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Oral liquid preparation for curing wind-heat type cold and preparation method thereof

A liquid preparation, the technology of Fengreganmao, which is applied in the field of medicine, can solve problems such as poor taste, and achieve the effects of improving compliance, improving bitter taste, and increasing water solubility

Inactive Publication Date: 2011-09-21
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main contribution of the present invention is to improve the original taste correction process, and solve the problem of poor taste of the existing preparations by adopting cyclodextrin inclusion technology and screening the amount of cyclodextrin

Method used

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  • Oral liquid preparation for curing wind-heat type cold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Preparation of Chaiyin Oral Liquid

[0045] 1) Extraction and concentration process: (refer to the specification or Chinese invention patent ZL03100188.2, a traditional Chinese medicine composition for treating anemopyretic cold and its preparation method.)

[0046] Crush 0.5kg of bitter almonds, mix with 1.0kg of bupleurum, 0.75kg of honeysuckle, 0.5kg of nepeta, 0.75kg of artemisia annua, 0.75kg of forsythia, 0.75kg of mint, 0.75kg of houttuynia, etc., add 10 times the amount of water Soak for 1 hour, heat and distill for 2.5 hours, collect 4500ml of distilled liquid; release the leaching medicinal liquid after distillation, decoct the dregs with 0.6kg of Scutellaria baicalensis, 0.5kg of Platycodon grandiflora, and 0.5kg of Pueraria radiata three times, and add 8 times the amount of water for the first time , decoct for 1.5 hours, add 6 times the amount of water for the second time, decoct for 1.0 hour, add 6 times the amount of water for the third time, an...

Embodiment 2

[0049] Example 2 Preparation of Chaiyin Oral Liquid

[0050] 1) Extraction and concentration process:

[0051] See embodiment 1;

[0052] 2) Preparation process:

[0053] Filter the water extract, add purified water to the filtrate to 7500ml, adjust the pH to 7.2, add a total of 1.5% α-cyclodextrin, control the inclusion temperature at 20-30°C, stir for 60 minutes, filter, and the filtrate Add 40% sucrose and 0.2% sodium benzoate in the total amount of preparation, stir to dissolve, add purified water to 7500ml, filter until the clarity is qualified, and then fill, the specification is 20ml / cartridge, sterilized by circulating steam at 100°C for 60 minutes, and packaged. .

Embodiment 3

[0054] Example 3 Preparation of Chaiyin Oral Liquid

[0055] 1) Extraction and concentration process:

[0056] See embodiment 1;

[0057] 2) Preparation process:

[0058] Filter the water extract, add purified water to the filtrate to 7500ml, adjust the pH to 7.2, add 1.5% gamma-cyclodextrin in total, control the clathrate temperature at 20-30°C, stir clathrate for 60 minutes, filter, and filtrate Add 40% sucrose and 0.2% sodium benzoate in the total amount of preparation, stir and dissolve, add purified water to 7500ml, filter until the clarity is qualified, and then fill it. have to.

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Abstract

The invention discloses an oral liquid preparation (a Chaiyin oral liquid) for curing a wind-heat cold and a preparation method thereof. To overcome the defects of traditional flavoring technologies of the Chaiyin oral liquid, a cyclodextrin complexation technique is employed, and other flavorings are used to carry out a combined taste modification. So the oral liquid preparation with a proper taste is developed, thereby industrialization of traditional Chinese medicine oral liquid preparation production with the applied cyclodextrin complexation technique is realized, the taste of the preparation is improved, the medication compliance of patients is increased, simultaneously water solubility of effective components with low polarity is improved through clathrate formation, and the quality and the stability of the preparation are improved.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an oral liquid preparation for treating anemopyretic cold and a preparation method thereof, in particular to a chaiyin oral liquid and a preparation method thereof. Background technique [0002] Chaiyin Oral Liquid is a three-category Chinese patent medicine for the treatment of wind-heat and cold. In the prescription, Bupleurum is used to lighten and disperse the powder, and to dissipate the surface and expel heat as the monarch drug; honeysuckle, scutellaria, forsythia, kudzu root, artemisia annua and Nepeta, the above six flavors can clear away heat Relieves the exterior, clears the lungs and relieves heat, clears the muscles and relieves fever, both are ministerial medicines; peppermint, houttuynia cordata and bitter almonds, relieve throat and quench thirst, clear lungs and expel heat, resolve phlegm and relieve cough, as adjuvant medicine; platycodon grandiflorum is specially used in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/00A61K47/48A61P11/04A61P11/14A61P25/04A61P29/00
Inventor 赵志全张则平
Owner LUNAN HOPE PHARM CO LTD
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