlet side port has an inlet side main tube section connected to a conduit that transports the blood and a fixed part which communicates the inlet side main tube section into the container body and fixes the inlet side main tube section to the outer surface of the container body, and the axis of main tube section inclines relative to the tangent of the outer surface of the container body.

Description

technical field [0001] The present invention relates to a blood treatment filter for removing undesirable components such as aggregates and white blood cells from blood. In particular, it relates to a precise and disposable blood that is used for the purpose of removing fine aggregates and white blood cells that cause side effects from whole blood preparations for blood transfusion, red blood cell preparations, platelet preparations, plasma preparations, etc. The processing filter is particularly related to a flexible filter using a resin material or the like as a material of a container. Background technique [0002] Whole blood collected from blood donors is usually separated into blood component preparations such as red blood cell preparations, platelet preparations, and plasma preparations, and stored before being transfused. In addition, since the fine aggregates and white blood cells contained in these blood preparations cause various side effects of blood transfusion...

Claims

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Application Information

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IPC IPC(8): A61M1/02A61M1/36
Inventor 三浦司和大石辉彦
Owner ASAHI KASEI MEDICAL CO LTD
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