Muramidase hydrolase external sterile cream for treating skin ulcer and preparation method thereof

Abstract

The invention discloses a muramidase hydrolase external sterile cream for treating skin ulcer and a preparation method thereof. The muramidase hydrolase external sterile cream is prepared from the following raw materials of: muramidase hydrolase, Span, poloxamer, Tween, sorbierite, sodium dihydrogen phosphate, ethylparaben, liquid paraffin, glycerin monostearate, cetyl alcohol, stearyl alcohol, albolene and sterile water. The invention also provides a preparation method for the muramidase hydrolase external sterile cream. The preparation method comprises the following steps of: dissolving; performing high temperature sterilization; filtering and removing bacteria by using a filter membrane; homogenizing at a low speed; homogenizing at a high speed; stirring; reducing temperature; and performing sterile filling. The muramidase hydrolase external sterile cream is used for treating the skin ulcer including bedsore, burn ulcer, calf ulcer, post-zoster ulcer, diabetic ulcer and postoperative ulcer in a transdermal administration form.

Description

technical field [0001] The invention relates to a sterile cream for external use of lysozyme hydrochloride for treating skin ulcers (bedsores, scald ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, and postoperative ulcers) and a preparation method thereof, which belong to medical technology field. Background technique [0002] Skin ulcers, including decubitus ulcers, burn ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, and postoperative ulcers, refer to localized defects formed by local skin or adhesive necrosis, disintegration, and shedding. [0003] In my country, skin ulcers and decubitus diseases are common and frequently-occurring diseases. The etiology of skin ulcers and decubitus ulcers is soft tissue necrosis caused by neurotrophic disorders, blood circulation disorders, local tissue continuous ischemia, and malnutrition. If not treated in time, other organ complications may be induced. According to relevant literature reports, the incidence r...

AI Technical Summary

Problems solved by technology

If the raw materials, auxiliary materials and production conditions used in the preparation are not sterilized or the sterilization method is improper, it is easy to cause secondary infection in clinical practice, making it more difficult to heal the wound surface, resulting in unsatisfactory treatment effect or greater damage to the ulcer surface. harm

In addition, lysozyme hydrochloride sterile topical drugs specially used for the treatment of skin ulcers (bedsores, scald ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, postoperative ulcers), especially lysozyme hydrochloride sterile cream Preparations have not been reported yet

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